I've been printing with the MF1's for a while now, pretty happy with it. Printing Nylon, ABS, HIPS and PLA. Pla prints 100%, been through three spools and not a clog. Switched over to ABS for some quadcopter building and got a clog 70% the second spool, pretty easy to clean it out. The extruder tips are pretty "flat" so it doesn't catch on pieces as much as my old MK7's used to.
Pros
-no insulation needed
-fixed extruder "neck" so no need to level print heads
-internal thermocouple (figure temp is more accurate)
Cons
-PEEK based "neck", handles ABS fine, but worries me printing above 240C for Nylon. I printed some stainless steel replacements through shapeways ($20 each, worth it)
Anyway, I still recommend them. As far as fitment on 2x, i'd suggest emailing Mbot and asking. I have a Replicator1 clone (CTC dual extruder) and it was a drop in replacement. Build quality is excellent.