Crack Superpro Designer V9
Meri Thilmony
A bioprocess is a specific process that uses complete living cells or their components like bacteria, enzymes, and chloroplasts to obtain desired products. Bio industry is important in the utilization of reproducible resources, developments of environmentally friendly production processes, and a sustainable economy. Bioprocess optimization and automatic control are needed to make the bioprocesses more efficient and economic. The conventional optimization methods cost much labor, time, and money. The research and modern bio industries utilizes modelling and computer simulation method as it is much efficient and economic. In this paper, a bioprocess model for Polyhydroxybutyrate (PHB) biosynthesis from two different sources such as glucose and sucrose is simulated and the optimum parameters for upstream and downstream processes are determined using SuperPro designer software. The material balance and economic evaluation of the batch processes were also carried out. The yield of PHB using sucrose as carbon source is higher (25.07%) as it contains more carbon than glucose
Users of SuperPro Designer lived (and survived) several major revisions of the software without the availability of the "Undo" action button. Starting with this release (v10) the Undo / Redo option is now available; it is part of the Edit (main menu) and also it can be activated with a pair of buttons on the main toolbar (see below):
SuperPro's implementation of "Undo" is slightly different than most programs (e.g. MS-Word) but much more powerful. In a typical program (such as MS-Word), the application will record every action (transformation) that a user applies to his/her open document (for example, add or delete a character) and after it is executed, it will offer to "undo" the most recent change or a continuous sequence of past changes. In SuperPro, since the deletion of a unit procedure has far-reaching implications (e.g. the equipment associated with it is deleted; if other procedure(s) used the same equipment, a new one is created for them; all contained operations are deleted; if any other operation used one of the deleted operations as reference for scheduling, their scheduling is reset, etc. etc.) it is virtually impossible to re-apply all those changes. So, instead of SuperPro 'remembering' the transformations applied by the user after some action is executed (e.g. deleting a unit procedure), it simply records the state of the process file right BEFORE the action is issued. SuperPro will keep recording further states of the simulation file as other changes are applied. That is why if you click on the "Undo" button, you will see a listing like this:
If you select an entry in the Undo list (e.g. "Deleted Wash-2"), essentially you request the program to restore your simulation to the state just before you deleted the stream "Wash-2". Therefore, you don't have to select multiple undo-commands to go back to the state of your simulation in the past.
An easier way to understand this new feature of SuperPro Designer is to pretend that the application takes snapshots of the state of your file and keeps a historical archive of them. It tags each snapshot by the name of the action that was about to be executed right before the snapshot was taken. Once several such snapshots are taken, if you change your mind about the direction your simulation decisions are going, you can visit this list of stored snapshots and choose to return the state of your simulation to match how it was just before the name of the action mentioned in the list of "Undo" entries. That's it. Note that SuperPro will not keep the snapshots of your file for everychange applied to your file. For example, moving an icon is not deemed an important enough action to justify a new snapshot taken before the move. Since every snapshot takes space on your storage device, we have choices that limit this amount; you can specify (choose):
a) the events that are deemed "significant" enough to justify a new record taken, and
b) the number of such records (archives) kept.
The user can modify both of the above options by visiting the File / Application Settings ... dialog (from the main menu) and visit the last tab (Undo/Restore).
If you don't want SuperPro Designer to keep a record after (for instance) modifying the stream elbows, then locate the event in the "Create a Historical Record Before..." list and uncheck it (see green highlight above). If you don't want SuperPro Designer to track any events at all (effectively disable the "Undo"/"Restore" feature), then uncheck the top-right button ("Enable Undo/Restore"). Finally, the "Historical States Recorded" number dictates the depth of history kept by SuperPro Designer in its archives. You can set this value at any number up to 40.
In previous releases, once a user included a given unit procedure in his/her process model and added a sequence of operations in it as well as a set of streams moving material in and out of the host equipment, the only way to replace the procedure with another type of procedure (e.g. replace a "Seed Fermentation" procedure with a regular "Fermentation" procedure), was to delete the seed fermentation procedure (and all the operations in it) first. When this was done, all streams attached to the deleted procedure and all operations within that procedure were deleted as well. This also resulted in deletion of all dependencies in other operations within the model that were based on the durations/timing of the deleted operations. For example, if a downstream centrifugation operation was set to start as soon as the fermentation operation ended, this dependency link would have to be deleted once the old seed fermentation procedure (and therefore the contained operations) were deleted.
Starting with this version, there is a new option under the right-click (context) menu of most unit procedures: "Switch Procedure". This entry will present as sub-options, several other procedure types in the same 'family' of unit procedures as the one we are about to replace, that can be used in place of the current procedure (see below):
Currently the application recognizes the following "families" of procedures:
The members of each unit procedure family are essentially the members of the corresponding submenu on the main menu's Unit Procedure entry (where one would normally choose the type of a unit procedure before it is inserted in the process model).
Also, the new equipment host carries over as many features from the previous equipment host as possible. For example, in the above example, the "Fermentor" equipment created to replace the "Seed Fermentor" will have the same height, diameter, design pressure, heat capacity, etc. as the one it replaced. The user of course, can visit the Equipment Data... dialog and modify as necessary.
Please note that in order to facilitate the transition from one member of unit procedure family to another, we have re-designed the icons (size) and port availability (for inputs and/or outputs). For example, all bulk storage procedures in tanks (Blending, Vertical-on-Legs, Horizontal, etc.) and disposable bags now have 7 inputs and 7 outputs. This will make switching from one to the other quite easy. Storage to smaller containers (such as totes, drums, etc.) all have 5 inputs and 5 outputs, once again, making it easy to switch later in the process development, from one to another.
SuperPro Designer has been calculating and reporting emissions since its original release. However, the calculations involved were based on formal vapor-liquid equilibrium calculations between the liquid and the vapor phase in the vessel where the emissions are assumed to originate. SuperPro Designer allows users to choose from a variety of models when calculating the V/L equilibrium percentages of each component ranging in simplicity from ideal mixture (Raoul's Law) to one of several non-ideal modeling for the liquid and/or gaseous phases (Activity coefficient based models, to fugacity based models to equation of state based models). However, so far, SuperPro Designer didn't give the users the option to estimate and report emissions based strictly on the EPA-MACT guidelines as published by the EPA and accepted for reporting emissions from running processes. Starting with this release, we have added this option. A new report can be generated (see Reports / EPA-MACT Emissions under main menu). This report will calculate emissions for VOCs based on one of the following EPA-recommended models when applicable:
Users have the option to include controlled emissions (if needed) where the condenser on the emissions line can have a user-specified setting (top-right table above). There are several models that can be used to report "Depressurization Emissions" (Option 1, 2 or 3) and for Heat Emissions (Option 1 and 2) - all explained in the manual or the online help facility. The report can also include cumulative HAP and/or VOC values based on the classification of each component emitted (see below):
Finally, the emission amounts are typically NOT subtracted from the vessel contents (unlike what seasoned users of SuperPro Designer would expect). That is customary when reporting EPA emissions. Furthermore, the application will carry out the calculations without actually changing the M&E balance results showing on the process flowsheet. That makes it difficult for users to double-check the results and visualize the equipment contents that yield the reported emissions. That is why the report presents the option to include in the report the contents of the vessel as used to generate the emissions (since those contents cannot be found anywhere in the current model description). Also, if requested, you can have the emission amounts be removed from the contents of the vessel, before the next operation is simulated (see option at bottom right above).
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