Why does selection feel so weak relative to mutation in affinity maturation?

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Erick Matsen

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Aug 19, 2025, 3:27:16 PMAug 19
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Hello everyone--

Why does selection feel so weak relative to mutation in affinity maturation? Here is a new blog post giving three perspectives, including our new transformer-based model of natural selection on antibodies: https://matsen.group/general/2025/08/17/mut-sel-in-bcrs.html .


Hope you are enjoying your summer!


Erick

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