Cenforce | Generic Sildenafil Citrate Starting from $0.25 By Drugsdropship24

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james stewart

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Jul 16, 2014, 8:47:38 AM7/16/14

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What is Cenforce?

Cenforce consist of sildenafil citrate. It is prescribed for the treatment of persistent erectile dysfunction (ED) in men. ED can be defined as inability to achieve and to maintain normal penis erection in the presence of sexual stimulation. Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) enzyme.

How does Cenforce works?

Physiology of penis erection defends upon the concentration of cGMP in presence of sexual stimulation. Cenforce being a cGMP specific PDE5 inhibitor promotes the activity of local nitric oxide by specifically inhibiting PDE5 enzyme (responsible for biodegradation of cGMP) in corpus cavernosum. Increase level of nitric acid and subsequently cGMP result in smooth muscle dilatation and increased influx of blood to the corpus cavernosum.

Cenforce will only exhibit its effect in presence of sexual stimuli.

What are the active ingredients of Cenforce?

Each film coated tablet of Cenforce consists of:

Sildenafil 100 mg

Excipients QS

Coloring agents

Contraindications associated with Cenforce

It is contraindicated in patients with known history of allergic hypersensitivity to Sildenafil or any of the other ingredients present in Cenforce.
Use of sildenafil and nitroglycerine or nitrate drugs is highly contraindicated. Sildenafil promotes effect of vasodilator nitric oxide. So coadministration of sildenafil and nitrate like drugs causes amplified hypotension effect.
Cenforce is not recommended in individuals < 18 years and in women
In patients with severe hepatic and renal dysfunctioning (CLcr <30 mL/min) use of Cenforce is contraindicated.
Sildenafil is absolutely contraindicated in patient with history (past 6 months) of ischemic heart disease, myocardial infarction, in patients with permanent pacemaker, arrhythmia, heart stroke or optic neuropathy.

What are the warnings/precautions?

It is recommended to consult physician prior to administration of Cenforce in case of any underlying health condition.
Dose modification is required in concurrent use of Potent CYP3A4 inhibitors (ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone) and Cenforce. Since CYP3A4 inhibitors are potentially increase the plasma concentration of sildenafil.
Significant alcohol consumption with this medication can cause symptoms of orthostatic hypotension and syncope like light-headedness, fainting, weakness, breathlessness, vision and blurring.
Sexual activity in patients with significant cardiac abnormalities is associated with potential cardiac risk. So in these patients use of sildenafil should be carried out under doctor’s supervision.
Caution should be exercised in concomitant use of antihypertensive (alpha blockers) and Cenforce may result in additional drop in blood pressure. It may lead to symptomatic hypotension.
Patients with penis deformation or suffering from conditions like sickle cell anaemia, multiple myeloma should be cautious while using sildenafil.
Caution is advised while using Sildenafil in patients with bleeding disorders like peptic ulcer
Risk benefit ration should be assessed while using Sildenafil in patients with untreated diabetic retinopathy.

What are the expected side-effects?

Painful and prolonged erection
Headache, dizziness
Flushing
Back and limbic pain
Nasal congestion, rhinitis
Visual deformity or blurred vision
Sudden decrease in hearing ability, ringing sound
Body rashes
Abdominal discomfort e.g., diarrhoea and gastric bleeding, nausea and vomiting

Listed above are not all the side-effects related to Sildenafil. For further information on side-effects please go through the product insert. Consult your physician immediately if any of the above side effects is experienced while using this medication.

What are the possible drug interactions?

Potent CYP3A4 inhibitors and CYP3A4 inducer
Concurrent use of Cenforce with nitrates like isosorbide and monosorbide nitrate, nitroglycerine
Antihypertensive agents
Alcohol

What should be done if dose is missed?

If you missed a dose of Cenforce dose, and you remember it the same day take it as soon as you remember. But if you don’t remember until the next day, then never try to compensate a missed dose. Skip a missed dose and take the drug as it was schedule by your doctor.

What should be done in case of overdosing?

Symptoms can vary from moderate to severe gastrointestinal irritation to low blood pressure, tremor and dizziness. In case of overdosing immediately contact doctor.

What is the Dosage regimen, and how medicine should be taken?

Cenforce is intended for only oral use.
This medicine is recommended once daily about 30 minutes before initiation of sexual activity.
It should we swallowed with water.
It can be taken with or without food.
Dose adjustment by physician is required in specific patients’ population.

What are the storage instructions?

* Sildenafil should be stored in cool and dry place, below 20^o C temperature.

* Do not expose the medication to extreme heat or freezing temperature.

* Keep out of the reach of children and pets.

* The medicine should be checked properly for the expiry date before applying it.