once you tighten the set screw (while the handle is lose) when you go to relock the handle it will be harder. If you loosen the screw the lever will be loser.
This is just a hunch. Everything that Jetguy said may also be in play.
I know when I got my 2X, I had to adjust the set screw a few times.
I mostly print with my right extruder. I had about 300 hours on the stock extruder with maybe 4 air prints. After upgrading to the 3-in-1 (40 hours so far) I've probably had 10-15 jams. I've also played with the adjustment screw on there and still have not got it 100% dialed in.
Another thing you can look at is the filament after you have unloaded it. You want to see some decent teeth marks from the gear. If you're just seeing small indents, then you probably need it tighter. If they are major indents or the stepper clicks/skips steps w/o you trying to stop the filament, then you have it set too tight.