I say this with huge respect, I think that's not a great answer.
Part of the reason to buy a Fusion F306 is the care and attention that goes into the tuning and custom config of each and every one of those. I got kind of lucky and sat next to the prototype that led to the Fusion F306 as we know it today and I have to tell you we shared ideas and that's basically a combination of some ideas I had and ideas he had already put into the design. So again, huge props, it's a good design but what makes it is the attention to detail and each one is built by hand, tuned for many hours before you ever touch it. Given that it uses braided line instead of belts, there is a reason each one is tuned and that is to fine tune steps per mm per axis.
That is put into the custom firmware on the controller.
So yes, you could totally buy one, rip out the controller and swap in a mightyboard- load the Sailfish Core XY firmware and have you a printer. You also paid for tuning that you literally threw away swapping controllers.
You'll also have to change from thermistor to thermocouple on the hotend (but that's not the biggest deal really). Another thing is, you probably want to user aftermarket stepper drivers rather than stock botsteps or you'll need to somehow cut the Vref pin on the botsteps and use a potentiometer circuit to create a voltage divider to increase the current range to drive those bigger motors.
Again, it could be done 100%
But if you are going to do all that- you might as well build a Core XY from the many plans that have been posted from scratch.
Again, buy the Fusion F306 because it's a highly tuned piece of hardware and firmware.
Or
Build from scratch.
I'm just saying, say a mightyboard is now anywhere from $138 for like a cheap knockoff, to $180 for a FlashForge. You still need to get minimally a keypad/sd card slot board and the big ribbon cable is the same 26 pins as used in the older Raspberry Pi (since it is 3.14.15 Pi day) So realistically, if you are just buying parts, all said and done, you probably might have $250 for a mightyboard swap for all cables, LCD, button/SD card board, mightyboard, and either some mods or replacement drivers. And, we cannot forget a type K thermocouple.