Thanks again for such a useful tool.
I have a question regarding the values of psi in an lsv. Thanks to the article you wrote, I understand that the sum of all psi in a LSV must be equal to 1. In general, psi calculation is : #includingreads / (#includingreads + #excludingreads), if I remember well.
So how is it possible that, for example, in a source based LSV such as s|1e1.1o1|1e2.1o1 , that the first junction (which is basically the reference exon being linked to the next exon, without excluding any exon) has a value different from 1 ? Because in this case, the ratio used to calculate psi value, should be for example : 4/4.
Does MAJIQ calculate the psi value of this junction by doing : 1 - (sum(all other junctions in the LSV)) ?
The answer is maybe is the article but I am struggling a bit with the mathmatical formulas. :/
Any help would be highly appreciated !
Have a nice day,