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Cross docking is a logistics strategy when the carrier immediately unloads the cargo from an incoming container and then loads it directly to an outbound carrier, also known as from dock to dock. Life express keeps supply chains moving in a productive, effective manner.
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Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence. Progressive telomere shortening appears to trigger senescence in normal human fibroblasts and retinal pigment epithelial cells, as ectopic expression of the telomerase catalytic subunit, hTERT, immortalizes these cell types directly. Telomerase expression alone is insufficient to enable certain other cell types to evade senescence, however. Such cells, including keratinocytes and mammary epithelial cells, appear to require loss of the pRB/p16(INK4a) cell cycle control mechanism in addition to hTERT expression to achieve immortality. To investigate the relationships among telomerase activity, cell cycle control, senescence, and differentiation, we expressed hTERT in two epithelial cell types, keratinocytes and mesothelial cells, and determined the effect on proliferation potential and on the function of cell-type-specific growth control and differentiation systems. Ectopic hTERT expression immortalized normal mesothelial cells and a premalignant, p16(INK4a)-negative keratinocyte line. In contrast, when four keratinocyte strains cultured from normal tissue were transduced to express hTERT, they were incompletely rescued from senescence. After reaching the population doubling limit of their parent cell strains, hTERT(+) keratinocytes entered a slow growth phase of indefinite length, from which rare, rapidly dividing immortal cells emerged. These immortal cell lines frequently had sustained deletions of the CDK2NA/INK4A locus or otherwise were deficient in p16(INK4a) expression. They nevertheless typically retained other keratinocyte growth controls and differentiated normally in culture and in xenografts. Thus, keratinocyte replicative potential is limited by a p16(INK4a)-dependent mechanism, the activation of which can occur independent of telomere length. Abrogation of this mechanism together with telomerase expression immortalizes keratinocytes without affecting other major growth control or differentiation systems.
Americans are talking to family and friends about race and racial equality: 69%, including majorities across racial and ethnic groups, say they have done so in the last month. And 37% of those who use social networking sites say they have posted or shared content related to race or racial equality on these sites during this period. Smaller shares say they have contributed money to a group or organization that focuses on race or racial equality (9%), contacted a public official to express their opinion on these issues (7%), or attended a rally or protest focused on these issues (6%) in the last month. About one-in-ten among black (10%), Hispanic (9%) and Asian (10%) adults say they have attended a protest, compared with 5% of white adults.
At the same time, large shares of Hispanic (77%), Asian (75%) and white (60%) adults also say they at least somewhat support the Black Lives Matter movement. Still, only about four-in-ten or less of each of these groups express strong support.
Similar partisan gaps are present when looking only among the white population. White Democrats are 55 percentage points more likely than white Republicans to express some level of support for Black Lives Matter (92% vs. 37%). The gap is just as wide when it comes to the shares who are especially supportive: 62% of white Democrats offer strong support, compared with just 7% of white Republicans.
Some 37% of adults who use social networking sites say they have posted or shared content on those sites related to race or racial equality in the last month. Smaller shares of all U.S. adults say they have contributed money to an organization that focuses on these issues (9%), contacted a public official to express their opinion on race or racial equality (7%), or attended a protest or rally that focused on these issues (6%) in the last month. The shares who say they have ever done each of these range from 15% who say they have attended a rally or protest that focused on race or racial equality to 46% who say they have posted or shared content about these topics on social networking sites (among those who use these sites).
The survey also finds wide partisan gaps in these measures of activism, with Democrats and those who lean Democratic more likely than Republicans and Republican leaners to say they have done each of these activities in the last month. For example, one-in-ten Democrats say they have contacted a public official to express their opinion on issues of race or racial equality or attended a protest or rally focused on these issues (10% each) in the last month; just 3% of Republicans say they have contacted a public official and 2% say they have attended a protest focused on race or racial equality. And while 16% of Democrats say they have contributed money to a group or organization that focuses on race or racial equality in the last month, just 3% of Republicans say they have done this.
Express is a modern, multichannel apparel and accessories brand, as well as a go-to style destination. From wardrobe essentials to the latest trends, we design clothes for real-life versatility. Express is a brand with a purpose, powered by a styling community.
We Create Confidence. We Inspire Self-Expression.
In 1883, Georges Nagelmackers created a legendary train: the Orient-Express. On the journey from Paris to Constantinople, High-Life magazine was distributed to travelers, and focused on the cities of the world, artistic life and craftsmanship.
Cultural backgrounds, family values, and many other factors can influence how we express emotions. Typically, we learn to express our emotions in two primary ways: either directly expressing them to someone else (e.g., in a personal confrontation), or hiding the feelings and keeping them to ourselves. Learning ways to express our emotions that are aligned with our cultural values, while still attending to our need and feelings, can be helpful both for ourselves and in our relationship with others.
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This article will look at the ways we can best express our gratitude, the benefits of expressing the gratitude we feel towards others, and how you can practice the act of gratitude whilst learning to appreciate the positive emotions that accompany it.
There is a wealth of evidence reflecting on the benefits we derive from expressing gratitude and appreciation; such expressions evoke an array of psychological, social, and physical benefits that promote our psychological, social and physiological health (Wood, Froh, & Geraghty, 2010).
The expression of gratitude is a self-promoting exercise, grateful people are found to be more likely to respond with gratitude to a wider range of scenarios and recognize the beneficence on the part of others.
The expression of gratitude plays a pivotal role in building and maintaining social relationships. Research into the role of gratitude in real, ongoing, relationships looked at naturally occurring gratitude in college sororities during a week of anonymous gift-giving from existing members to new members (Little Sisters).
Additionally, expressions of gratitude also increase prosocial behavior (behaviors that are intended to benefit others) by enabling individuals to feel social worth and support while simultaneously reducing their feelings of uncertainty about whether they can help effectively (Grant & Gino, 2010).
Gratitude expression is uniquely important to psychological wellbeing and linked to enhanced positive emotions, resilience, better coping skills, and an improved ability to manage stress, and an increase in happiness (Sansone & Sansone, 2010. Wood, Joseph, & Maltby, 2009).
Gratitude expression correlates positively with self-reported physical health and, through the mediation of psychological health, increases healthy activities and willingness to seek help for health concerns (Hill, Allemand, & Roberts, 2013).
These detailed, science-based exercises will equip you or your clients with tools to build daily gratitude habits, express more appreciation toward others, and experience more positive emotions in everyday life.
It is often the simplest of gestures that speak volumes in showing your gratitude. We all have people in our lives who inspire us and generally just make life better by being in it; here we will look at ways to express gratitude to those who should really hear it.
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