CALA 2021 Friday Happy Hour Series

[Ke Yuan]

2021 CALA Happy Friday Seminar
March 26th, 2021
https://arizona.zoom.us/j/97032505774 (Password: 654321)

Time: EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

Bingqiang Wen, PhD
Research Fellow at Vladimir V. Kalinichenko lab
Cincinnati Children's Hospital Medical Center

Title: The Use of Mouse-Mouse and Mouse-Rat Chimeras to Generate Lung Tissue from Embryonic Stem Cells

Abstract: Dr. Wen obtained his Ph.D. at China Agriculture University. He is a research fellow at Cincinnati Children's Hospital Medical Center. His research interests include lung regeneration, lung progenitor cells. His current project focus on optimization of methods for interspecies organogenesis to generates functional respiratory organ by blastocyst complementation. He has publications in some journals including AJRCCM, theriogenology et al. His research study has been published in AJRCCM (PMID: 32877203).

See you soon.

CALA

[Ke Yuan]

See you tomorrow.

CALA

[Ke Yuan]

希望大家积极参加CALA Happy Friday Seminars。不但可以增加学术交流，启发创新。对于年轻人还可以大幅提高你们的演说和科研水平。

4/9 10:30am EST，北京时间晚上10点半。

Title:Building a Modeling System to Study Whole Lung Vasculature

Presenter:

Dr. Yifan Yuan, Postdoctoral Fellow, Yale University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Dr. Yuan obtained his PhD at Ottawa Hospital Research Institute from Dr. Duncan Stewart's group focusing on vascular biology and regeneration. He subsequently went to join Dr. Laura Niklason's group at Yale to learn whole lung tissue engineering. His research interests involve vascular biology, tissue engineering, and disease modeling. His work has been published in numerous biomedical journals including Biomaterials, and Acta Biomaterialia.

[Ke Yuan]

希望大家积极参加CALA Happy Friday Seminars。不但可以增加学术交流，启发创新。对于年轻人还可以大幅提高你们的演说和科研水平

4/9 10:30am EST，北京时间晚上10点半。

Title:Building a Modeling System to Study Whole Lung Vasculature

Presenter:

Dr. Yifan Yuan, Postdoctoral Fellow, Yale University 

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Dr. Yuan obtained his PhD at Ottawa Hospital Research Institute from Dr. Duncan Stewart's group focusing on vascular biology and regeneration. He subsequently went to join Dr. Laura Niklason's group at Yale to learn whole lung tissue engineering. His research interests involve vascular biology, tissue engineering, and disease modeling. His work has been published in numerous biomedical journals including Biomaterials, and Acta Biomaterialia.

[Ke Yuan]

Please see the enclosed flyer for this Friday talk.

See you soon.

[Ke Yuan]

Dear all，

本周seminar，欢迎大家积极参与。Judy is a CF authority，在CF foundation很有影响力。她过去是pulmonary chief at Duke。

CALA Happy Hour 在线讲座系列: Dr. Judith A. Voynow

美中呼吸CALA 

Title:

Neutrophil Elastase and Macrophage Function in Cystic Fibrosis

Presenter:

Dr. Judith A. Voynow, Edwin L. Kendig Jr. Professor, Virginia Commonwealth University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

 

Abstract:

Neutrophil elastase (NE) is a major inflammatory mediator in the airways of patients with cystic fibrosis (CF). NE is present in the bronchoalveolar lavage of infants with CF and is associated with early onset of bronchiectasis, airway damage that is the hallmark of CF lung disease. NE is present in high concentrations of older patients with CF and is associated with worse lung function. Dr. Voynow has been studying the mechanisms of NE remodeling in airway biology to and initially focused on its role to upregulate mucin gene upregulation and goblet cell metaplasia. More recently, she has been investigating the role of NE to impair CF airway innate immunity. In this presentation, she will discuss how NE impairs macrophage function in the CF airway and she will also present data on novel drug therapies that are being developed to inhibit NE.

[Ke Yuan]

本周seminar，(周五）早上10:30am EST, 欢迎大家积极参与。Judy is a CF authority，在CF foundation很有影响力。她过去是pulmonary chief at Duke

Title:

Neutrophil Elastase and Macrophage Function in Cystic Fibrosis

Presenter:

Dr. Judith A. Voynow, Edwin L. Kendig Jr. Professor, Virginia Commonwealth University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

[Ke Yuan]

2021 CALA Happy Friday Seminar

May 14^th , 2021

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321)  

Time: EST 10:30 am; PST: 7:30 am; Beijing time: 11:30 pm

 

Metabolic dysregulation during hyperoxic lung injury in bronchopulmonary dysplasia

 

Hongwei Yao PhD

Associate Professor
Brown University

         

          Dr. Yao is an Associate Professor of Molecular Biology, Cell Biology & Biochemistry at Brown University. His research interests include oxidative stress, inflammation, cellular senescence, mitochondrial dysfunction and metabolic reprogramming in chronic lung diseases such as neonatal bronchopulmonary dysplasia and adult chronic obstructive pulmonary disease. Dr. Yao is an author of over one hundred publications in peer-reviewed journals including JCI and PNAS. He has been serving as a member of several panels of federal grant study section including the NIH as an Ad-hoc. Dr. Yao was/is a member of the editorial boards of several journals, such as AJPLung, Physiological Reports, and Frontiers in Bioscience.

 

[Ke Yuan]

2021 CALA Happy Friday Seminar

May 14^th , 2021

Join Zoom Meeting: 

https://arizona.zoom.us/j/82407021221 (Password: 654321)  

Time: EST 10:30 am; PST: 7:30 am; Beijing time: 11:30 pm

 

Metabolic dysregulation during hyperoxic lung injury in bronchopulmonary dysplasia

 

Hongwei Yao PhD

Associate Professor
Brown University

         

          Dr. Yao is an Associate Professor of Molecular Biology, Cell Biology & Biochemistry at Brown University. His research interests include oxidative stress, inflammation, cellular senescence, mitochondrial dysfunction and metabolic reprogramming in chronic lung diseases such as neonatal bronchopulmonary dysplasia and adult chronic obstructive pulmonary disease. Dr. Yao is an author of over one hundred publications in peer-reviewed journals including JCI and PNAS. He has been serving as a member of several panels of federal grant study section including the NIH as an Ad-hoc. Dr. Yao was/is a member of the editorial boards of several journals, such as AJPLung, Physiological Reports, and Frontiers in Bioscience.

[Ke Yuan]

2021 CALA Happy Friday Seminar

May 14^th , 2021

Join Zoom Meeting: 

https://arizona.zoom.us/j/82407021221 (Password: 654321)  

Time: EST 10:30 am; PST: 7:30 am; Beijing time: 11:30 pm

 

Metabolic dysregulation during hyperoxic lung injury in bronchopulmonary dysplasia

 

Hongwei Yao PhD

Associate Professor
Brown University

         

          Dr. Yao is an Associate Professor of Molecular Biology, Cell Biology & Biochemistry at Brown University. His research interests include oxidative stress, inflammation, cellular senescence, mitochondrial dysfunction and metabolic reprogramming in chronic lung diseases such as neonatal bronchopulmonary dysplasia and adult chronic obstructive pulmonary disease. Dr. Yao is an author of over one hundred publications in peer-reviewed journals including JCI and PNAS. He has been serving as a member of several panels of federal grant study section including the NIH as an Ad-hoc. Dr. Yao was/is a member of the editorial boards of several journals, such as AJPLung, Physiological Reports, and Frontiers in Bioscience.

[Ke Yuan]

2021 CALA Happy Friday Seminar

May 14^th , 2021

Join Zoom Meeting: 

https://arizona.zoom.us/j/82407021221 (Password: 654321)  

Time: EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

 

Metabolic dysregulation during hyperoxic lung injury in bronchopulmonary dysplasia

 

Hongwei Yao PhD

Associate Professor
Brown University

         

          Dr. Yao is an Associate Professor of Molecular Biology, Cell Biology & Biochemistry at Brown University. His research interests include oxidative stress, inflammation, cellular senescence, mitochondrial dysfunction and metabolic reprogramming in chronic lung diseases such as neonatal bronchopulmonary dysplasia and adult chronic obstructive pulmonary disease. Dr. Yao is an author of over one hundred publications in peer-reviewed journals including JCI and PNAS. He has been serving as a member of several panels of federal grant study section including the NIH as an Ad-hoc. Dr. Yao was/is a member of the editorial boards of several journals, such as AJPLung, Physiological Reports, and Frontiers in Bioscience.

[Que, Jianwen]

Hi Ke,

Can you add Ya-Wen to our mailing list?

Ya-We...@med.usc.edu

Thanks,

Jianwen

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[Ke Yuan]

Title:

Engineering the Cellular and Extracellular Microenvironment of the Lung

June 11th 10:30am EST

Presenter:

Dr. Xi Ren, Assistant Professor, Carnegie Mellon University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

 

Abstract:

Dr. Ren received his BS and PhD from Peking University. He was trained as a developmental biologist in Harvard Medical School. Current research in his lab investigates and engineers two fundamental interactions (cell-cell and cell-ECM) during the biofabrication of functional tissues, in particular the lung. To recapitulate and investigate parenchymalnonparenchymal interaction and inter-organ crosstalk during organogenesis and regeneration, they develop strategies to enable simultaneous multi-lineage induction from human pluripotent stem cells. To engineer cell-ECM interaction, they develop chemoselective strategies to functionalize the native organ ECM to uncover how ECM biomolecular dynamics modulates tissue morphogenesis.

[Ke Yuan]

Title:

Engineering the Cellular and Extracellular Microenvironment of the Lung

June 11th 10:30am EST; 7:30am PST

Presenter:Dr. Xi Ren, Assistant Professor, Carnegie Mellon University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

 

Abstract:

Dr. Ren received his BS and PhD from Peking University. He was trained as a developmental biologist at Harvard Medical School. Current research in his lab investigates and engineers two fundamental interactions (cell-cell and cell-ECM) during the biofabrication of functional tissues, in particular the lung. To recapitulate and investigate parenchymal nonparenchymal interaction and inter-organ crosstalk during organogenesis and regeneration, they develop strategies to enable simultaneous multi-lineage induction from human pluripotent stem cells. To engineer cell-ECM interaction, they develop chemoselective strategies to functionalize the native organ ECM to uncover how ECM biomolecular dynamics modulates tissue morphogenesis.

[Ke Yuan]

2021 CALA Happy Friday Seminar

June 25^th, 2021

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321)

Time: EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

Title: The tumor suppressor PDLIM2 as a checkpoint of lung macrophages

Dr. Gutian Xiao
Professor of Microbiology and Molecular Genetics, School of Medicine
University of Pittsburgh

Abstract: Dr. Xiao is a professor at the University Of Pittsburgh School Of Medicine. He obtained his PhD at Fudan University, China. His research interests primarily focus on signaling transduction pathways in inflammation and carcinogenesis for the purposes of developing preventative and therapeutic measures.  Dr. Xiao has discovered the molecular mechanisms by which the canonical and noncanonical NF-κB signaling pathways collaborate for tumorigenesis.  Recently, he has demonstrated that PDLIM2 is an essential terminator of NF-κB and STAT activation as well as a novel NF-κB-dependent oncogene-NDO.  His on-going research seeks to elucidate molecular regulations and actions of PDLIM2 and NDO under physiological and oncogenic conditions by utilizing innovative mouse models.

 

[Ke Yuan]

周五讲座 now

Title:The tumor suppressor PDLIM2 as a checkpoint of lung macrophages

June 25th 10:30am EST; 7:30am PST Beijing 10:30pm

Presenter:

Dr. Gutian Xiao, Professor, University of Pittsburgh

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321)

[Ke Yuan]

2021 CALA Happy Friday Seminar

July 9th, 2021

Join Zoom Meeting:
https://arizona.zoom.us/j/82407021221 (Password: 654321)
Time: EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

SARS-CoV2 infection-associated endothelial injury 

Xuebin Qin, M.D., Ph.D.
Professor of Medicine
School of Medicine
Tulane University

Dr. Qin obtained his MD degree from Wannan Medical College and PhD degree from Peking Union Medical College & Chinese Academy of Medical Sciences, China. He has extensive expertise in immunology, the complement system, HIV-1 therapy, atherosclerosis, and cellular and molecular mechanisms. After the onset of COVID-19 in the USA in March 2020, Dr. Qin has developed and characterized murine COVID-19 models including Ad5-ACE2 delivery and K18-hACE2 transgenic mice. He is working to use these two models for conducting preclinical studies for evaluating therapeutic and vaccine activities against COVID-19 as well as for pathogenesis studies of COVID-19.

Abstract: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects lung epithelial cells, whether it also infects endothelial cells (ECs) and to what extent SARS-CoV-2-mediated pulmonary vascular endotheliitis is associated with immune activation remain to be determined. To address these questions, we studied SARS-CoV-2-infected K18-hACE2 (K18) mice, severe COVID-19 mouse disease, as well as lung samples from SARS-CoV-2-infected nonhuman primates (NHP) and patients with COVID-19. We show that SARS-CoV-2-infected K18 mice develop severe COVID-19, including progressive body weight loss and fatality at 7 days, severe lung interstitial inflammation, edema, hemorrhage, perivascular inflammation, systemic lymphocytopenia, and eosinopenia. Body weight loss in K18 mice correlated with the severity of pneumonia, but not with brain infection. We also observed endothelial activation and dysfunction in pulmonary vessels evidenced by the up-regulation of VCAM1 and ICAM1 and the downregulation of VE-cadherin. Using immunostaining, RNAscope, and electron microscopy, we detected SARS-CoV-2 in capillary ECs, activation and adhesion of platelets and immune cells to the vascular wall of the alveolar septa, and increased complement deposition in the lungs, in both COVID-19-murine and NHP models. Finally, bulk and single cell (sc) RNA-seq and cytokine profiling of the severe COVID-19 mice revealed that pathways of coagulation, complement, and K-ras pathways, and genes of ICAM1 and VCAM1 related to EC dysfunction and injury were upregulated, and were associated with massive immune activation in the lung and circulation. Together, our results indicate that the endotheliitis caused by both SARS-CoV-2 infection and infection-mediated immune activation contributes to the pathogenesis of severe COVID-19 disease.  

[Ke Yuan]

2021 CALA Happy Friday Seminar
July 9th, 2021
Join Zoom Meeting:
https://arizona.zoom.us/j/82407021221 (Password: 654321)
Time: EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm
SARS-CoV2 infection-associated endothelial injury 

Xuebin Qin, M.D., Ph.D.
Professor of Medicine
School of Medicine
Tulane University

Dr. Qin obtained his MD degree from Wannan Medical College and PhD degree from Peking Union Medical College & Chinese Academy of Medical Sciences, China. He has extensive expertise in immunology, the complement system, HIV-1 therapy, atherosclerosis, and cellular and molecular mechanisms. After the onset of COVID-19 in the USA in March 2020, Dr. Qin has developed and characterized murine COVID-19 models including Ad5-ACE2 delivery and K18-hACE2 transgenic mice. He is working to use these two models for conducting preclinical studies for evaluating therapeutic and vaccine activities against COVID-19 as well as for pathogenesis studies of COVID-19.

Abstract: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects lung epithelial cells, whether it also infects endothelial cells (ECs) and to what extent SARS-CoV-2-mediated pulmonary vascular endotheliitis is associated with immune activation remain to be determined. To address these questions, we studied SARS-CoV-2-infected K18-hACE2 (K18) mice, severe COVID-19 mouse disease, as well as lung samples from SARS-CoV-2-infected nonhuman primates (NHP) and patients with COVID-19. We show that SARS-CoV-2-infected K18 mice develop severe COVID-19, including progressive body weight loss and fatality at 7 days, severe lung interstitial inflammation, edema, hemorrhage, perivascular inflammation, systemic lymphocytopenia, and eosinopenia. Body weight loss in K18 mice correlated with the severity of pneumonia, but not with brain infection. We also observed endothelial activation and dysfunction in pulmonary vessels evidenced by the up-regulation of VCAM1 and ICAM1 and the downregulation of VE-cadherin. Using immunostaining, RNAscope, and electron microscopy, we detected SARS-CoV-2 in capillary ECs, activation and adhesion of platelets and immune cells to the vascular wall of the alveolar septa, and increased complement deposition in the lungs, in both COVID-19-murine and NHP models. Finally, bulk and single cell (sc) RNA-seq and cytokine profiling of the severe COVID-19 mice revealed that pathways of coagulation, complement, and K-ras pathways, and genes of ICAM1 and VCAM1 related to EC dysfunction and injury were upregulated, and were associated with massive immune activation in the lung and circulation. Together, our results indicate that the endotheliitis caused by both SARS-CoV-2 infection and infection-mediated immune activation contributes to the pathogenesis of severe COVID-19 disease.  

[Ke Yuan]

Title: Structural and signaling roles of alveolar type 1 cells 

Presenter: Jichao Chen, Ph.D., Associate Professor, MD Anderson Cancer Center

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: July 23th, 2021,

EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

CALA Webinar tomorrow!

Title: Structural and signaling roles of alveolar type 1 cells 

Presenter: Jichao Chen, Ph.D., Associate Professor, MD Anderson Cancer Center

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221(Password: 654321) 

Time: July 23th, 2021,

EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

See you this Friday at 10:30am(ET).Title: Structural and signaling roles of alveolar type 1 cells 

Presenter: Jichao Chen, Ph.D., Associate Professor, MD Anderson Cancer Center
Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: July 23th, 2021,

EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

9/10/21 周五 

10:30AM EST，7:30AM PST，

CALA Workshop 系列讲座，

邀请Xin Sun，Jianwen Que，Ting Xie讨论关于如何在肺领域发表高水平文章，如nature，science等杂志，敬请各位同事，朋友参加讨论。

如果您有问题参与讨论，请提前填写这个Google survey，https://docs.google.com/forms/d/e/1FAIpQLSd1wGbegaOUghoNAOwl4OozdxnYK9jFQ4H0Aph8GgG6K5f9JA/viewform?usp=sf_link,

或者把问题发到以下邮箱zhiy...@arizona.edu. 欢迎您的参与！

[Ke Yuan]

How to Publish High Impact Papers in the Lung Field

美中呼吸CALA  

Workshop Title: How to Publish High Impact Papers in the Lung Field

Time: September 10, 2021; EST 10:30am; PST: 7:30pm

Join Zoom Meeting:

Zoom ID: 824 0702 1221

Passcode: 654321

Panelists:

Xin Sun, PhD, University of California, San Diego, (published papers in Science, Nature, PNAS,...)

Jianwen Que, PhD, MD, Columbia University, (published Nature, Cell Stem Cell, JCI,...)

Ting Xie, PhD, Cedars-Sinai Medical Center, (published

Science Advances, Cell Rep,...)

On Thursday, September 2, 2021, Ke Yuan <yuank...@gmail.com> wrote:

9/10/21 周五 

10:30AM EST，7:30AM PST，

CALA Workshop 系列讲座，

邀请Xin Sun，Jianwen Que，Ting Xie讨论关于如何在肺领域发表高水平文章，如nature，science等杂志，敬请各位同事，朋友参加讨论。

如果您有问题参与讨论，请提前填写这个Google survey，https://docs.google.com/forms/d/e/1FAIpQLSd1wGbegaOUghoNAOwl4OozdxnYK9jFQ4H0Aph8GgG6K5f9JA/viewform?usp=sf_link,

或者把问题发到以下邮箱zhiyudai@arizona.edu. 欢迎您的参与！

[Ke Yuan]

It is Tomorrow

How to Publish High Impact Papers in the Lung Field

美中呼吸CALA  

Workshop Title: How to Publish High Impact Papers in the Lung Field

Time: September 10, 2021; EST 10:30am; PST: 7:30am

Join Zoom Meeting:

Zoom ID: 824 0702 1221

Passcode: 654321

Panelists:

Xin Sun, PhD, University of California, San Diego, (published papers in Science, Nature, PNAS,...)

Jianwen Que, PhD, MD, Columbia University, (published Nature, Cell Stem Cell, JCI,...)

Ting Xie, PhD, Cedars-Sinai Medical Center, (published

Science Advances, Cell Rep,...)

On Thursday, September 9, 2021, Ke Yuan <yuank...@gmail.com> wrote:

How to Publish High Impact Papers in the Lung Field

美中呼吸CALA  

Workshop Title: How to Publish High Impact Papers in the Lung Field

Time: September 10, 2021; EST 10:30am; PST: 7:30pm

Join Zoom Meeting:

Zoom ID: 824 0702 1221

Passcode: 654321

Panelists:

Xin Sun, PhD, University of California, San Diego, (published papers in Science, Nature, PNAS,...)

Jianwen Que, PhD, MD, Columbia University, (published Nature, Cell Stem Cell, JCI,...)

Ting Xie, PhD, Cedars-Sinai Medical Center, (published

Science Advances, Cell Rep,...)

On Thursday, September 2, 2021, Ke Yuan <yuank...@gmail.com> wrote:

9/10/21 周五 

10:30AM EST，7:30AM PST，

CALA Workshop 系列讲座，

邀请Xin Sun，Jianwen Que，Ting Xie讨论关于如何在肺领域发表高水平文章，如nature，science等杂志，敬请各位同事，朋友参加讨论。

如果您有问题参与讨论，请提前填写这个Google survey，https://docs.google.com/forms/d/e/1FAIpQLSd1wGbegaOUghoNAOwl4OozdxnYK9jFQ4H0Aph8GgG6K5f9JA/viewform?usp=sf_link,

或者把问题发到以下邮箱zhiy...@arizona.edu. 欢迎您的参与！

[Ke Yuan]

Today at 10:30am ET

How to Publish High Impact Papers in the Lung Field

美中呼吸CALA  3 days ago

[Ke Yuan]

Title: Cytosolic RNA Sensing Pathway Regulates Host Response to Mycobacterium tuberculosis Infection in Macrophages 

Presenter: Yong Cheng, Ph.D., Assistant Professor, Oklahoma State University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Oct 8th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

Speaker introduction: 

Dr. Cheng obtained his PhD degree in Microbiology at National Key Laboratory of Agricultural Microbiology, China and followed by training as a postdoc fellow at University of Basel, Switzerland and University of Notre Dame, Indiana. The current study of his lab is understanding the host-pathogen interactions during M. tuberculosis and nontuberculous mycobacteria (NTM) infections. Dr. Cheng has published many high impact papers in JEM, EMBO Rep, PloS Pathogens.

Abstract: Tuberculosis (TB) remains one of the most deadly infectious diseases in humans. The host immunity plays a critical role in controlling Mycobacterium tuberculosis (M.tb) infection and determining the outcome of M.tb infection. Our study identified that M.tb releases RNA into the macrophage cytosol through a mycobacterial SecA2 and ESX-1-dependent mechanism. Cytosolic M.tb RNA may be recognized by the RNA sensor RIG-I and stimulate the RIG-I/MAVS/TBK1/IRF7 signaling pathway, driving a robust INFβ expression synergistically with the STING-mediated DNA sensing pathway in macrophages. Additionally, we found that M.tb RNA can be packed into macrophage-derived extracellular vesicles during M.tb infection, and activate RIG-I/MAVS-dependent IFN-β production and LC3-associated phagolysosome maturation in recipient macrophages. In summary, our study indicates a critical role of the host MAVS-dependent RNA sensing pathway in host response to M.tb infection in humans.

[Ke Yuan]

Title: Cytosolic RNA Sensing Pathway Regulates Host Response to Mycobacterium tuberculosis Infection in Macrophages 
Presenter: Yong Cheng, Ph.D., Assistant Professor, Oklahoma State University
Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Oct 8th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

Speaker introduction: 

Dr. Cheng obtained his PhD degree in Microbiology at National Key Laboratory of Agricultural Microbiology, China and followed by training as a postdoc fellow at University of Basel, Switzerland and University of Notre Dame, Indiana. The current study of his lab is understanding the host-pathogen interactions during M. tuberculosis and nontuberculous mycobacteria (NTM) infections. Dr. Cheng has published many high impact papers in JEM, EMBO Rep, PloS Pathogens.

Abstract: Tuberculosis (TB) remains one of the most deadly infectious diseases in humans. The host immunity plays a critical role in controlling Mycobacterium tuberculosis (M.tb) infection and determining the outcome of M.tb infection. Our study identified that M.tb releases RNA into the macrophage cytosol through a mycobacterial SecA2 and ESX-1-dependent mechanism. Cytosolic M.tb RNA may be recognized by the RNA sensor RIG-I and stimulate the RIG-I/MAVS/TBK1/IRF7 signaling pathway, driving a robust INFβ expression synergistically with the STING-mediated DNA sensing pathway in macrophages. Additionally, we found that M.tb RNA can be packed into macrophage-derived extracellular vesicles during M.tb infection, and activate RIG-I/MAVS-dependent IFN-β production and LC3-associated phagolysosome maturation in recipient macrophages. In summary, our study indicates a critical role of the host MAVS-dependent RNA sensing pathway in host response to M.tb infection in humans.

[Ke Yuan]

This morning at 10:30am EST

Title: Cytosolic RNA Sensing Pathway Regulates Host Response to Mycobacterium tuberculosis Infection in Macrophages 
Presenter: Yong Cheng, Ph.D., Assistant Professor, Oklahoma State University
Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Oct 8th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

或者把问题发到以下邮箱zhiyudai@arizona.edu. 欢迎您的参与！

[Ke Yuan]

This Friday 10:30am  a seminar by Dr Chen

Please see the flyer for details.

或者把问题发到以下邮箱zhiy...@arizona.edu. 欢迎您的参与！

[Ke Yuan]

CALA Friday Seminar

Title: Laser facilitates sustained drug delivery and better vaccination

Presenter: Xinyuan Chen, Ph.D., Associate Professor,  University of Rhode Island

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Oct 22nd, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

Abstract: Sustained drug delivery systems are highly attractive to reduce dose frequency and reduce drug toxicity. Here we present laser-based powder drug delivery systems to achieve 12-hr, 3-day or week-long sustained drug delivery across the skin. Such systems are based on laser treatment to generate skin microchannels followed by topical application of powder-coated patches to deliver drug into the skin via skin microchannels. Based on patch design, different duration of drug delivery can be achieved. We further found laser-based powder delivery at relatively strong laser conditions could be used for more immunogenic vaccination when compared to needle-based injection delivery. The laser-based powder delivery of influenza vaccine was found to elicit more potent antibody responses and protection than needle-based injection delivery in murine models. Further studies found laser treatment could induce significant thermal stress in microchannel-surrounding tissues, which release double-strand DNA to activate NLRP3 inflammsome and IL-1β release. Interestingly, double-strand DNA, NLRP3 inflammasome and IL-1β played a non-essential role and rather MyD88 played a crucial role in laser adjuvant effects. Our results indicate the laser-based powder delivery could alert innate immune systems for more immunogenic vaccination.

[Ke Yuan]

本周五讲座-Title: Laser facilitates sustained drug delivery and better vaccination 

Presenter: Xinyuan Chen, Ph.D., Associate Professor, University of Rhode Island

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Oct 8th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

Starting now.

本周五讲座-Title: Laser facilitates sustained drug delivery and better vaccination 

Presenter: Xinyuan Chen, Ph.D., Associate Professor, University of Rhode Island

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Oct 8th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

See the flyer for this Friday webinar.

[Ke Yuan]

CALA Happy Hour 在线讲座系列: Dr.Shitao Li

Title: Nuclear soluble cGAS senses DNA virus infection

 

Presenter: Shitao Li, Ph.D., Associate Professor, Tulane University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Nov 5th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

CALA Happy Hour 在线讲座系列: Dr.Shitao Li

Title: Nuclear soluble cGAS senses DNA virus infection

 

Presenter: Shitao Li, Ph.D., Associate Professor, Tulane University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Nov 5th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

M

CALA Happy Hour 在线讲座系列: Dr. Xuexian Yang

Title: T helper cells in airway inflammation

 

Presenter: Xuexian Yang, Ph.D., Associate Professor, University of New Mexico

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Nov 19th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 10:30 pm

[Ke Yuan]

Dear CALA members:



According to the Article VI in the “By-Laws of Chinese-American Lung Association (CALA)”, it is time to elect new Treasurer of CALA. As the current Chair of Nomination Committee, I would like to call for nomination or self-nomination of candidates for the next Treasurer of CALA.

Eligibility: Nominee must be a CALA Full Member.

Responsibility if elected: 1. Prepare agenda and record meeting minutes at each meeting. 2. Present a financial report at the Annual Board of Governors meeting and Annual Membership Meeting, 3. Attend to general affairs of the Association including By-Laws amendments, website maintenance, as well as other assignments from the President. 4. To serve as the next President-Elect, and then the next President. More details regarding the responsibilities of the Treasurer can be found in the attached “By-Laws of CALA” (http://mycala.org/by-laws.html).

Nomination procedure:  Nominations including self-nomination are invited.

 Please submit nominee’s name, institute, and email address by Nov 31 2021 to 

Ke Yuan email: yuank...@gmail.com

Thanks so much for your support.

[Ke Yuan]

This morning at 10:30am

CALA Happy Hour 在线讲座系列: Dr. Xuexian Yang

Title: T helper cells in airway inflammation

 

Presenter: Xuexian Yang, Ph.D., Associate Professor, University of New Mexico

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Nov 19th, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 11:30 pm

[Ke Yuan]

本周五讲座

Title: Decoding how vascular niche regulates lung and liver regeneration and repair

 

Presenter: Bi-Sen Ding, PhD, Senior Investigator, Sichuan University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Dec 3rd, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 11:30 pm

Speaker introduction: 

Dr. Bi-Sen Ding is a senior investigator at State Laboratory of Biotherapy, West China Second Hospital, Sichuan University. He received his bachelor from Nanjing University and Ph.D. in Pharmacology from the University of Pennsylvania. His research aims to uncover the microenvironmental regulation of organ regeneration and fibrosis. During his Ph.D. study at PENN and postdoc research at Howard Hughes Medical Institute, he elucidated that vascular endothelial cell produces paracrine (angiocrine) factors to instruct liver and lung regeneration and repair. These findings were published with him as the first author in journals “Cell”, “Nature”, “Blood”, “Am. J. Respir. Crit. Care Med.”, “Molecular Intervention”, and “Circulation”.

Dr. Ding initiated his independent research as tenure track Assistant Professor at Cornell University in 2013. Since then, his lab has uncovered that the pro-regenerative cues from the vascular endothelial cell can be subverted to promote fibrosis or tumorigenesis. Therapeutic targeting of this “maladaptive vascular niche” can enable the clinical strategy to promote organ regeneration and to block fibrosis and tumorigenesis. His ongoing research has further demonstrated that perivascular hematopoietic cells act jointly with endothelial cells to form “Hematopoietic-Vascular Niche” in organ repair. This divergent niche can differentially promote either regeneration or fibrosis/tumorigenesis in injured organs. These findings are published in “Nature”, “Cancer Cell”, “Nature Cell Biology”, “Nature Medicine”, “Cell Metabolism”, “Science Translational Medicine”, and “Developmental Cell” communicated by himself as senior author.

[Ke Yuan]

本周五讲座

Title: Decoding how vascular niche regulates lung and liver regeneration and repair

 

Presenter: Bi-Sen Ding, PhD, Senior Investigator, Sichuan University

Join Zoom Meeting:

https://arizona.zoom.us/j/82407021221 (Password: 654321) 

Time: Dec 3rd, 2021, EST 10:30 am; PST: 7:30 am; Beijing time: 11:30 pm