I managed to connect Loxone to Amazon echo and am able to control lighting with that.
But I had to setup it through additional openHAB server and it was also a main reason I wrote an openHAB plugin for loxone which was not available.
You can find information about how to setup openHAB on openHAB.org and about the plugin and integration with Alexa it here:
https://github.com/ppieczul/org.openhab.binding.LoxoneThere are also plugins for HomeKit and google home for openHAB available, so this may be an answer for you.
If there is something missing in the Loxone plugin to interact with them, I will be happy to add it.
Good luck
Pawel