Definitely opened a can of worms with this one. Â :)
I haven’t put much energy into my project for the past year and a half or so, but there have been quite a few lessons learned in this time that will be reflected in system changes.  And I feel like this year will likely see me putting effort back into the project.  My intention is still to remove the Loxone entirely.  That will leave me with a bespoke system built out of off-the-shelf components and interconnected with standard tech (Ethernet and 1-wire, mostly).  The core of the system will be an ARM SBC, like it is now but with the remaining Loxone functionality moved into my custom software.  The Loxone programming is just too much of a nightmare at the scale I need it.
For resale, I’ve accepted that a buyer will either jump onboard the idea and dyi spirit of what I’ve built, or will demand a discount so that they can hire a pro outfit to come in and replace it with something “professional” (and the associated maintenance contract).  The wiring in place is all home run and doing a replacement wouldn’t be difficult, so there is no obstacle to this.  Housing prices are still climbing, so oh well, I don’t care about the relatively small potential value hit.  And for me, having a bespoke system is oh sooooo preferable!
Collecting data from the house at this scale has really been extremely valuable. Â I now have on the order of 50GB of sensor and power consumption data, all easily queried via SQL (from TimescaleDB). Â In addition to being useful for figuring out how to improve the hvac, it has also spotted problems immediately after they happened (eg the water meter told me of a leak, the power monitor tells me when the heat pump failed to reset after a brown out, specific sensors let me know a hydronic valve failed, etc). Â The multichannel power monitor is also useful for attribution of power to uses such as a home business and work from home during the pandemic.
The latest addition to my system is a solar PV install, and I still need to write the software to pull the data from the data collection box that came with it.  My HomeKit integration has been working well for years, although it generally only gets used for a couple of specific things.  At this point I don’t really know what else I would want to integrate, but I do have a fair list of refinements, many of which are fancier automatic ways to detect and notify us of problems.  And when the hvac logic moves to my software it will include functionality that is just too hard to do via Loxone... one example: automatically exercising pumps and valves daily to avoid seizing.  Plus I have some ideas about how to use machine learning to improve efficiency.
Oh, and replacing the Loxone means ditching their app.  Fortunately in the past year the options for quickly building good mobile UI without a horrendous amount of effort have improved greatly.  So doing a web UI and an Apple UI is now much more feasible for me.  And I’ve determined that it’s performance will be vastly better than the existing app, which is frustratingly slow.