thats fine - you can build a system ready for go live
temp sensor and IRC for each room/zone, each linked to its respective actuator valve (radiator or ufh manifold)
IRC outputs are connected either by a ITC (integrated OR, heating curve) and its output linked to your boiler relay and pumps/zone valves where necessary
or manually ORd and linked to a separate heating curve (if desired) then onto your relay for boiler/pump/zone valves
depending on your plumbing, you may need one of the above per manifold/floor
the differences between ITC and manual setup are:
ITC the links between IRCs are invisible so keep your config file less cluttered, and its heating curve changes its temperature according to the heat demand, based on the m2 setting for each room
a manual setup has memory flags linked to the OR for boiler/pump/zone valves, and a manual heating curve is not affected by the number of zones demanding heat.
a heat curve is only relevant where you can adjust the temperature of water supply to your heating devices to compensate for external temperature (eg mixing valve for ufh or output of a buffer tank) or if you are planning to adjust the boiler temperature
adjusting boiler temperature with a manifold system is pointless as the manifold is thermostatic and always mixes down the water temperature anyway so boiler control is a waste of time
if you have hot water storage you need to keep the boiler hot enough to keep the hot water at 60degC or higher to stop legionella
boiler temperature control is dependent on having an interface you can control from loxone - usually these are proprietry and quite expensive
however, if you have an instant hot water system and a non-thermostatic ufh manifold or radiators, you can use boiler temperature control as your main weather compensation as it will not be fighting any other thermostatic control systems.
if you are planning to keep radiators for your refurb its worth looking at the sizing for radiators - usually they are rated at a water temperature of around 75 deg - the boiler is less likely to be in condensing mode, there is a risk of burns and also overshoot - if you resize the rads for a working temperature of between 40-55 degrees there will be an increase in efficiency with a condensing boiler, less burns risk and less chance of overshoot of the room temperatures.