I now have my ~12 zones of heating working with forced air, dampers on each duct, and Loxone Touch Pure in each room as the sensor. It seems to be working well, comfort wise!
The "Intelligent Room Controller" is a nice (but misnamed) block, with a neat UI. I use one for each room.
I'd like to have a better UI for seeing house-wide stats as well time histories of all zones overlaid. I think I've seen people make nice custom web pages for this. Is there anything in particular you'd recommend to get me started?