What operating system are you using and why that driver? Are you sure the cable uses a Prolific chipset?
There are four chipsets in common use and my personal experience is:
Prolific, eg. PL2303 - believed to be better now (I think I have a radio programming cable that uses one) but used to cause so many crashes and hangs I avoid like the plague, also because there are many fakes which won't work with the genuine driver. I'm guessing maybe that's what you've got and the CD contains a hacked driver for it but the Prolific download won't work.
FTDI, eg/ FT232xx - absolutely reliable but you won't get a legit one for under a tenner and fakes are bricked by recent drivers - my last resort as I don't like giving money to them since FTDIgate (google it)
Silicon Labs, eg. CP210x
- good solid replacement for FTDI, found on many Arduino/ESP8266 devices but itself being replaced by...
CH340 - the new kid on the block since FTDIgate, cheap, ubiquitous and rock solid
I can't be 100% without finding a virgin system but I think the latest version of Windows 10 1607 has FTDI, CH340 and possibly Silicon Labs support out of the box.
If you're using Windows and it can't find a driver for your cable when you connect then Device Manager will show an unknown device with a yellow exclamation mark. Right click and drill into the details tab where you'll find the Hardware IDs. Googling those should tell you what chipset it's using, then go to the manufacturer and download the driver.
If all that fails then do as drrk suggests and buy a legit FTDI cable from their online store (they're based near Glasgow) or if money's more of an issue than time, buy a CH340 cable from AliExpress.
JJ