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Karenina Belman
Background: Standard of care (SoC) for transfusion-dependent β-thalassemia (TDT) requires lifelong, regular blood transfusions as well as chelation to reduce iron accumulation. Objective: This study investigates the cost-effectiveness of betibeglogene autotemcel ('beti-cel'; LentiGlobin for β-thalassemia) one-time, gene addition therapy compared to lifelong SoC for TDT. Study design: Microsimulation model simulated the lifetime course of TDT based on a causal sequence in which transfusion requirements determine tissue iron levels, which in turn determine risk of iron overload complications that increase mortality. Clinical trial data informed beti-cel clinical parameters; effects of SoC on iron levels came from real-world studies; iron overload complication rates and mortality were based on published literature. Setting: USA; commercial payer perspective Participants: TDT patients age 2-50 Interventions: Beti-cel is compared to SoC. Main outcome measure: Incremental cost-effectiveness ratio (ICER) utilizing quality-adjusted life-years (QALYs) Results: The model predicts beti-cel adds 3.8 discounted life years (LYs) or 6.9 QALYs versus SoC. Discounted lifetime costs were $2.28 M for beti-cel ($572,107 if excluding beti-cel cost) and $2.04 M for SoC, with a resulting ICER of $34,833 per QALY gained. Conclusion: Beti-cel is cost-effective for TDT patients compared to SoC. This is due to longer survival and cost offset of lifelong SoC.
Benjamin Beaudet, General Manager of beti states : After having experimented with the first generation of Arma shuttles and having seen all the progress in the areas of operability of the second generation EVO, we are very happy to continue our collaboration with Navya with the acquisition of this shuttle. This change of vehicle allows us to move from experimentation to service pilots and will allow us to test our operation of future beti automated mobility networks.
beti will deploy this EVO shuttle as well as others to come as part of the RIMA project supported by France 2030, which aims to develop an Inclusive Network of Automated Mobility in the rural Crest & Val de Drôme area. As a reminder, as part of the RIMA project announced in November 2022, beti, Navya, Macif and Vinci Construction aim to deploy 7 autonomous vehicles, 4 of which will have no operator on board. For the first time, the partners will deploy Bluebus Autonom vehicles equipped with the Navya Pack and the Navya Drive and Navya Operate software bricks.
With already 2 Arma shuttles and several deployments to its credit, beti is a French operator highly committed to the development of autonomous sustainable rural transport with a perfect knowledge and understanding of the field. Together with Navya, they form a solid partnership to develop technologies and services that meet the needs of the market..
We are proud to have customers who support us over the long term and who contribute to the development of our technologies. With beti, we are already preparing the very first deployments of the Bluebus Autonom. The RIMA project will combine EVO autonomous shuttles and Bluebus Autonom on a 50 km2 route that integrates perfectly with existing road infrastructures.
Campers often decide to participate in the Beti Bike Bash race event. Registration for the Beti Bike Bash is separate from Little Bellas camp and should be done at www.betibikebash.com. You will receive a code for free or discounted race entry for participating in Little Bellas camp.