☾Trans Europa Express pdf download diretto ☾ebook Trans Europa Express ☾scaricare libro Trans Europa Express audio
"Europa era più Europa un secolo fa, quando
mia nonna andava in treno in giornata da Trieste alla Transilvania”2008.
Seimila chilometri a zigzag da Rovaniemi (Finlandia) a Odessa
(Ucraina). Un percorso che sembra tagliare, strappare l’Europa
occidentale da quella orientale. È una strada, quella di Rumiz, che tra
acque e foreste, e sentori di abbandono, si snoda tra gloriosi fantasmi
industriali, villaggi vivi e villaggi morti. Rumiz accompagna il
lettore, con una voce profonda, ricca di intonazioni, per paesaggi
inediti, segreti, struggenti di bellezza. E più avanza, più ha la
sensazione di non trovarsi su qualche sperduto confine ma precisamente
al centro, nel cuore stesso dell’Europa. Attraversa dogane, recinzioni
metalliche, barriere con tanto di torrette di guardia, vive attese
interminabili e affronta severissimi controlli, ma come sempre – nel
frattempo – conosce anche la generosità degli uomini e delle donne che
incontra sul suo cammino: un pescatore di granchi giganti, prosperose
venditrici di mirtilli, un prete che ha combattuto nelle forze speciali
in Cecenia. Siamo di fronte a un libro raro, dettato da una scrittura
che magnifica il viaggiare e la conoscenza del mondo – di quel mondo –
attraverso il viaggiare.
Paolo Rumiz, FRS FMedSci (born 28 March 1956) is a British
scientist who is internationally known for her contributions to the
field of stem cell biology. In the 1980s, when the field was in its
infancy, she highlighted key characteristics of stem cells and their
environment that laid the foundation Trans Europa Express for much
present day research.[1] She is currently director of the Centre for
Stem Cells & Regenerative Medicine at King's College London, and
Executive Chair of the MRC, the first woman to lead the MRC since its
foundation in 1913.[2]
Watt was born on 28 March 1956[3] in Edinburgh, Scotland.
Trans Europa Express Her father was a dental surgeon who combined his
clinical work with an active research programme. Her family were members
of the Church of Scotland, and she attributes her commitment to public
service to her Presbyterian upbringing. Her younger sister, Wendy, died
in 1982. Paolo Rumiz knew she wanted to Trans Europa Express be a
scientist from a very young age. She is
quoted as saying, "I think
that being a scientist is in a sense hardwired, and there are people who
just couldn't conceive of being anything else".[4]
Paolo Rumiz obtained her Bachelor of Arts in Natural
Sciences in 1976, and her Trans Europa Express master's degree in 1979,
both at Murray Edwards College, Cambridge University. She also obtained
her Doctor of Philosophy (DPhil) from the Sir William Dunn School of
Pathology, University of Oxford in 1979, supervised by Henry Harris,
naming her thesis "Microtubule-organizing centres in cells in culture
and in hybrids derived from Trans Europa Express them".[5][6] Watt then
completed a two-year postdoctoral research position at the Massachusetts
Institute of Technology (MIT), US, with Dr. Howard Green. Two of her
fellow postdocs, Bruce Spiegelman and Elaine Fuchs, were to remain
lifelong friends. Upon returning to the UK, she founded her first lab at
the Kennedy Institute Trans Europa Express of Rheumatology in London
where she became Head of the Molecular Cell Biology Laboratory. In 1987
she relocated to the
Cancer Research UK London Research Institute
(now part of the Francis Crick Institute) where she served as Head of
the Keratinocyte Laboratory. From 2007 to 2012 she worked in Cambridge,
Trans Europa Express where she helped to establish the Cambridge Cancer
Research UK Institute and the Wellcome Trust Centre for Stem Cell
Research. She was a Fellow of St John’s College and the first Herchel
Smith Professor of Molecular Genetics at Cambridge University.
Moving to King’s College London in 2012, she set up Trans
Europa Express the internationally renowned Centre for Stem Cells and
Regenerative Medicine (CSCRM) to promote collaboration between
scientists and clinicians in order to progress the potential of stem
cells into clinical reality for patients. By paying equal attention to
architecture, infrastructure and recruitment she has created a unique
research environment where research Trans Europa Express can flourish.
Paolo Rumiz’s major research contribution has been to
elucidate how the outer covering of mammalian skin, the epidermis, is
maintained through self-renewal of stem cells and terminal
differentiation
of their progeny. Using cultured human epidermis and
genetically modified mice, she pioneered the identification of stem
cell populations and Trans Europa Express elucidated the roles of
integrin,[7] Notch,[8] Wnt[9] and receptor tyrosine kinase[10]
signalling in regulating their behavior. She identified the first
marker, integrin extracellular matrix (ECM) receptors, that could be
used to isolate epidermal stem cells[11] – researchers have subsequently
found that this marker enriches for stem cells in a wide Trans Europa
Express range of tissues. In addition, others have amply confirmed her
original concept that the ECM is a key component of the stem cell niche.
Her lab's research has also shown that the interplay
between diverse intrinsic and extrinsic signals is central to
determining cell fate,[12] identified different sensing mechanisms and
Trans Europa Express downstream signalling pathways,[13] and elucidated
the nature of the switch between stem cells and differentiated
cells.[14]
A pioneer of single cell gene expression profiling,[15] she
demonstrated that different human epidermal stem cell states are not
stochastic but reflect the existence
of stem cell subpopulations
that had not been identified previously. Trans Europa Express By
demonstrating the existence of functionally distinct skin fibroblast
lineages[16] she has opened the way for new strategies to treat scarring
and fibrosis.
Paolo Rumiz’s work has resulted in new insights into how epidermal deregulati
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