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Fiona Watt, FRS FMedSci (born 28 March 1956) is a British
scientist who is internationally known for her contributions to the
field of stem cell biology. In the 1980s, when the field was in its
infancy, she highlighted key characteristics of stem cells and their
environment that laid the foundation Persone. Disegno passo dopo passo.
Ediz. illustrata for much present day research.[1] She is currently
director of the Centre for Stem Cells & Regenerative Medicine at
King's College London, and Executive Chair of the MRC, the first woman
to lead the MRC since its foundation in 1913.[2]
Watt was born on 28 March 1956[3] in Edinburgh, Scotland.
Persone. Disegno passo dopo passo. Ediz. illustrata Her father was a
dental surgeon who combined his clinical work with an active research
programme. Her family were members of the Church of Scotland, and she
attributes her commitment to public service to her Presbyterian
upbringing. Her younger sister, Wendy, died in 1982. Fiona Watt knew she
wanted to Persone. Disegno passo dopo passo. Ediz. illustrata be a
scientist from a very young age. She is
quoted as saying, "I think
that being a scientist is in a sense hardwired, and there are people who
just couldn't conceive of being anything else".[4]
Fiona Watt obtained her Bachelor of Arts in Natural
Sciences in 1976, and her Persone. Disegno passo dopo passo. Ediz.
illustrata master's degree in 1979, both at Murray Edwards College,
Cambridge University. She also obtained her Doctor of Philosophy (DPhil)
from the Sir William Dunn School of Pathology, University of Oxford in
1979, supervised by Henry Harris, naming her thesis
"Microtubule-organizing centres in cells in culture and in hybrids
derived from Persone. Disegno passo dopo passo. Ediz. illustrata
them".[5][6] Watt then completed a two-year postdoctoral research
position at the Massachusetts Institute of Technology (MIT), US, with
Dr. Howard Green. Two of her fellow postdocs, Bruce Spiegelman and
Elaine Fuchs, were to remain lifelong friends. Upon returning to the UK,
she founded her first lab at the Kennedy Institute Persone. Disegno
passo dopo passo. Ediz. illustrata of Rheumatology in London where she
became Head of the Molecular Cell Biology Laboratory. In 1987 she
relocated to the
Cancer Research UK London Research Institute (now
part of the Francis Crick Institute) where she served as Head of the
Keratinocyte Laboratory. From 2007 to 2012 she worked in Cambridge,
Persone. Disegno passo dopo passo. Ediz. illustrata where she helped to
establish the Cambridge Cancer Research UK Institute and the Wellcome
Trust Centre for Stem Cell Research. She was a Fellow of St John’s
College and the first Herchel Smith Professor of Molecular Genetics at
Cambridge University.
Moving to King’s College London in 2012, she set up
Persone. Disegno passo dopo passo. Ediz. illustrata the internationally
renowned Centre for Stem Cells and Regenerative Medicine (CSCRM) to
promote collaboration between scientists and clinicians in order to
progress the potential of stem cells into clinical reality for patients.
By paying equal attention to architecture, infrastructure and
recruitment she has created a unique research environment where research
Persone. Disegno passo dopo passo. Ediz. illustrata can flourish.
Fiona Watt’s major research contribution has been to
elucidate how the outer covering of mammalian skin, the epidermis, is
maintained through self-renewal of stem cells and terminal
differentiation
of their progeny. Using cultured human epidermis and
genetically modified mice, she pioneered the identification of stem
cell populations and Persone. Disegno passo dopo passo. Ediz. illustrata
elucidated the roles of integrin,[7] Notch,[8] Wnt[9] and receptor
tyrosine kinase[10] signalling in regulating their behavior. She
identified the first marker, integrin extracellular matrix (ECM)
receptors, that could be used to isolate epidermal stem cells[11] –
researchers have subsequently found that this marker enriches for stem
cells in a wide Persone. Disegno passo dopo passo. Ediz. illustrata
range of tissues. In addition, others have amply confirmed her original
concept that the ECM is a key component of the stem cell niche.
Her lab's research has also shown that the interplay
between diverse intrinsic and extrinsic signals is central to
determining cell fate,[12] identified different sensing mechanisms and
Persone. Disegno passo dopo passo. Ediz. illustrata downstream
signalling pathways,[13] and elucidated the nature of the switch betwee
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