Merry On A Cross
Martin Glow
This festive cross stitch pattern collection by Shannon Christine Designs contains three separate charts that you can combine any way you choose. Stitch them vertically to make a pretty banner, or arrange them in a horizontal row. Alternatively, you can stitch each one separately and frame them individually. The choice is yours!
The designs are available as printed hardcopy patterns. If you want to get up and stitching quickly, save yourself the time of collecting all the supplies and purchase one of our bundle options which includes the pattern along with fabric, thread, and needles.
God Rest Ye Merry Gentlemen cross stitch pattern by Lindy Stitches. The cutest sleepy Christmas scene. This is always what I picture in my head when I sing this familiar carol! This is a cute, quick stitch using only a few overdyed flosses, easily substituted for DMC if you wish. Finished with some scrumptious Lady Dot trims.
This chart is so much fun! I really love the colors and that the snoring gentlemen are such a non-traditional take on such a traditional song! Shipping was super fast and I received the chart in great condition. Not my first purchase from here and certainly won't be my last!
Merry joined the Blue Cross NC Foundation in 2016. She is a seasoned strategist, program designer, project manager, evaluator, and communicator. She has been working for more than 20 years to improve health and well-being throughout the country with leading foundations, universities and, research organizations such as the Robert Wood Johnson Foundation, California HealthCare Foundation, Duke University, RTI International, and as an independent consultant to foundations, nonprofit organizations, and health systems. Merry earned her undergraduate degree from the University of North Carolina at Chapel Hill.
What I love about my work:
I am deeply committed to contributing to the changes needed to help ensure everyone has a fair chance for good health, in North Carolina, across our country, and in the larger world. I believe that authentic collaboration is key for creating effective and lasting change. Here at the Foundation, I love that, at the end of the day, I get to develop deep relationships and partnerships with an incredible variety of people and organizations to help build a food system that is healthy, accessible, affordable, and fair for everyone in North Carolina.
Blue Cross and Blue Shield of North Carolina and Blue Cross and Blue Shield of North Carolina Foundation are independent licensees of the Blue Cross and Blue Shield Association (BCBSA) Registered Marks of the BCBSA.
In Andrea di Bartolo: Way to Calvary an anguished Mary stretches out her hand towards her son. She almost looks as if she is trying to help raise up the weight of the cross. Here, although a soldier tries to push him forward, Jesus turns to look back over his shoulder. He gazes lovingly at his mother and does not turn away his face.
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Methods: This was a secondary analysis of a cross-sectional survey -'Youth2000' (New Zealand national survey of youth health). A total of 9567 secondary school students aged 12-18 years participated in the survey. The main outcome measures were self-reported acne, depressive symptoms (Reynolds Adolescent Depression Scale > 77), anxiety (Anxiety Disorder Index from Multidimensional Anxiety Scale for Children) and self-reported suicide attempts.
Conclusion: Young people presenting with acne are at increased risk of depression, anxiety and suicide attempts. Attention should be paid to their mental health, and the importance of asking directly regarding suicide is emphasised.
The effect of the perpetually renewing work of Patras is strong. The village of the dead is loquacious, its dwellers talk with the ease and humor of the living Sapanta people. Each of them would like to be visited and invites you to recognize or to discover her/him.
So, the crosses in Sapanta came to include painted representations of those buried underneath. The blue village of the dead, with its cross-houses, gained overnight, due to Stan Ion Patras, the windows through which one could take a glimpse of the personalities of those who had come to dwell in it.
N2 - AimsVascular calcification is a major cause of morbidity and mortality. Fibroblast growth factor-2 (FGF-2) plays an instructive role in osteogenesis and bone development, but its role in vascular calcification was unknown. Therefore, we investigated the involvement of FGF-2 in vascular calcification and determined the mechanism by which it regulates this process.Methods and resultsWe demonstrate that FGF-2 expression is increased in vascular smooth muscle cells (VSMCs) induced to deposit a mineralized matrix by incubation with β-glycerophosphate. FGF-2 is also localized to sites of calcification within human atherosclerotic plaques. The expression of syndecan-4, a heparan sulfate proteoglycan which regulates FGF-2 signalling, is also increased in mineralizing VSMCs and co-localizes with FGF-2 in human calcified atherosclerotic plaques. Exogenous FGF-2 inhibits VSMC mineralization, and this inhibition is reduced when syndecan-4 expression is knocked-down using siRNA. Biochemical inhibition of FGFR signalling using a pan FGFR inhibitor (BGJ398) or knocking-down syndecan-4 expression in VSMCs using siRNA increases VSMC mineralization. These increases are prevented by inhibiting transforming growth factor-β (TGFβ) signalling with SB431542, suggesting cross-talk between FGF-2 and TGFβ signalling is crucial for the regulation of VSMC mineralization. Syndecan-4 can also regulate FGF-2 signalling directly via protein kinase Cα (PKCα) activation. Biochemical inhibition of PKCα activity using G6976, or siRNA-mediated suppression of PKCα expression increases VSMC mineralization; this increase is also prevented with SB431542. Finally, the ability of FGF-2 to inhibit VSMC mineralization is reduced when PKCα expression is knocked-down.ConclusionThis is the first demonstration that syndecan-4 promotes FGF-2 signalling, and in turn, suppresses VSMC mineralization by down-regulating TGFβ signalling. Our discoveries that FGF-2 and syndecan-4 expression is increased in mineralizing VSMCs and that PKCα regulates FGF-2 and TGFβ signalling in VSMCs suggests that the syndecan-4/FGF-2/TGFβ signalling axis could represent a new therapeutic target for vascular calcification.
AB - AimsVascular calcification is a major cause of morbidity and mortality. Fibroblast growth factor-2 (FGF-2) plays an instructive role in osteogenesis and bone development, but its role in vascular calcification was unknown. Therefore, we investigated the involvement of FGF-2 in vascular calcification and determined the mechanism by which it regulates this process.Methods and resultsWe demonstrate that FGF-2 expression is increased in vascular smooth muscle cells (VSMCs) induced to deposit a mineralized matrix by incubation with β-glycerophosphate. FGF-2 is also localized to sites of calcification within human atherosclerotic plaques. The expression of syndecan-4, a heparan sulfate proteoglycan which regulates FGF-2 signalling, is also increased in mineralizing VSMCs and co-localizes with FGF-2 in human calcified atherosclerotic plaques. Exogenous FGF-2 inhibits VSMC mineralization, and this inhibition is reduced when syndecan-4 expression is knocked-down using siRNA. Biochemical inhibition of FGFR signalling using a pan FGFR inhibitor (BGJ398) or knocking-down syndecan-4 expression in VSMCs using siRNA increases VSMC mineralization. These increases are prevented by inhibiting transforming growth factor-β (TGFβ) signalling with SB431542, suggesting cross-talk between FGF-2 and TGFβ signalling is crucial for the regulation of VSMC mineralization. Syndecan-4 can also regulate FGF-2 signalling directly via protein kinase Cα (PKCα) activation. Biochemical inhibition of PKCα activity using G6976, or siRNA-mediated suppression of PKCα expression increases VSMC mineralization; this increase is also prevented with SB431542. Finally, the ability of FGF-2 to inhibit VSMC mineralization is reduced when PKCα expression is knocked-down.ConclusionThis is the first demonstration that syndecan-4 promotes FGF-2 signalling, and in turn, suppresses VSMC mineralization by down-regulating TGFβ signalling. Our discoveries that FGF-2 and syndecan-4 expression is increased in mineralizing VSMCs and that PKCα regulates FGF-2 and TGFβ signalling in VSMCs suggests that the syndecan-4/FGF-2/TGFβ signalling axis could represent a new therapeutic target for vascular calcification.
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