3-Bromopyruvate: possible cancer wonder drug

[Julian le Roux]

It appears that 3-bromopyruvate (3BP) may be an extremely effective and inexpensive treatment for most cancers, with minimal side effects. It's mechanism of action is well understood, and multiple academic journal articles from different research teams seem to confirm its anti-tumor properties. Please find below the list of links I found (I have tried to place the most useful/relevant ones at the top). The first Robb Wolf article is a long read, but I strongly recommend it. Note how much it echoes Mario's Daily Maverick piece from last week.

I find it utterly inexplicable that this compound has not already been tested on dozens of terminal cancer patients, even though its potential has been known to medical science for a decade. Of course, pervasive and onerous medical regulations (prohibition of unapproved drugs, patent law, medical licensing) shoulder most of the blame, directly and indirectly. Since 3BP cannot be patented, no pharmaceutical company is willing to fund the costly clinical trials which are required for FDA approval. Perhaps more importantly, if 3BP treatment were successful, it would eliminate the livelihoods, profits & prestige of tens of thousands of people in the medical establishment (virtually no expensive chemotherapy drugs, fewer oncologist appointments, fewer private and public cancer researchers)

Even so, I'm mildly shocked that no one around the world has attempted to find a way around these obstacles. Patients with no other option should be recommended 3BP...the proof of its efficacy (or lack thereof) could then be built up case-by-case, until the evidence is undeniable. Tens of millions of lives could potentially be saved in the time it takes for some controlled double-blind placebo blah blah clinical trial to be conducted, compiled and reported...and the FDA

The FDA and EMA are hopeless, but why aren't any developing countries stepping up to the plate (both for their citizens and medical tourism profits)?

Robb Wolf - The Origin of Cancer

http://www.singlecausesinglecure.org/

Bromopyruvic acid - Wikipedia, the free encyclopedia

War on cancer: 3BP and the metabolic approach to cancer: a visit with Peter Pedersen and Young Hee Ko. - Free Online Library

Dr. Peter Pedersen Explaining the Promise of 3-BP | Single Cause, Single Cure Foundation

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside - Springer

(Full PDF can be downloaded free)

3-Bromopyruvate (3BP) a fast acting, pro... [J Bioenerg Biomembr. 2012] - PubMed - NCBI

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors - Birsoy.PDF

3bp Cancer | Young researcher stalks cancer - Baltimore Sun

Cancer Biology & Therapy: News

PreScience Labs Announced that the FDA Accepts IND Application for Novel Oncology Drug | Reuters


Mitochondria in relation to cancer metas... [J Bioenerg Biomembr. 2012] - PubMed - NCBI

Experimental results using 3-bromopyruva... [J Bioenerg Biomembr. 2012] - PubMed - NCBI

3-bromopyruvate: a new targeted antigl... [Curr Pharm Biotechnol. 2010] - PubMed - NCBI

Intraarterial Therapy with a New Potent Inhibitor of Tumor Metabolism (3-bromopyruvate): Identification of Therapeutic Dose and Method of Injection in an Animal Model of Liver Cancer

0008-5472.CAN-12-1741.full.pdf

Cancer's Molecular Sweet Tooth and the Warburg Effect

doi:10.1016/j.bbrc.2004.09.047 - YHK_3BrPA_HCC_BBRC_plus_Suppor_Nov_05_2004.pdf

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

3-bromopyruvate: Targets and outcomes - Springer

Systemic administration of 3-bromopyruvate reveals its interaction with serum proteins in a rat model - 1756-0500-6-277.pdf

BMC Research Notes | Full text | Systemic administration of 3-bromopyruvate reveals its interaction with serum proteins in a rat model

Glycolytic Enzyme Inhibitors Affect Pancreatic Cancer Survival by Modulating Its Signaling and Energetics

Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity



US2013020315 ANTI-CANCER COMPOSITION AND METHOD UTILIZING 3-BP AND LIPOSOMAL REDUCED GLUTATHIONE

Patent US20070203074 - Composition and method for the efficacious and safe administration of ... - Google Patents

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER - Ko, Young Hee

US2007087740 THERAPEUTICS FOR CANCER USING 3-BROMOPYRUVATE AND OTHER SELECTIVE INHIBITORS OF ATP PRODUCTION

Patent US20130177630 - Anti-cancer composition and method utilizing 3-bp and liposomal reduced ... - Google Patents

All Anyone used 3bp (3-bromopyruvate)? messages

Cancer cure found by Dr Young Ko at JHU - 3-bromopyruvate 70c per day to treat people

3-bromopyruvate a miracle compound for certain cancer stuck in limbo

http://forum.bodybuilding.com/showthread.php?t=157739203

[Trevor Watkins]

Thanks very much for the reference to the Robb Wolf article - fascinating stuff. Your list of refs is also great. 

This touches on 3 of my favourite modern fallacies. 

1. Human understanding is advanced by vast research, vast funding, vast literature. In fact, in my observation, human understanding is most often advanced by individuals and small groups working outside the system.

2. It is unthinkable that a consensus of experts could be wrong. I suspect that the "experts" are wrong about the causes of cancer, AIDS, global warming, 9/11, Kennedy assassination, to name just a few. This article supports my thesis.

3. I have long argued that Darwin's theory does not fully explain evolution, and that epigenetics is involved. Fascinating that it should come up in this article too.

A suggestion. Setup a website like Kickstarter or Ushahidi to crowd source in a controlled manner reports of treatments and cures for various diseases. This could be used as a basis for turning endless accusations of "apocryphal", "isolated", "unsupported" into usable stats. Maybe bypass the FDA with a private, free alternative.

Trevor Watkins 

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[Julian le Roux]

Pleasure Trevor.

I mostly agree with you on the first point - just look at how superior Austrian economics (from just a few dozen principled thinkers) is to the mainstream.

I'm fairly sure the experts' consensus is correct when it comes to AIDS.

I don't see how the involvement of epigenetics detracts from Darwin's theory of evolution (i.e. evolution by natural selection). Can you provide links that support your assertion?

[rory kleu]

Hi Julian

 

I haven't been through all your links in detail, but in your searches have you come across John Beard's Trophoblast Cell Theory (involving Trypsin)? I have no idea if it can be useful or if it's a load of nonsense, but might be worth having a look at.

 

Then there is Jerry Brunetti who wrote a book "Cancer, Nutrition & Healing." He's a bit of an alternative character, but claims he cured himself of cancer using diet - again might be worth looking at.

 

Rory

Trevor Watkins 

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[Julian le Roux]

Hey Rory

No I didn't come across the trophoblast theory or Brunetti at all. Frankly, the initial results I get from Google definitely raise my bullshit meter. Perhaps you can point me to articles that look more solid.

What 3BP and the ketogenic diet have going for them is a clear hypothesis of how most cancers works, with decades of observations that fail to disprove it.

[Julian le Roux]

"A suggestion. Setup a website like Kickstarter or Ushahidi to crowd source in a controlled manner reports of treatments and cures for various diseases. This could be used as a basis for turning endless accusations of "apocryphal", "isolated", "unsupported" into usable stats."

@Trevor: I had precisely the same thought. Ridiculous really that this kind of system wasn't setup decades ago.

On Sun, Nov 10, 2013 at 10:02 AM, Trevor Watkins <bas...@gmail.com> wrote:

[rory kleu]

I couldn't find anything more solid either...

[Trevor Watkins]

I still have a few niggling queries about the consensus on AIDS. The difficulty in isolating the virus, the difficulty in developing a vaccine, the unusual epidemiology of the disease. Although the anti retrovirals appear to be successful, I suspect the mechanism is a lot like chemotherapy - if you kill enough stuff you will eventually also kill the bad stuff.

I first became interested in epigenetics (also known as Lamarckism, after an early proponent) after reading "The case of the midwife toad" by Kingsley Amis, a subtle and unusual murder mystery based on fact. I have read elsewhere that 3 billion years is insufficient time statistically for purely random mutations to result in life as we see it according to the Darwinian model. After much scorn being poured on Lamarck and others, the evidence for epigenetics was recently conclusively demonstrated.

Trevor Watkins - Base Software
bas...@gmail.com 083 44 11 721 - 042 293 1405 - (fax)0866 532 363
PO Box 3302, Jeffreys Bay, 6330

[Dewald Pieterse]

This morning I browse through my linkedin connections and then I see that a professor that I studied under is now also into researching glucose starvation of cancer among other things:
http://www.linkedin.com/profile/view?id=187721683&ref=PYMK&authType=name&authToken=iYGC&trk=new_pymk-profile
http://metabolist.wordpress.com/category/uncategorized/page/2/

--
Dewald Pieterse

"A democracy is nothing more than mob rule, where fifty-one percent of the people take away the rights of the other forty-nine." ~ Thomas Jefferson
http://www.jonathangullible.com/mmedia/PoL.English.The.Philosophy.of.Liberty.swf
“A ’chocolate king’ has no power over the consumers, his patrons. He provides
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not rule the consumers, he serves them. The consumers ... are free to stop
patronizing his shops. He loses his ’kingdom’ if the consumers prefer to
spend their pennies elsewhere.” Ludwig von Mises, Human Action