Alicense is an authorization from OFAC to engage in a transaction that otherwise would be prohibited. To apply for a license, click the link below or scroll down for more information on the different licensing categories.
If your funds have been blocked or "frozen" by a financial institution or other party due to a possible link to OFAC-administered sanctions, you may apply for a specific license by clicking the Apply for a License button above. Select "Release of Blocked Funds" as the application type on the first page of the application.
You may not need to apply for a specific license. Before applying for a specific license, please review the information about Cuba travel and the 12 categories of general licenses related to Cuba travel found in the Cuba Assets Control Regulations (31 CFR part 515). To the extent that your proposed travel falls within the scope of an existing general license, you may proceed without applying for a specific license from OFAC. General licenses constitute blanket authorization for those transactions set forth in the relevant regulation and are self-selecting and self-executing. Persons traveling pursuant to a general license do not need to notify OFAC of their travel plans. It is OFAC's policy not to grant applications for a specific license authorizing transactions where a general license exists.
If you determine that a general license does not apply, you may apply for a specific license by using this online application process. OFAC will consider the issuance of specific licenses on a case-by-case basis when a general license provision is not available. Please read all instructions and relevant information fully before submitting an application for a specific license.
For information related to licenses authorizing exports of agricultural commodities, medicine, and medical devices to Iran and Sudan pursuant to the Trade Sanctions Reform and Export Enhancement Act of 2000 (TSRA), please see our TSRA page, TSRA Frequently Asked Questions, and TSRA Application Guidelines.
This sounds like such a simple thing but I cannot figure out how to choose specific folders to automatically backup. When I get to the backup folder selection menu in the dropbox app I have half a dozen high level choices like "Desktop", "Downloads", and "Videos" to choose from but I don't want to automatically backup any of those, I want to backup specific folders like "C:\cygwin64\home\foo\bar" - how do I tell the app to do that? I'm on a Windows 11 PC.
You can't. The Backup feature only backs up the key folders of your operating system; Desktop, Documents, Downloads, etc, along with external drives. You can't specify other folders to be backed up. Also keep in mind that Dropbox can only sync files that are located in your Dropbox folder. The backup feature works by MOVING the key folders into your Dropbox folder so they can sync. It doesn't back them up in place.
>> the key folders of your operating system; Desktop, Documents, Downloads, etc, along with
external drives.
Whoever thought those are the "key folders of my operating system" made a very funny, naive and arrogant assumption.
When are you going to answer our questions?
Hello - I'm trying to set up Dropbox Backup but it won't let me select my own folders to back up. It gives me a list of folders to select from, but I want to incldue other folders (eg parts of Program Files). Is there a way to do this? I can't see a 'browse' option or similar. Many thanks.
The Backup feature only allows you to select folders that exist within your user folder, and even then, not all of them. It's meant to backup the key folders within your user profile (Desktop, Documents, Downloads, etc.).
Prostate-specific antigen, or PSA, is a protein produced by normal, as well as malignant, cells of the prostate gland. The PSA test measures the level of PSA in the blood. For this test, a blood sample is sent to a laboratory for analysis. The results are usually reported as nanograms of PSA per milliliter (ng/mL) of blood.
The blood level of PSA is often elevated in people with prostate cancer, and the PSA test was originally approved by the FDA in 1986 to monitor the progression of prostate cancer in men who had already been diagnosed with the disease. In 1994, FDA approved the PSA test to be used in conjunction with a digital rectal exam (DRE) to aid in the detection of prostate cancer in men 50 years and older. Until about 2008, many doctors and professional organizations had encouraged yearly PSA screening for prostate cancer beginning at age 50.
Beginning around 2008, as more was learned about both the benefits and harms of prostate cancer screening, a number of professional medical organizations began to caution against routine population screening with the PSA test. Most organizations recommend that individuals who are considering PSA screening first discuss the risks and benefits with their doctors.
Some organizations do recommend that men who are at higher risk of prostate cancer begin PSA screening at age 40 or 45. These include Black men, men with germline variants in BRCA2 (and to a lesser extent, in BRCA1), and men whose father or brother had prostate cancer.
There is no specific normal or abnormal level of PSA in the blood. In the past, PSA levels of 4.0 ng/mL and lower were considered normal. However, some individuals with PSA levels below 4.0 ng/mL have prostate cancer and many with higher PSA levels between 4 and 10 ng/mL do not have prostate cancer (1).
If someone who has no symptoms of prostate cancer chooses to undergo prostate cancer screening and is found to have an elevated PSA level, the doctor may recommend another PSA test to confirm the original finding. If the PSA level is still high, the doctor may recommend that the person continue with PSA tests and digital rectal exams (DREs) at regular intervals to watch for any changes over time (also called observation or watchful waiting).
If the PSA level continues to rise or a suspicious lump is detected during a DRE, the doctor may recommend additional tests to determine the nature of the problem. These may include imaging tests, such as magnetic resonance imaging (MRI) or high-resolution micro-ultrasound.
Alternatively, the doctor may recommend a prostate biopsy. During this procedure, multiple samples of prostate tissue are collected by inserting hollow needles into the prostate and then withdrawing them. The biopsy needle may be inserted through the wall of the rectum (transrectal biopsy) or through the perineum (transperineal biopsy). A pathologist then examines the collected tissue under a microscope. Although both biopsy techniques are guided by ultrasound imaging so the doctor can view the prostate during the biopsy procedure, ultrasound cannot be used alone to diagnose prostate cancer. An MRI-guided biopsy may be performed for patients with suspicious areas seen on MRI.
In the past, men with elevated PSA levels and no other symptoms were sometimes prescribed antibiotics to see if an infection might be causing the PSA increase. However, according to the American Urological Association, there is no evidence to support the use of antibiotics to reduce PSA levels in men who are not experiencing other symptoms.
Overtreatment exposes a person unnecessarily to the potential complications associated with prostate surgery and radiation therapy. These include urinary (e.g., urinary incontinence, or leaking of urine following surgery and increased frequency and urgency of urination following radiation), gastrointestinal (e.g., loose stools or, less commonly, rectal bleeding following radiation), and sexual side effects (loss of erections or decreased erections following both surgery and radiation).
The PSA test may give false-positive results. A false-positive test result occurs when the PSA level is elevated but no cancer is actually present. A false-positive test result may create anxiety and lead to additional medical procedures, such as a prostate biopsy, that can be harmful. Possible side effects of biopsies include serious infections, pain, and bleeding.
False-positive test results are common with PSA screening; only about 25% of people who have a prostate biopsy due to an elevated PSA level are found to have prostate cancer when a biopsy is done (2).
The PLCO investigators found that men who underwent annual prostate cancer screening had a higher incidence of prostate cancer than men in the control group but had about the same rate of deaths from the disease (3). Overall, the results suggest that many men were treated for prostate cancers that would not have been detected in their lifetime without screening. Consequently, these men were exposed unnecessarily to the potential harms of treatment.
A second large trial, the European Randomized Study of Screening for Prostate Cancer (ERSPC), compared prostate cancer deaths in men randomly assigned to PSA-based screening or no screening. As in the PLCO, men in ERSPC who were screened for prostate cancer had a higher incidence of the disease than control men. In contrast to the PLCO, however, men who were screened had a lower rate of death from prostate cancer (4, 5).
A subsequent analysis of data from the PLCO used a statistical model to account for the fact that some men in the PLCO trial who were assigned to the control group had nevertheless undergone PSA screening. This analysis suggested that the level of benefit in the PLCO and ERSPC trials was similar and that both trials showed some reduction in prostate cancer death in association with prostate cancer screening (6).
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