Discovery Studio 3.5
Gifford Brickley
I acquired my Analog Discovery Studio in June 2019 and this is the first time I am trying to use the +12, -12V, +V and -V power supplies. They are not working. The +3.3V and +5V power supply rails work great, and their LEDs come on as soon as I turn on their switches, but the +12, -12, +V and -V won't output any voltage even when enabled properly in waveforms and their LED's on the right side of the board won't turn on. I have tried it with Waveforms on a Macbook and on a MIcrosoft Surface, so it is not the software of the computer it is connected to via USB.
What version of the WaveForms software are you using? The switch only affects the output pins on the Canvas board (rather than the pins on the Analog Discovery Studio itself). I also presume you are using the provided 15V power supply to power the Analog Discovery Studio?
Thanks for your timely replies. I am indeed using the latest version of Waveforms (just downloaded this week) and the board is working find and being recognized by Waveforms no problem. I just figured out that the +12V, -12V, +V and -V outputs on the center top of the board indeed work just fine when enabled in Waveforms, so those must be the correct outputs. My original question is about the +12V, -12V, +V and -V output rails on the top right corner of the white breadboard area of the board, along with their corresponding physical switches to the right and their corresponding output LEDs further right on the breadboard. Can those output rails on the top right of the breadboard not be enabled at all? The physical "Walk Around" sheet I got with the board refers to only the Fixed and Variable Power Supplies on the black top center section of the board (i.e. the ones that work with Waveforms with no problems).
I am attaching a picture for clarity. The Power Supplies highlighted in yellow work just fine (labeled "OK" in the picture) but the ones circled in red (output rails, switches and their corresponding LEDs) do not produce any output.
Those pins on the breadboard should work; I just tested them on mine and everything works as expected. I didn't explicitly ask it before, but did you remove the small piece of foam from inbetween the Analog Discovery Studio and the Breadboard Canvas? Presuming the foam is removed (since that is where those power rails go into in the Breadboard Canvas and the 3.3V and 5V lines are apparently working), I'll likely need to tag in @attila for some additional debugging ideas.
JColvin - thank you so much! Indeed, I had not removed the small piece of foam in between the canvas and the studio. Once I removed it, those power supply rails, their switches and their LEDs worked perfectly as well. In the getting started instructions, I had understood the foam to be an external piece of foam that was in the packaging; it was not immediately apparent to me that the canvas was magnetically attached to the studio board and could be removed simply by pulling it up.
BIOVIA Discovery Studio brings together over 30 years of peer-reviewed research and world-class in silico techniques such as molecular mechanics, free energy calculations, biotherapeutics developability and more into a common environment. It provides researchers with a complete toolset to explore the nuances of protein chemistry and catalyze discovery of small and large molecule therapeutics from Target ID to Lead Optimization.
BIOVIA Discovery Studio offers a wide range of powerful tools that enable computational chemists and computational structural biologists to engineer stable and optimized novel biotherapeutics and small molecule drugs with desired safety profiles. Explore our tools supporting different areas of drug discovery.
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The Analog Discovery Studio is a fully functional, portable test and measurement device that can turn any cross-functional space into a pop-up electronics laboratory. Equipped with 13 instruments, including an Oscilloscope, Logic Analyzer, Spectrum Analyzer, Waveform Generator, and more; the Analog Discovery Studio provides an entire stack of bench-top instruments with a convenient, replaceable, and breadboardable interface, perfect for enabling student learning anywhere.
With lab spaces decreasing and student enrollment increasing, many institutions are choosing studio learning as a supplement to traditional laboratories, creating a need for a portable test and measurement bench that can support all types of circuits projects. With an Analog Discovery Studio, students can continue their hands-on learning in the library, office hours, a tutoring center, a classroom, at home or even in a coffee shop.
The Analog Discovery Studio is designed to be a compact alternative to a stack of benchtop equipment. Its durable enclosure measures 1.25 x 9.25 x 7.5 inches and fits on a bench, desktop, or backpack. Students can access the Oscilloscope and Waveform Generators via breadboardable MTE cables, or industry standard BNC cables, and the Logic Analyzer, Pattern Generator, and Triggers can be accessed via MTE cables.
Circuits or designs can be built on the included, magnetically connected Breadboard Canvas and conveniently swapped out or removed for transit, making the transition from working in the lab to working at home as seamless as possible. The Breadboard Canvas also includes power supply outputs controlled by physical switches, common I/O built-in, and a large breadboardable surface. The Breadboard Canvas and the cost-optimized Blank Canvas can be purchased separately in the event that an extra is needed, or if the breadboards wear out.
WaveForms is the free software application for the Analog Discovery Studio and enables use of the available analog and digital instruments. The software has been refined by customer feedback for over 10 years and features a computer and laptop friendly user interface that has the feel of traditional benchtop software. The Analog Discovery Studio communicates with WaveForms via a USB connection to your computer, allowing users to capture, record, analyze, and generate mixed signal and mixed domain waveforms. WaveForms can be downloaded and installed in under 60 seconds and can be tested without hardware using its demo mode feature. In addition to the use of instruments in the application, the WaveForms application has a script editor tool, which allows custom scripting of the instrument in JavaScript. WaveForms is designed to be run on a laptop or desktop computer and is Mac, Windows, and Linux compatible.
For even more customization potential, the WaveForms Software Development Kit (SDK) can be used to create custom applications and scripts in Python, C, and additional languages. The Analog Discovery Studio is also compatible with LabVIEW and the Digilent Toolbox for compatibility with MathWorks' MATLAB Data Acquisition Toolbox.
The resource center for the Analog Discovery Studio is the central hub of technical content for the device, and contains everything to get started and reduce mean time to test. This includes a Getting Started Guide, documentation, Tutorials on each instrument, example projects and a link to technical support.
Discovery Studio is a powerful software suite widely used for 3D molecular modeling, simulation, and visualization. It combines world-class in silico techniques and over 30 years of peer-reviewed research into a shared environment, providing molecular modelers with a complete toolset. With Discovery Studio, researchers can explore the nuances of protein chemistry and catalyze discovery of small and large molecule therapeutics from Target ID to Lead Optimization.
Discovery Studio Simulation, the cloud-based version, is available on the 3DEXPERIENCE platform, offering several benefits over the desktop version. First, it eliminates the need for hardware upgrades and installations, making it easier and more cost-effective for researchers to access the software. It also provides greater flexibility and scalability, allowing scientists to run multiple simulations simultaneously and scale up or down as needed. Finally, as a platform-based application, with Discovery Studio Simulation, users may access other applications on the 3DEXPERIENCE platform, supporting end-to-end small molecule drug discovery. These applications include:
For those who prefer an on-prem version, the latest major version has been released: Discovery Studio 2023 SP1, compatible with Pipeline Pilot 2023 SP1. Packed with novel features and enhancements, this latest version includes a new Gaussian accelerated Molecular Dynamics (GaMD) method for simultaneous unconstrained enhanced sampling and free energy calculations, a new machine learning method to humanize antibody sequences and more. We are also preparing for another release of Discovery Studio on-prem, to come before the end of the year.
Discovery Studio (DS) is a suite of software for modeling small and polymeric systems. It is developed and distributed by Dassault Systmes BIOVIA (formerly Accellrys). This product suite features a robust academic collaboration program that supports scientific research and leverages many software algorithms originally developed in the scientific community, including CHARMM, MODELLER, DELPHI, ZDOCK, DMol3, and more. Key capabilities of DS currently include protein characterization (including protein-protein interactions), homology modeling, molecular mechanics calculations, and molecular dynamics simulations, structure-based drug design tools (including ligand-protein interactions, new drug design), molecular docking, small molecule-based drug design tools (including quantitative structure-activity relationship, pharmacophore, database screening, ADMET), design and analysis of combinatorial libraries. DS can be applied to the following research areas of life sciences: new drug discovery, bioinformatics, structural biology, enzymology, immunology, virology, genetics, and tumor research.
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