To get rid of annoying problem in Texnic center + Miktex + Windows that we have to close the pdf file before re-running the tex file, I find solution in
TexNic center site.
http://www.texniccenter.org/news/118-syncing-with-pdf-files
You can go through the instructions given there, you have to install Subatra PDF viewer and change output profile settings Latex-PDF
The above change will be very much useful when you want to frequently edit your tex file and view the corresponding pdf output.
cheers
karthick