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Both the RasterPixelIsArea and RasterPixelIsPoint options should be expected by the application software and handled correctly. Otherwise is limited because it application will always have a problem dealing with geospatial data stored as TIFF or using GeoTIFF tags. The application should expect both options and adjust the data accordingly.
From, remotesensing.org, the creater of GeoTIFF tags:
What is the effect of PixelIsArea vs. PixelIsPoint?
Setting the GTRasterTypeGeoKey value to RasterPixelIsPoint or RasterPixelIsArea alters how the raster coordinate space is to be interpreted. This is defined in section 2.5.2.2 of the GeoTIFF specification. In the case of PixelIsArea (default) a pixel is treated as an area and the raster coordinate (0,0) is the top left corner of the top left pixel. PixelIsPoint treats pixels as point samples with empty space between the "pixel" samples. In this case raster (0,0) is the location of the top left raster pixel.
The net effect is a half pixel offset when interpreting PixelIsPoint vs. PixelIsArea images. There has been some confusion on the intepretation of this value in the GeoTIFF community for some time and some held the opinion that this parameter should have no effect on the georeferencing of the image. While this matter has been settled, the result is that some software packages, particularly those built on GDAL 1.7.x or older incorrectly interprete the georeferenced location of PixelIsPoint images - placing them offset by half a pixel. One way of avoiding compatability problems is to produce GeoTIFF files with the default PixelIsArea interpretation.
Regards,
Paul Beaty