Activity Designer Library Vs Activity Library PORTABLE
Terry Paredes
Synthesis of a new family of quinolylhydrazone derivatives and evaluation of their activity against a chloroquine-resistant strain of Plasmodium falciparum are described. The best compound displayed an activity 6-fold higher than chloroquine. None of the active compounds were found to inhibit beta-hematin formation in vitro in the same range as chloroquine and five among them displayed lower calculated vacuolar accumulation ratios, suggesting the implication of a different mechanism of action.
Arts-based social-emotional health activity for mindfulness and sensory-based learning. Create a garden of your own with homemade sensory paints. Discover how household items can transform into colorful fluffy, bubbly, and yummy-smelling paints.
An art-based social-emotional health activity for service-based learning. Discover how a talent show - no matter how big or small - can boost confidence, promote social inclusion, and create opportunities to show off the things we enjoy most.
I installed FormActivityLibrary, but there are no form activities in the activity navigator.
I tried to re-install and update to several versions, but no result.
Please let me know how can I solve this problem.
Comparative performance of the Avana library. (a) Distribution of Rule Set 1 scores across libraries. The box represents the 25th, 50th, and 75th percentiles, whiskers show 5th and 95th percentiles. (b) Comparison of the FDR-corrected q-values determined by STARS for the top 100 ranked genes in the vemurafenib resistance assay in A375 cells. (c) Validation of individual sgRNAs for vemurafenib resistance in a competition assay in A375 cells. Horizontal bars represent the average of the individual sgRNAs for each gene. Previously-validated genes are labeled in blue. ETP = early time point. (d) Subsampling analysis of the Avana library. We first identified genes that passed at different FDR thresholds with STARS when all six subpools were analyzed (first number in legend), the average number of retained genes that score at different FDR thresholds following removal of subpools (second number in legend). LG = lentiGuide; LC = lentiCRISPRv2. (e) ROC-AUC analysis of individual sgRNAs targeting core essential genes in dropout screens in A375 cells. AUC values are indicated in parentheses.
Tiled library screen for resistance genes. (a) Performance of sgRNAs by gene for each of three small molecule challenges. The box represents the 25th, 50th, and 75th percentiles, whiskers show 5th and 95th percentiles, and outliers are shown as individual dots. (b) For sgRNAs targeting MED12, comparison of the log2-fold-change when challenged with vemurafenib and selumetinib. (c) Activity of sgRNAs as a function of target site within the protein, divided by deciles, for 17 proteins. The box represents the 25th, 50th, and 75th percentiles, whiskers show 10th and 90th percentiles. The final decile has a statistically-significant difference in activity (adjusted p-values < 0.02, one-way ANOVA with repeated measures, with Tukey's correction for multiple comparisons).
On-target and off-target properties of the Brunello and Brie libraries. (a) Distribution of Rule Set 2 on-target activity scores across libraries. The box represents the 25th, 50th, and 75th percentiles, whiskers show 5th and 95th percentiles. (b) Cumulative distribution of the number of off-target sites with CFD scores > 0.2 in protein-coding regions across human libraries and (c) mouse libraries.
We thank M. Tomko, M. Greene, A. Brown, D. Alan, and T. Green for software engineering support, and T. Nguyen, N. Tran, and X. Yang for library production support (Broad Institute). Z.T. is funded by NIH 5K12CA087723-12, ASCO Young Investigator Award, LLS Special Fellow Award. J.G.D. is a Merkin Institute Fellow and is supported by the Next Generation Fund at the Broad Institute of MIT and Harvard.
The Engagement & Outreach Division of the Auburn Public Library offers a variety of programming for all ages including storytimes, puppet shows, author visits, book groups, and more! Please join us to sing, laugh, and explore inside the library, in our Outdoor Literacy Theater, or virtually through Zoom. Click on any item in the calendar below to learn more about the program & access Zoom links where available.
An arched doorway guides visitors into the main lobby of library, featuring Mission-style architecture and furniture throughout the building. In designing the space, architect M. W. Rusty Coombs took inspiration from the Spanish Revival and Craftsman movements. The library opened in 2006 with an environment focus, constructed using recycled materials and with native plant landscaping. A fenced-off area behind the library is home to a sensitive habitat for vernal pools. Several patios, a community room and seminar room provide space for special events and large gatherings. In addition, the library features an outdoor play area designed in cooperation with First 5 San Diego.
The area of graphic design has expanded since digital media was introduced, and it requires new creative thinking skills in the design process. This paper proposes a design process for a graphic design graduate class using activity theory as a theoretical background. This design process consists of three phases to solve the design problems within diverse design projects. Each phase was examined in terms of how the elements of activity theory could apply to the design process. As a research method, EngestrÃm's activity system model was adapted and explored in the design processes. A case study is presented to see how the proposed design process applied to a design project.
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Due to a contract conflict between two software vendors, our DC Public Library app is currently experiencing functionality limitations, particularly with the "Search the catalog" and "Popular Titles" features located at the top. The vendors are working to resolve this issue as soon as possible. The library's catalog can still be accessed via our website both on mobile and on desktop, for your convenience. Other digital resources available through your DC Public Library card, such as Libby and Overdrive remain unaffected by this issue.
One of the first neighborhood libraries when it opened in 1922, this Capitol Hill branch serves a diverse and vibrant community that is also home to the similarly historic Eastern Market. This library will be fully modernized. The last day of service for this location will be Thursday, Jan. 4, 2024. Customers will have a variety of interim services available to them during the renovation. Click on the renovation story at the bottom of the page to learn more.
DC Public Library is modernizing the Southeast Library. DC Public Library has hired the design/build team of Whiting-Turner Construction/Quinn Evans Architects for the $33 million transformation of this historic Carnegie library. The design will be a blend of preservation, renovation and rehabilitation. The last day of service for the Southeast Library will be Thursday, Jan. 4. Customers will have access to a variety of interim services during the renovation. Learn more by clicking the button below.
The Southeast Library is being modernized. The design for the $33 million transformation of this historic Carnegie library is now complete. The renovated library will include expanded space for children, teens and adults, more space for books, computers and seating, preservation and restoration of the building's historic elements, a universally accessible entrance, restoring the exterior landscape, environmentally sustainable design and more meeting, collaboration, and study space
In chapter 2, we try to develop a new method to achieve O-GalNAc glycan from cell. Protein O-glycosylation is a universal post-translational modification that plays an essential role in many biological regulations. Recently we reported a technology termed Cellular O-Glycome Reporter/Amplification (CORA) to amplify and profile mucin-type O-glycans from living cells. However, the application and development of the CORA method is litmted by the precursor function. Here we described a rapid parallel synthesis of cellular O-glycome precursors via microwave assisted reaction. In total, 26 Ac3GalNAc-α-Bn derivatives, including fluorescent and other reactive functional groups, were successfully synthesized. Furthermore, subsequent activity screening and evaluation of these precursor toward living cell and T-synthase were performed.
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