Leonardo Stem

[Gigí Ruais]

Dr. Morsut is developing synthetic biology approaches for mammalian multicellular systems. His laboratory is engineering synthetic cell-cell communication pathways to advance tissue engineering applications as well as the fundamental understanding of multicellular dynamics.

Our lab invents and uses synthetic biology tools and approaches to build tissues in the lab. With a blend of protein engineering, stem cell biology, computational modeling and tissue engineering, we program cells to build tissues of desired structure and function in an iterative research cycle that increases our understanding of basic tissue biology principles as well as produces useful products for regenerative medicine.

On another level, the mission of the lab is training the next generation of scientists and leaders in the field of regenerative medicine. The lab is committed to generating the best work environment to make the best science possible, and to foster multidisciplinary research using expertise from engineering, developmental biology, medical science and computer science.

While this breakthrough earned Morsut a position at USC Stem Cell, his wife Sabina also accepted a postdoctoral fellowship in art history at USC and the couple, who originally met when they were 12 years old in Padova, will welcome their second child this June.

At USC, Morsut plans to use synNotch to direct the differentiation of stem cells into blood vessels that can support engineered organs, as well as develop additional synthetic biology tools, and said he looks forward to collaborating with researchers at the USC Viterbi School of Engineering and the USC Michelson Center for Convergent Bioscience, slated to open in fall 2017.

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Biophysical signals act as potent regulators of stem cell function, lineage commitment, and epigenetic status. In recent years, synthetic biomaterials have been used to study a wide range of outside-in signaling events, and it is now well appreciated that material cues modulate the epigenome. Here, we review the role of extracellular signals in guiding stem cell behavior via epigenetic regulation, and we stress the role of physicochemical material properties as an often-overlooked modulator of intracellular signaling. We also highlight promising new research tools for ongoing interrogation of the stem cell-material interface.

A key player in Aerospace, Defence and Security, Leonardo covers every possible operating scenario: air, land, sea, space and cyberspace. We invest in technologies that can benefit both military and civilian markets, developing dual-use and multi-functional systems for a variety of applications.

At Leonardo we are excited to be hosting our fourth cohort with the STEM Returners Programme. We know there is a large pool of skills and talent looking to return to work and we are ready to support you in taking that step.

We offer an array of exciting roles across our UK sites, with flexible working options to help you achieve the perfect balance between career and home-life and to ensure your smooth transition back to the workplace. We are looking forward to hearing from you and welcoming you to our company.

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Across CSUMB, people work together, fostering a strong sense of community. CSUMB stood out because of the project description, which includes an academic cohort initiative which supports the success of underserved students in the sciences. I understand the difficulty of transitioning from high school to college, and I wanted to provide students the support to navigate the CSU System. Initially, I was nervous about moving to a new environment, but my team has supported me throughout my service year and has enabled me to impact change.

A board-certified physician in Regenerative and Anti-Aging Medicine, Dr. Gonzalez holds a prestigious certification from the American Academy of Anti-Aging Medicine (A4M). He has also earned a Diplomate in Integrative Cancer Therapy Fellowship from A4M and is specializing in Integrative and Metabolic Medicine at George Washington University.

As the Scientific and Medical Director at theInternational Stem Cell Institute in Bogota, Dr. Gonzalez is at the forefront of groundbreaking research and advancements in the field. He has served as the president of both the Latin American Academy of Anti-Aging Medicine and the Colombian Association of Regenerative and Anti-Aging Medicine, demonstrating his leadership and commitment to this rapidly evolving field.

Currently engaged in multiple stem cell research projects, Dr. Gonzalez has developed collaborative relationships with several Stem Cells and Gene Therapy companies. His work focuses on expanding and reprogramming umbilical cord tissue-derived neural stem cells for the treatment of neurodegenerative diseases, and Whartons Jelly Mesenchymal Stem Cells for the treatment of various degenerative diseases, including diabetes, multiple sclerosis, and arthritis.

A graduate of the National University of Colombia, Dr. Leonardo Gonzalez is a leading figure in regenerative medicine, inspiring change and innovation in healthcare. Through his expertise, dedication, and passion, he continues to make a significant impact on the lives of patients and the future of medicine.

We use nanoscience to make STEAM more than just an acronym, but a daily practice. With support from a 2014 NISE Network Mini-Grant, our campers will get the chance to interact with female professionals in science, art, and technology who will act as mentors and role models. Participants will also be asked to use what they learn in order to create a new nano-oriented board game, which they will prototype in another camp that runs simultaneously with Girls Full STEAM Ahead.

This camp is geared toward achieving a variety of goals: engaging young females in science and technology, determining which nano activities and lessons resonate with respective age groups, and creating a safe space for creativity and innovation. The Leonardo is implementing the TBI (Team-Based Inquiry) approach in order to focus on and achieve the second goal. By developing a game based on nanoscience, the girls will be exhibiting which activities they found were most significant. By prototyping on the younger campers in a separate camp, we can see what concepts and activities work with which age group. We also plan to incorporate small surveys and observations which will further support our findings.

These goals and findings work toward the larger vision that we all, as educators, surely share: spreading the word about nano, and STEM (or STEAM!) at large. To learn more about The Leonardo and its unique approach to education, please visit www.theleonardo.org, or contact Tim Hecox from Oregon Museum of Science and Industry, and the West Regional Hub Leader.

The National Informal STEM Education Network (NISE Network) is a community of informal educators and scientists dedicated to supporting learning about science, technology, engineering, and math (STEM) across the United States.

The NISE Network is supported by multiple sources of funding - learn more. Except where otherwise noted all materials are licensed under a Creative Commons license, as per the Use and Privacy statement and Legal Notice.

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Stress during early life has been consistently associated with mental illness in adulthood1,2,3, though the mechanisms underlying the persistent effects are poorly understood. In humans and in rodent experimental systems, early life stress (ELS) exposure can have detrimental consequences on adulthood hippocampal functioning, for instance dysregulation of stress reactivity, impairments in spatial learning and memory, and increases in anxiety behavior2,4,5,6,7. Indeed, the rodent hippocampus undergoes anatomic and cellular changes in response to stress exposure8,9,10 and hippocampal volume is reduced in humans who have experienced ELS11,12. Stress decreases adult hippocampal neurogenesis, which occurs in the dentate gyrus (DG)13. Interestingly, decreases in adult neurogenesis correlate with poorer functioning in hippocampal-dependent memory tasks5,14, suggesting that deficits in neurogenesis may underlie the ELS-induced cognitive impairments.

In fact, both early life stress and chronic adulthood stress alter DG cell proliferation during the stress exposure5,15,21,22,31,32,34,35,36,37. However, interfering with stem cell division during the early postnatal period, but not later in life, leads to depletion of adult stem cells38,39, suggesting that the early postnatal period is critical for generating the adult stem cell pool. One intriguing and remarkably simple possibility for how ELS produces life-long DG dysfunction is that it interferes with stem cell division and DG assembly during their most active periods. However, while the effects of ELS on adult neurogenesis have been explored, the effects on stem cells have received almost no attention in the ELS literature.

To understand how ELS affects DG development, we first characterized DG anatomy at the end of the first (P7) and second postnatal (P14) weeks by assessing DG volume, stem cell proliferation, and distribution of progenitor and proliferating cells. DG neural stem cells (NSCs) are radial glial-like cells that express glial fibrillary acidic protein (GFAP) and Nestin13,23,42,43. They divide giving rise to Nestin-expressing non-radial intermediate progenitor cells, which differentiate into neuroblasts. Neurons that develop from this lineage reside in the granule cell layer (GCL) of the DG. The stem and progenitor cells are initially spread throughout the area that will become the GCL, but then coalesce into the SGZ, where they remain into adulthood23,24. We utilized mice expressing a rapidly degrading Kusabira Orange fluorescent protein under the control of a Nestin promoter (Nestin-KOr)41 to identify stem and progenitor cells by visualization of the complete cell body and process. Identifying cell bodies of Nestin- or GFAP- expressing cells is difficult in non-transgenic mice because the endogenous proteins are restricted to the cellular processes. In these experiments, KOr+ cells include Nestin-expressing radial NSCs and non-radial intermediate progenitor cells44,45. Cells that express cell division marker MCM2 can be proliferating NSCs, intermediate progenitors, or neuroblasts44,46, as well as dividing cells unrelated to the NSC lineage.

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