[Delphi 2016 Diagnostic Torrent
Addison Mauldin
Our powerful, feature-packed and easy-to-use DS diagnostic solution gives you this capability and more. Just connect the VCI to the diagnostic socket in the vehicle and it will communicate via Bluetooth, with either the car or heavy duty software installed on your device, giving you instant access to OE-level diagnostics and technical information. All you need to do is choose which software and hardware you want.
Dr. Velculescu is internationally known for his discoveries in genomics and cancer research. He and his colleagues performed the first genome-wide sequence analysis in human cancers, identifying key genes and pathways dysregulated in tumorigenesis.
Dr. Dracopoli brings more than 20 years of biotech and pharma experience to Delfi Diagnostics after having leadership roles at PGDx, Janssen, and Bristol-Myers Squibb in oncology translational science.
Allison joins Delfi with 12 years of experience developing complex algorithms for genetic testing. She has developed and launched laboratory-developed tests in clinical applications including noninvasive prenatal testing, transplanted organ health, and oncology minimal residual disease testing, leading to more than 2 million reported test results.
Nicholas brings more than 20 years of biotech and pharma experience to Delfi Diagnostics after having leadership roles at PGDx, Janssen, and Bristol-Myers Squibb in oncology translational science. Nic obtained his BSc and PhD degrees from the University of London and completed postdoctoral fellowships at the Memorial Sloan-Kettering Cancer Center and Massachusetts Institute of Technology. Subsequently, he served as Assistant Director at the Whitehead Institute/MIT Genome Center, and as a Section Chief at the National Center for Human Genome Research at the National Institutes of Health before moving to the biotechnology and pharmaceutical industry. Nic has authored more than 75 scientific publications and has extensive experience in the fields of genomics, molecular biology, and cancer research.
Lee-Ann most recently served as Associate General Counsel at Twist Bioscience, handling intellectual property, commercial, marketing and procurement legal matters. Prior to that, she specialized in patent preparation, prosecution, and strategy in the biotech, biopharma, medical device, computer and chemical fields as a patent attorney at Sheppard, Mullin, Richeter & Hampton LLP and at Zilka-Kotab, PC. She earned her Ph.D. from the University of Southern California and her J.D. from the Santa Clara University School of Law.
Before joining Delfi, Ally led recruiting and managed HR Business Partnering at 23andMe. After kicking off her career in the nonprofit sector as a health educator, Ally moved into the tech and biotech industries at companies like Netflix and Coherus BioSciences.
Chris has almost 3 decades of healthcare experience spanning diagnostics, large biotech/pharma, and healthcare consulting. His expertise includes commercial strategy and product development, commercial model innovation, and coverage & reimbursement.
Prior to joining Delfi, Chris spent 10 years in molecular diagnostics with Myriad Genetics, Inc. and Veracyte, Inc. where he led cross functional teams on clinical utility evidence generation leading to first in class coverage of novel tests, new coverage for follow-on tests, and expanded coverage of existing tests yielding over $3.0B of increased reimbursable addressable market.
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Rationale: Current diagnosis of chronic hypersensitivity pneumonitis (cHP) involves considering a combination of clinical, radiological, and pathological information in multidisciplinary team discussions. However, this approach is highly variable with poor agreement between centers.
Measurements and main results: Consensus was achieved on 18 of the 40 diagnostic items. Among these, experts gave the highest level of importance to the identification of a causative antigen, time relation between exposure and disease, mosaic attenuation on chest imaging, and poorly formed non-necrotizing granulomas on pathology. In clinical scenarios, the diagnostic confidence of experts in cHP was heightened by the presence of these diagnostic items.
Since somatic or somatosensory tinnitus (ST) was first described as a subtype of subjective tinnitus, where altered somatosensory afference from the cervical spine or temporomandibular area causes or changes a patient's tinnitus perception, several studies in humans and animals have provided a neurophysiological explanation for this type of tinnitus. Due to a lack of unambiguous clinical tests, many authors and clinicians use their own criteria for diagnosing ST. This resulted in large differences in prevalence figures in different studies and limits the comparison of clinical trials on ST treatment. This study aimed to reach an international consensus on diagnostic criteria for ST among experts, scientists and clinicians using a Delphi survey and face-to-face consensus meeting strategy. Following recommended procedures to gain expert consensus, a two-round Delphi survey was delivered online, followed by an in-person consensus meeting. Experts agreed upon a set of criteria that strongly suggest ST. These criteria comprise items on somatosensory modulation, specific tinnitus characteristics, and symptoms that can accompany the tinnitus. None of these criteria have to be present in every single patient with ST, but in case they are present, they strongly suggest the presence of ST. Because of the international nature of the survey, we expect these criteria to gain wide acceptance in the research field and to serve as a guideline for clinicians across all disciplines. Criteria developed in this consensus paper should now allow further investigation of the extent of somatosensory influence in individual tinnitus patients and tinnitus populations.
Importance: Current practice to diagnose idiopathic orbital inflammation (IOI) is inconsistent, leading to frequent misdiagnosis of other orbital entities, including cancer. By specifying criteria, diagnosis of orbital inflammation will be improved.
Results: Of the 53 experts invited to participate, a multinational panel of 35 (66%) individuals with a mean (SD) years of experience of 31 (11) years were included. Consensus was achieved on 7 of 14 clinical and radiologic items and 5 of 7 pathologic items related to diagnosis of nonmyositic IOI, and 11 of 14 clinical and radiologic items and 1 of 5 pathologic items for myositic IOI. There was agreement among panelists to focus on surgical tissue biopsy results in the diagnosis of nonmyositic IOI and on a trial with systemic corticosteroids in myositic IOI. Panelists agreed that a maximum number of 30 IgG4-positive plasma cells per high-power field in the orbital tissue is compatible with the diagnosis of IOI.
Conclusions and relevance: An international panel of experts endorsed consensus diagnostic criteria of IOI. These criteria define a level of exclusion suggested for diagnosis and include tissue biopsy for lesions not confined to the extraocular muscles. This consensus is a step toward developing guidelines for the management of IOI, which needs to be followed by validation studies of the criteria.
Background: Improved imaging techniques have increased the incidence of subsegmental pulmonary embolism (ssPE). Indirect evidence is suggesting that ssPE may represent a more benign presentation of venous thromboembolism not necessarily requiring anticoagulant treatment. However, correctly diagnosing ssPE is challenging with reported low interobserver agreement, partly due to the lack of widely accepted diagnostic criteria.
Methods: Based on an extensive literature review and expert opinion of a Delphi steering committee, two surveys including statements regarding diagnostic criteria and management options for ssPE were established. These surveys were conducted electronically among two panels, respectively: expert thoracic radiologists and clinical venous thromboembolism specialists. The Delphi method was used to achieve consensus after multiple survey rounds. Consensus was defined as a level of agreement >70%.
We present a core list of informative topics, which professionals, patients, and caregivers agree they should be discussed during the diagnostic process in a memory clinic. The topic list can support professionals and empower patients and caregivers during diagnostic physician-patient consultations.
We designed the ABIDE Delphi study to gain insight in how health care professionals, patients, and caregivers value information about diagnostic tests, test results, diagnosis, and the implications of a diagnosis. Our objective was to identify a core set of informative topics on which health care professionals, patients, and caregivers agree that these should be discussed in physician-patient encounters during the diagnostic process, and identify differences between groups concerning which informative topics they value most.
After round 1, each following round participants received feedback of the answers of the total group during the previous round (for the Delphi study flow chart, see Fig. 1). Participants were only invited for the next round if they had completed the questionnaire during the previous round. Topics on which consensus was reached were removed from the next iteration.
The three panels for the Delphi study consisted of (1) memory clinic professionals (professionals), (2) patients who had visited a memory clinic for their cognitive complaints, and (3) caregivers of memory clinic patients (not necessarily related to the participating patients). Professionals were recruited from the ABIDE project group, through an advertisement in the newsletter of the Dutch Memory Clinic Network and by direct mail, and included neurologists, geriatricians, internist-geriatricians, nurses, (neuro) psychologists, and psychiatrists.
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