Importance: Current therapies for traumatic blood loss focus on hemorrhage control and blood volume replacement. Severe hemorrhagic shock, however, is associated with a state of arginine vasopressin (AVP) deficiency, and supplementation of this hormone may decrease the need for blood products in resuscitation.
Objective: To determine whether low-dose supplementation of AVP in patients with trauma (hereinafter referred to as trauma patients) and with hemorrhagic shock decreases their need for transfused blood products during resuscitation.
Design, setting, and participants: This randomized, double-blind placebo-controlled clinical trial included adult trauma patients (aged 18-65 years) who received at least 6 U of any blood product within 12 hours of injury at a single urban level 1 trauma center from May 1, 2013, through May 31, 2017. Exclusion criteria consisted of prehospital cardiopulmonary resuscitation, emergency department thoracotomy, corticosteroid use, chronic renal insufficiency, coronary artery disease, traumatic brain injury requiring any neurosurgical intervention, pregnancy, prisoner status, or AVP administration before enrollment. Data were analyzed from May 1, 2013, through May 31, 2017, using intention to treat and per protocol.
Main outcomes: The primary outcome was total volume of blood product transfused. Secondary end points included total volume of crystalloid transfused, vasopressor requirements, secondary complications, and 30-day mortality.
Conclusions and relevance: Low-dose AVP during the resuscitation of trauma patients in hemorrhagic shock decreases blood product requirements. Additional research is necessary to determine whether including AVP improves morbidity or mortality.
When a Sim transforms into a Vampire (at Teen onward) the Hunger and Bladder needs are replaced by the 'Thirst' motive, which must be satisfied by feeding. Vampires that get too thirsty may enrage and seek out a nearby Sim to drink some blood. Vampires also have 'Vampire Energy', a bar which runs across the top of the needs panel, which is a resource that can be used for Vampire Powers, sun exposure, and staying awake long hours.
Vampires need Plasma, aka cells that are in blood, in order to satisfy the Thirst need. Low Thirst will not kill a Vampire, so you can be a good Vampire that does not drink blood from others, like Edward from Twilight. Plasma comes from a few sources: Sims, Plasma Fruit, and Plasma Packs. Becoming too thirsty will greatly impact your ability to do anything as a Vampire, the uncomfortable moodlet can be so bad as to be +40, overriding all other emotions. Even at parched it is +3 and quite strong.
Options for feeding are found under the Vampire social menu. Feeding from Sims happens in a couple of different ways. First, you can ask nicely if they'd give you a drink of blood. This requires at least a little friendship with the Sim for the prey to be willing. Secondly, you can use your Vampire powers to compel the Sim and get them to submit, providing Plasma in either small or large amounts. Take a lot and the Sim may collapse. Other Sims around may react negatively to your Sim feeding, which can harm relationships. While you can ask to drink from the Sim repeatedly, use of the Vampire Powers to feed has a two hour cooldown. If you didn't get to feed, you may have to back off for a bit or else schmooze with the Sim and hope they'll reconsider. In some situations, I'd recommend they ask then feed aggressively if they decline.
Now that the turn is complete, Nikita's need meters get slightly changed. Take a look at the screenshot to the right. Other than the color change, they're all the same except that the Hunger meter has changed to a Thirst meter. Vampires can eat food, but doing so doesn't help them. Their only source of nutrients is blood, but they can get it several ways.
The most extreme way to get blood is to drink it from another Sim, and there are two ways you can do this. First, Nikita could simply use a "Drink" social command against any other non-vampire adult, which is a positive social interaction. However, despite it being a positive one, the target will decline if they're not at least somewhat friends with her. After all, any Sim who donates their blood in that way receives a "Weakened" buff for 24 hours. (Yes, strangely, it's a buff, not a debuff.) While a Sim is under effects of Weakened, he can't donate blood again. This means that Nikita could sip blood from Saint, but only once per day, which wouldn't be enough to sustain her.
Nikita has a plan. It may take a while, but now that she's a vampire, she's got time on her side. Once Saint manages to climb his way to the top of the film career track, they'll finally move across town in a house, and they'll be ready for children. The problem is that vampires and children don't mix. Not because of the whole blood-drinking thing, but because kids need to be dealt with at inconvenient times.
do you think you could ever modify the pregnancy buff to act as a stuffed buff that lasts temporaory based on how much your sim eats? 3 stages Stuffed, overstuffed, and bursting for the three pregnancy stages. Or maybe it could work like the vore mod does with kirax belly slider. Just wondering because I have no clue on how to mod sims 4.
Plasma is a nutrient-rich component of blood, including Sim blood. It is used by vampires in The Sims 3: Late Night and The Sims 4: Vampires to satisfy their thirst motive, which they have instead of hunger.
In the end, the women were able to consume more oxygen at any given heart rate than they could before the blood draw/exercise training (though it was only statistically significant at higher heart rates). The main finding was that their left ventricle, which is the chamber of the heart responsible for pumping oxygenated blood to tissues throughout the body, remodeled and its function improved.
I would have liked to see three groups: a control group that just carried on with their usual activity; a second group that did the HIIT training only, and a third group that did the blood donation and HIIT training. Then we would have more insight into fitness adaptations for post-menopausal women from this study.
The best type of HIIT training for menopausal women is the type used in the blood-draw/training study, very short (30 seconds max) all out efforts with short recovery. Tabatas are a classic HIIT method of this type. (To do them: Warm-up, push as hard as possible for 20 seconds. Recover for 10 seconds. Repeat 6 to 8 times. Rest 5 minutes, and work up to repeating 2 to 3 more rounds.
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Plasma is a nutrient often found in blood that vampire Sims require in order to thrive. Without plasma, a vampire can become incredibly irritable and lash out, possibly even attacking and feeding off a nearby Sim. Plasma can also be harvested from Plasma Fruit trees, and Sims with a high enough vampire lore skill can create plasma packs from frogs or fish.
Way back, Nummyz did a sequel to her very first game: My Cup of Tea. Cup of Tea II featured a mystical wood called Twilight Forest, where Canon Love Interest Fantom could be unlocked. His creator, an enchanted body of water called The Pond, grew jealous after the protagonist took Fantom away and infected the world with its fumes. The chemicals turned several people into mindless slaves, but it awakened hidden vampire blood in others.
While repeatedly stabbing Tangie Lynn Sims, her killer cut himself and left his blood drops in an Aurora alley in the fall of 1996. Twenty three years later, the blood helped police and other forensic experts solve the case.
A woman was walking her children to school on the morning of Oct. 24, 1996, when she saw something terrible, one Denver Post article said. The bloody body of a young woman with long blond hair was lying on the ground in an alley in the 1200 block of Iola Street.
Three MS scores were calculated using sum of z scores. First was calculated using standardized z scores for waist circumference, systolic arterial pressure, triglycerides, HDL and glucose regressed for age and gender. In calculation of the second MS score, insulin was used instead of glucose, and in the third MS score, HOMA was used. Triglycerides, insulin and HOMA were transformed using logarithmic transformation in order to obtain normal distribution. Z score for HDL was multiplied by -1. Scores derived from principal component analysis (PCA) were also calculated in several different ways. First PCA derived score was calculated using sum of two factors obtained from the factor analysis of five components, waist circumference, mean blood pressure, triglycerides, HDL and glucose. Instead of glucose, HOMA was used to calculate the second PCA derived score. The score was calculated by summing two factors weighted for the variance explained. Third and fourth PCA derived scores were calculated as first component of previously mentioned factor analyses. Sum of z scores and PCA derived scores were calculated for the whole sample and all scores were calculated for subpopulations of children (
In our sample, according to the cutoff values from the joint definition of MS [1], siMS score was calculated using the following formula (with waist circumference and height calculated in cm, glucose, Tg and HDL in mmol/l and systolic blood pressure (TA) in mmHg):
Reference values of each laboratory, nation or country could be used instead of ones used in the present study. Mean arterial pressure and average arterial pressure were used in first versions of the score, but results were very similar to the results provided by the score calculated using systolic blood pressure, thus systolic blood pressure was used in the final score formula for simplicity purposes. Reference values used in current study are not obligatory for all researchers and can be changed in calculation of siMS and siMS risk scores, in accordance with population or local laboratory reference values.
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