a student is working with me to simulate molecular pathways in the
synapse. At the moment simulation speed is not an issue, but I can see
that it will become one soon. I was wondering if there had been any work
done on generating trajectories from Kappa models using a tau-leap
method in a "network-free" simulation.
I'd always thought that tau-leap and Kappa were mutually incompatible,
but I'm now wondering if it could be done by enumerating the complexes
on the LHS and RHS of each rule that were likely to be reached by the
end of a step, and then treating them as conventional complexes in a
I'd be grateful for any pointers or thoughts, even if those thoughts are
that it's impossible or pointless!
David C Sterratt, Senior Research Associate
Institute for Adaptive and Neural Computation, School of Informatics
University of Edinburgh, 10 Crichton Street, Edinburgh EH8 9AB, Scotland, UK
- tel: +44 131 651 1739
The University of Edinburgh is a charitable body, registered in
Scotland, with registration number SC005336.