Jack,
Short answer: yes, take advantage of this building project and vent from the roof if you can.
Our Makerspace is in the basement of a 3 story building. When we first set up our laser, we vented out a window well in our floor... and the smell would waft up to the classrooms (who didn't mind as much when we were cutting wood but acrylic ...). I even once had the Palo Alto Fire Dept show up once when I was cutting a holiday project right after school had let out before the holidays... the neighbors thought the building was on fire.
We now duct it all the way out the roof.
Also, to be clear, you need an active venting system with a fan to draw the smoke, no matter which route you take. Make sure you make space for and/or anticipate for that equipment was well.
Diego