I'm glad you asked. We don't get many requests on this topic and it is an area which we probably need improvement (in the form of a wiki article).
Currently, I'm using a custom RJ12 to USB COM port emulator cable (I created this myself) with the pin-out already established.
Assuming you have your own Mettler Toledo adapter cables, that would work too.
Some Mettler Toledo scales are USB powered, but we're ironically not using USB for communication (despite the converter) so I needed to also obtain a Mettler Toledo AC adapter.
From a programming perspective, there are a few protocols the scale can operate in. I chose to write our sample to work with the Mettler Toledo specification which deals with their own STX and ETX characters.
If you download 1.8.0, on the far right, type in the port name, (i.e. COM1) and click Open Port, Send Port Command, it should display the weight.
The source code for this functionality is all contained within our sample.html demo outlined here:
The code is pretty self explanatory, but it shows how to open the port, send the data, and receive the response. I can go into further detail if needed.
Note, our demo page (1.8.7) contains a bug which affects serial support. Version 1.8.9 has a patch to fix this and you would receive that as a premium customer. (1.8.0 works just fine but is incompatible with Chrome 36 and higher).