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Written by Jordan Chussler. Published 10/7/2025.
Pfizer (NYSE: PFE) is no stranger to income investors. The drugmaker, famous for treatments including Lipitor, Viagra, and Zoloft, has increased its dividend for 16 consecutive years. While that falls short of qualifying it as a Dividend Aristocrat, its current yield of 6.29%—or $1.72 per share annually—has helped PFE earn a place in many portfolios.
However, in terms of share appreciation Pfizer has lost some appeal. After reaching its all-time high (ATH) on Dec. 17, 2021—driven by demand for its COVID-19 vaccine, Comirnaty—the stock has declined by nearly 47% from that peak.
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Invest now and get up to a 30% bonus on shares!This year has been little different. Healthcare stocks overall are having a lackluster year, ranking eighth among the S&P 500’s 11 sectors with a 5.27% year-to-date (YTD) gain. Pfizer, for its part, had been dragging the sector down; before last week, the Big Pharma staple was down more than 11% in 2025.
But after a major announcement by the Trump administration, PFE shares surged in the last week of September, climbing nearly 16% on news that the company reached a landmark agreement with the U.S. government to lower drug costs for American patients.
That rally brought Pfizer out of the red for the year, leaving the pharmaceutical firm with a YTD gain of 2.86%. But are the plans behind TrumpRx enough to keep it in the green? And if so, does that make PFE a buy? Here’s what you need to know.
In response to a letter issued by President Trump in July, Pfizer voluntarily agreed to “implement measures designed to ensure Americans receive comparable drug prices to those available in other developing countries,” according to the company’s press release.
The agreement is intended to provide investors with some “certainty from tariffs” in a year marked by uncertainty. It also lays out clearer pricing frameworks and expanded investment that, over a three-year transition period, is meant to help Pfizer better align U.S. prices with global markets.
The company said it will invest $70 billion in U.S. research and development (R&D) and capital projects (for example, manufacturing) over the next few years to support those goals. While the announcement was a short-term catalyst for PFE shares, questions remain. Experts warn the deal will likely reduce the company’s top line, and with roughly 25% of pharmaceutical industry revenue typically allocated to R&D, large drugmakers could face challenges funding research with reduced revenue.
The agreement accompanies the administration’s rollout of TrumpRx—a website structured similarly to Mark Cuban’s CostPlus Drugs that aims to facilitate direct-to-consumer (D2C) sales. TrumpRx.gov is expected to launch sometime in 2026, and Pfizer is expected to be a major supplier on the exchange, marketing certain drugs for D2C sale at an anticipated 50% discount.
With potentially narrower margins ahead, Pfizer’s financial picture—both past and present—helps put the implications for shareholders into context.
The drugmaker has produced eight consecutive quarterly earnings beats. The last time Pfizer missed both earnings and revenue estimates was Q3 2023. While the streak of beats has been a positive for investors, the company’s underlying fundamentals show mixed signals.
When shares hit their ATH in 2021, Pfizer posted net income of $21.9 billion. That rose to $31.4 billion in 2022, then fell sharply to $2.1 billion in 2023. Last year, net income recovered to about $8 billion, and on a trailing 12-month basis it stands at $10.7 billion.
This recovery suggests Pfizer is finding ways to generate profit even as demand for its COVID-19 vaccines has weakened. However, last year’s net income still represents a decline of more than 74% from 2022.
Cash flow presents another concern: net cash flow was negative $1.8 billion last year, and the company reported negative cash flow of $582 million in Q2. Total liabilities rose nearly 18% between 2021 and 2024 while net assets declined about 17% over the same period.
At the same time, Pfizer carries a relatively high dividend payout ratio of 91.49%, which could limit the likelihood of future increases. The stock carries a consensus Hold rating and a 12-month average price target that implies less than 4% potential upside.