Duplicate Entry Found in JASPAR CORE PFMs: MA2255.1 (Max) and MA2215.1 (dm)

[Xuefen Xu]

Dear JASPAR Team,

Hope you're doing well!

First of all, thank you so much for maintaining such an amazing database - it's been incredibly helpful for my research.

I'm writing to report a small issue I noticed while working with the JASPAR CORE PFMs (the non-redundant text file version). It looks like there might be a duplicate entry in the database.

I found that these two transcription factors have exactly the same PWM matrix:

• MA2255.1 (Max)

• MA2215.1 (dm)

Here's what the data looks like in the file:

>MA2255.1 Max
A  [   541      0      0   1000      0      0      0      0 ]
C  [   208    833   1000      0    958      0      0      0 ]
G  [    41    125      0      0      0   1000      0   1000 ]
T  [   208     41      0      0     41      0   1000      0 ]

>MA2215.1 dm
A  [   541      0      0   1000      0      0      0      0 ]
C  [   208    833   1000      0    958      0      0      0 ]
G  [    41    125      0      0      0   1000      0   1000 ]
T  [   208     41      0      0     41      0   1000      0 ]

As you can see, the numbers are identical for both entries. This caused some confusion in my analysis since I was expecting each TF to have its own unique binding pattern.

Could you please take a look when you have time? Maybe it's just a simple copy-paste error in the database.

Thanks again for all your great work! The database is really wonderful.

Best regards,

Xuefen

[Anthony Mathelier]

Thanks for raising this. These profiles directly come from CISBP, which got them from FlyFactorSurvey. I agree it is weird that the profiles are exactly the same but I do not know how to fix this as it is coming directly from these databases and these profile make sense with respect to the corresponding TFs.