Mario Campli ha scritto:
> Non credo che la buccia del limone possa sciogliere i calcoli biliari,
La buccia di limone no, ma il limonene in essa contenuto fu testato
in Giappone nei primi anni '90 come alternativa atossica al MTBE
per sciogliere i calcoli biliari:
http://www.ncbi.nlm.nih.gov/pubmed/1988264 (1991)
Medical dissolution of gallstones. Clinical experience of d-limonene
as a simple, safe, and effective solvent.
Retained gallstones in the bile ducts account for 60-70% of all
the cases of postcholecystectomy syndromes. A solvent d-limonene
preparation was injected directly to the biliary system of 200
patients to dissolve or disintegrate the retained gallstones.
The outcomes were: retained stones completely disappeared in 96 cases
(48%); partial dissolution in 29 (14.5%); chelating agent was also
used with partial dissolution in 16 (8%); ineffective in 59 (24.5%).
To make this method more effective, several guidelines should be
observed including an in vitro trial dissolution test. Cautious
observation for possible side effects and frequent hepatic and
pancreatic function tests during the treatment with this preparation
also should be performed.
E si trovᅵ che il limonene era molto efficace in miscela con 30-40%
di un monogliceride a catena media:
http://www.ncbi.nlm.nih.gov/pubmed/1526435 (1992)
A useful cholesterol solvent for medical dissolution of gallstones.
Dissolution of cholesterol gallstones by direct instillation of
an agent into the biliary tract has been considered an alternate
to surgical procedures. We developed an excellent direct solubilizer
by combining d-limonene and medium-chain monoglyceride. This mixture
enhances the advantages of each individual solvent and minimizes
the disadvantages. In vitro experiments were done to determine
the viscosities and the cholesterol dissolving rates of various
combinations, and in vivo experiments were conducted to study
their irritation effects on tissues. The optimal combination
was a 3:2 mixture of d-limonene and medium-chain monoglyceride.
It could quickly dissolve cholesterol gallstones with minimal
or no observable side effect.
http://www.ncbi.nlm.nih.gov/pubmed/8366597 (1993)
[Direct gallstone dissolution therapy with GS-100].
[Article in Japanese]
We have developed GS-100, a new direct dissolving drug with strong
dissolution property for cholesterol stone by supplementing
d-limonene, a dissolvent used since 1974, with 30% medium-chain
monoglyceride (MCM). The new drug was applied in 23 patients with
gallbladder stones and three with bile duct stone. The presumptive
analysis of the composition of the stones was drawn from the CT
recordings. As non-invasive therapies, methyl tert-butyl ether (MTBE)
dissolution and extracorporeal shock wave lithotripsy (ESWL), which
are commonly used in Europe and America, have been reported as being
favourable; however, GS-100 is superior in respect to safety and
applicative dimension, suggesting of the possibility of using GS-100
as an important drug in the non-invasive therapy for gallstone
in the near future.
Bye,
*GB*