"IgnazioGSS�" ha scritto:
> Ma anche per quanto riguarda la prevenzione, e' tutto da dimostrare.
Ti vedo molto sul lato scettico, se non addirittura ostile, e alcuni
ritengono che dipenda da una tua simpatia per i farmaci brevettati.
Io invece spero che dipenda da una tua antipatia verso la mancanza di
scrupoli dei dibelliani, oltre al fatto che hai l'artrite reumatoide.
Comunque ecco una review e uno studio molto recenti:
http://www.ncbi.nlm.nih.gov/pubmed/22500582 (2012)
Melatonin uses in oncology: breast cancer prevention and reduction
of the side effects of chemotherapy and radiation.
INTRODUCTION: The possible oncostatic properties of melatonin
on different types of neoplasias have been studied especially in
hormone-dependent adenocarcinomas. Despite the promising results
of these experimental investigations, the use of melatonin
in breast cancer treatment in humans is still uncommon.
AREAS COVERED: This article reviews the usefulness of this indoleamine
for specific aspects of breast cancer management, particularly in
reference to melatonin's antiestrogenic and antioxidant properties:
i) treatments oriented to breast cancer prevention, especially
when the risk factors are obesity, steroid hormone treatment or
chronodisruption by exposure to light at night (LAN); ii) treatment
of the side effects associated with chemo- or radiotherapy.
EXPERT OPINION: The clinical utility of melatonin depends on the
appropriate identification of its actions. Because of its SERM
(selective estrogen receptor modulators) and SEEM (selective
estrogen enzyme modulators) properties, and its virtual absence
of contraindications, melatonin could be an excellent adjuvant
with the drugs currently used for breast cancer prevention
(antiestrogens and antiaromatases). The antioxidant actions
also make melatonin a suitable treatment to reduce oxidative stress
associated with chemotherapy, especially with anthracyclines,
and radiotherapy.
Commento: E' strana la riluttanza degli oncologi a impiegare,
sia pure in via sperimentale, la melatonina (che virtualmente
non ha controindicazioni) in associazione con le terapie correnti,
perch� ci sono moltissimi studi che ne provano i vantaggi.
http://www.ncbi.nlm.nih.gov/pubmed/23354312 (2013)
Blockage of melatonin receptors impairs p53-mediated prevention
of DNA damage accumulation.
Melatonin has been known to be a chemopreventive agent, since
its levels inversely correlate with the risk of developing cancer.
We have recently shown that melatonin induces p38-dependent
phosphorylation of both p53 and histone H2AX. This is associated
with a p53-mediated increase in repair of both endogenous and
chemotherapy-induced DNA damage. In addition, the inhibition of p38
activities impairs melatonin's capability to induce a p53-dependent
DNA damage response and thus its ability to maintain genome integrity.
Since melatonin-induced p53 phosphorylation requires an intact p38
phosphorylation cascade and p38 can be activated by G-proteins,
we supposed that melatonin's activities could be mediated by its
G-proteins coupled membrane receptors, MT1 and MT2. Here, we show
that the activation of the p53-dependent DNA damage response by
melatonin is indeed mediated by MT1 and MT2. As a result, the absence
of either receptor impairs melatonin's ability to reduce both cell
proliferation and clonogenic potential of cancer cells. In addition,
this causes an impairment of the p53-dependent DNA damage response.
By providing molecular insight, our findings might have translational
impact, suggesting the involvement of melatonin receptors in
tumorigenesis.
Commento: Se le cellule tumorali si sbarazzano dei recettori MT1 e MT2,
la melatonina non gli fa pi� niente. Ci� prova che la pretesa di Di Bella
di curare il 99% dei tumori maligni era folle.
Bye,
*GB*