Ciao Marco, ti riporto questa osservazione presentata all'ICAAC del 99, non
ho ancora avuto modo di verificarla perchè normalmente la diarrea nelle
persone che seguo si è risolta in poco tempo senza ricorrere a nessun
farmaco. Puoi provare con bustine di Calcium Sandoz Fortissimum, 1 bustina
al giorno alla modica cifra di 17.100 lire al mese.
Calcium supplements for nelfinavir related diarrhoea
Deirdre Maclean, senior writer, CATIE
The most common and probably most annoying side effect of nelfinavir is
diarrhoea. In a small study involving 24 patients, calcium supplements
reduced nelfinavir-induced diarrhoea in as little as 48 hours.
Before taking part in this study, 50 per cent of the patients reported their
diarrhoea as mild (grade 1, one to three loose stools per day), 42 per cent
described it as moderate (grade 2, three to seven loose stools per day), and
eight per cent rated it as severe (grade 3, more than seven loose stools per
day). All patients had been taking at least one anti-diarrhoea drug.
The subjects were given 500 mg of calcium twice a day and were asked to
report any changes in bowel activity after a minimum of 48 hours. All 24
patients reported improvement, with 16 ( 67 per cent) reporting normal
stools and eight (33 per cent) mild diarrhoea.
These results suggest that calcium tablets, which are relatively cheap and
non-toxic, may be a useful way to relieve nelfinavir-induced diarrhoea.
Ref: Perez-Rodriguez E et al. The role of calcium supplements in the
treatment of nelfinavir-induced diarrhoea. 39th ICAAC; September 26-29,
1999; San Francisco, CA. Abstract 1308. Source: Community AIDS Treatment
Information Exchange (CATIE). For more information visit CATIE's Information
Network at http://www.catie.ca