HEALTH & SCIENCE REPORT: Multiple Topics
The following articles are from multiple resources:
BRAIN
1) Scientists identify a brain signal that reveals whether depression therapies will work
https://www.psypost.org/scientists-identify-a-brain-signal-that-reveals-whether-depression-therapies-will-work/
2) Transcranial magnetic stimulation can target a deep brain region without surgery or medication
https://medicalxpress.com/news/2026-04-transcranial-magnetic-deep-brain-region.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
and
Study finds brain stimulation improves PTSD symptoms by calming fear center
https://medicalxpress.com/news/2026-04-brain-ptsd-symptoms-calming-center.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#goog_rewarded
3) Different types of childhood maltreatment appear to uniquely shape human brain development
https://www.psypost.org/different-types-of-childhood-maltreatment-appear-to-uniquely-shape-human-brain-development/
4) Brain scans shed light on how short videos impair memory and alter neural pathways
https://www.psypost.org/brain-scans-reveal-how-short-videos-impair-memory-and-disrupt-neural-pathways/
5) How the gut-brain connection influences mood
https://www.health.harvard.edu/digestive-health/how-the-gut-brain-connection-influences-mood?utm_source=delivra&utm_medium=email&utm_campaign=WR20260403-SensitiveGut-Shoulders-Alzhemiers&utm_id=10540452&dlv-emuid=3ab216ed-b3ed-41ab-9bc1-9768fc353a48&dlv-mlid=10540452
6) Setting standards of care for brain injuries in first responders
https://medicalxpress.com/news/2026-04-standards-brain-injuries.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
7) Does This Child Have a Concussion? - The Rational Clinical Examination Systematic Review
https://jamanetwork.com/journals/jama/fullarticle/2847281?guestAccessKey=8f064be0-20ba-40a1-a0ae-99d3758c571c&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=olf-tfl_&utm_term=040626
8) Scientists discover intriguing brainwave patterns linked to rhythmic sound meditation
https://www.psypost.org/scientists-discover-intriguing-brainwave-patterns-linked-to-rhythmic-sound-meditation/
9) Why some neuroscientists now believe we have up to 33 senses
https://www.psypost.org/why-some-neuroscientists-now-believe-we-have-up-to-33-senses/
10) Sports Injuries May Cause Long-Term Damage to the Blood-Brain Barrier
https://jamanetwork.com/journals/jama/fullarticle/2847795?guestAccessKey=b29cdb1c-4d04-4c7b-bd7b-81a9b08112d3&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=olf-tfl_&utm_term=041026
11) Why Anesthesiologists Love Ketamine (And Why You Should Understand It) — Different doses lead to different effects on the body and the brain
https://www.medpagetoday.com/popmedicine/popmedicine/120730?xid=nl_popmed_2026-04-10&mh=b472702379519ab6c5a3eb368b1e37ec&zdee=gAAAAABm4vkSlHpatgJA9AhGC93ytnmIdH-i7GN6G83LoYaCXzzN3GR13pz08dfUAsGcfRwkA6zRU5qff2DB2Sn7gqSHqv0DW1XSfoM8sHdL5vtF6nsNhwI%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=PopMedicine_041026&utm_term=NL_Gen_Int_PopMedicine_Active
12) New study finds a missing link in how the brain regulates appetite
https://medicalxpress.com/news/2026-04-link-brain-appetite.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
13) Early life stress fundamentally alters alcohol processing in the brain
https://www.psypost.org/how-growing-up-alone-changes-the-brain-s-response-to-alcohol-2026-03-26/
14) Mini-brain model reveals how mild head hits trigger neurodegenerative cascades
https://medicalxpress.com/news/2026-04-mini-brain-reveals-mild-trigger.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
15) People use the same neurons to see and imagine objects, study shows
https://medicalxpress.com/news/2026-04-people-neurons.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
16) Neurologists Alone Can’t Meet the Demand for Brain Health: Scaling Strategies That Work
https://www.medscape.com/viewarticle/neurologists-alone-cant-meet-demand-brain-health-scaling-2026a100087n?ecd=WNL_trdalrt_pos1_260407_etid8249582&uac=528002PJ&impID=8249582
17) New study challenges widespread belief about fish oil's effects on brain
https://medicalxpress.com/news/2026-04-widespread-belief-fish-oil-effects.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
18) Meditation changes brain activity quickly with a noticeable peak at 7 minutes, research reveals
https://medicalxpress.com/news/2026-04-meditation-brain-quickly-peak-minutes.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
19) Study links childhood brain injury to lasting mental, physical health challenges
https://ntk-institute.org/article/study-links-childhood-brain-injury-to-lasting-mental-physical-health-challenges
20) A child's headache, dizziness and mental fog now stand out as the clearest concussion red flags
https://medicalxpress.com/news/2026-04-child-headache-dizziness-mental-fog.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
21) Blast exposure linked to brain aneurysms in U.S. Special Operations Forces
https://medicalxpress.com/news/2026-04-blast-exposure-linked-brain-aneurysms.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
22) The Fascinating Phenomenon That Is Your Brain on Exercise
https://www.medscape.com/viewarticle/fascinating-phenomenon-your-brain-exercise-2026a1000bqz?ecd=WNL_trdalrt_pos1_260415_etid8269388&uac=528002PJ&impID=8269388
23) Scientists uncover brain circuits for impulsivity
https://medicalxpress.com/news/2026-04-scientists-uncover-brain-circuits-impulsivity.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
24) Pain and creativity share the same brain machinery, unlocking a bold new path to healing
https://medicalxpress.com/news/2026-04-pain-creativity-brain-machinery-bold.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
25) The link between migraine genetics and post-concussion headaches in kids
https://medicalxpress.com/news/2026-04-link-migraine-genetics-concussion-headaches.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
26) E-bike and scooter crashes driving more brain injuries
https://medicalxpress.com/news/2026-04-bike-scooter-brain-injuries.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
27) This Mediterranean‑style diet is linked to a slower loss of brain volume as we age
https://www.psypost.org/this-mediterranean-style-diet-is-linked-to-a-slower-loss-of-brain-volume-as-we-age/
28) Reduced gray matter and altered brain connectivity are linked to problematic smartphone use
https://www.psypost.org/reduced-gray-matter-and-altered-brain-connectivity-are-linked-to-problematic-smartphone-use/
29) Advanced meditation techniques linked to younger brain age during sleep
https://www.psypost.org/advanced-meditation-techniques-linked-to-younger-brain-age-during-sleep/
30) Family Resilience and Mental and Physical Health Sequelae of Pediatric TBI in Youths
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847671?guestAccessKey=2953778d-852a-4a26-b808-60af6b9999a3&utm_term=041326&utm_campaign=ftm_links&utm_medium=referral&_hsenc=p2ANqtz-__FzoSm7EP51iNNg4osmm-WKI9GtZi4ZwthUm5XoeWiCKgVw5A2HvWUGGGZgKweOwmOBa3HHW0M6a3uLqEph-seDaUyBdrrwJ0-OE94tHvp8grWC0&_hsmi=413602546&utm_content=tfl&utm_source=for_the_media
31) The brain's default mode network splits into 'sender' and 'receiver' zones, study finds
https://medicalxpress.com/news/2026-04-brain-default-mode-network-sender.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
32) Impact of traumatic brain injury in children extends beyond initial injury, study demonstrates
https://medicalxpress.com/news/2026-04-impact-traumatic-brain-injury-children.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
ALZHEIMER’S / DEMENTIA
1) How stimulating the vagus nerve could protect the brain from Alzheimer’s disease
https://www.psypost.org/how-stimulating-the-vagus-nerve-could-protect-the-brain-from-alzheimers-disease/
2) The four types of dementia most people don’t know exist
https://www.psypost.org/the-four-types-of-dementia-most-people-dont-know-exist/
3) Midlife Vitamin D Levels Tied to Alzheimer's-Related Brain Changes
— Vitamin D may be a potentially modifiable factor to reduce dementia risk, study suggests
https://www.medpagetoday.com/neurology/alzheimersdisease/120605?utm_source=Sailthru&utm_medium=email&utm_campaign=Automated%20Specialty%20Update%20Neurology%20BiWeekly%20FRIDAY%202026-04-03&utm_term=NL_Spec_Neurology_Update_Active
4) Dementia Risk Tied to Quality of Plant-Based Diets — Simply eating more vegetarian foods may not be enough, study suggests
https://www.medpagetoday.com/neurology/dementia/120724?xid=nl_mpt_DHE_2026-04-09&mh=b472702379519ab6c5a3eb368b1e37ec&zdee=gAAAAABm4vkSlHpatgJA9AhGC93ytnmIdH-i7GN6G83LoYaCXzzN3GR13pz08dfUAsGcfRwkA6zRU5qff2DB2Sn7gqSHqv0DW1XSfoM8sHdL5vtF6nsNhwI%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Evening%20-%20Randomized%202026-04-09&utm_term=NL_Daily_DHE_dual-gmail-definition
5) Tau seeds spread through connected neurons in people with Alzheimer's disease, new research shows
https://medicalxpress.com/news/2026-04-tau-seeds-neurons-people-alzheimer.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
6) Somatostatin in brain regulates immune cells to mitigate dementia, opening path for treatment with existing drugs
https://medicalxpress.com/news/2026-04-somatostatin-brain-immune-cells-mitigate.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
7) Dementia Risk May Be Linked to One's Outlook, Study Suggests — Results persisted after adjusting for depression and major health conditions
https://www.medpagetoday.com/neurology/dementia/120686?xid=nl_mpt_morningbreak2026-04-08&mh=b472702379519ab6c5a3eb368b1e37ec&zdee=gAAAAABm4vkSlHpatgJA9AhGC93ytnmIdH-i7GN6G83LoYaCXzzN3GR13pz08dfUAsGcfRwkA6zRU5qff2DB2Sn7gqSHqv0DW1XSfoM8sHdL5vtF6nsNhwI%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=MorningBreak_040826&utm_term=NL_Gen_Int_Daily_News_Update_active
8) CBD found to reverse brain damage in mouse model of Alzheimer's disease
https://medicalxpress.com/news/2026-04-cbd-reverse-brain-mouse-alzheimer.html?utm_source=nwletter&utm_medium=email&utm_campaign=weekly-nwletter
9) Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.71190
GENERAL & MENTAL HEALTH
1) Cross-Sectional and Longitudinal Relations Among Irritability, Attention-Deficit/Hyperactivity Disorder Symptoms, and Inhibitory Control
https://dgme.docguide.com/article/cross-sectional-and-longitudinal-relations-among-irritability-attention-deficit-hyperactivity-disorder-symptoms-and-inhibitory-control-1
2) Genetic study unravels the link between caffeine intake and sleep timing
https://www.psypost.org/coffee-habits-boost-daytime-alertness-without-inherently-ruining-nighttime-sleep-2026-03-26/
3) Anxious young adults are more likely to develop digital addictions
https://www.psypost.org/how-social-anxiety-and-screen-time-comparison-fuel-digital-addiction-2026-03-26/
4) The psychological divide between Democrats and Republicans during democratic backsliding - People’s happiness and life satisfaction are closely tied to how much they agree with their government’s actions.
https://www.psypost.org/the-psychological-divide-between-democrats-and-republicans-during-democratic-backsliding/
5) Extensive Screen Time May Be an Independent CV Risk Factor for Young Adults
https://www.medscape.com/viewarticle/extensive-screen-time-may-be-independent-cv-risk-factor-2026a10009db?ecd=mkm_ret_260411_mscpmrk_cardio_latest-news_etid8255916&uac=528002PJ&impID=8255916
6) Sleep patterns may reveal hidden heart risks
https://medicalxpress.com/news/2026-04-patterns-reveal-hidden-heart.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
7) Autism associated with age of maternal grandparents in new study
https://www.psypost.org/tracing-the-origins-of-autism-back-to-a-grandmother-s-pregnancy-2026-03-26/
8) Study of 633,000 people links loneliness to suicidal thoughts
https://medicalxpress.com/news/2026-04-people-links-loneliness-suicidal-thoughts.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
9) AI model links mental health to type 2 diabetes
https://medicalxpress.com/news/2026-04-ai-links-mental-health-diabetes.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
10) How Gut Bacteria Could Trigger Memory Loss as We Age
https://www.medscape.com/viewarticle/how-gut-bacteria-could-trigger-memory-loss-we-age-2026a1000a6n?ecd=wnl_sci_tech_260408_MSCPEDIT_etid8250478&uac=528002PJ&impID=8250478
11) High sugar intake is linked to increased odds of depression and anxiety in new study
https://www.psypost.org/high-sugar-intake-is-linked-to-increased-odds-of-depression-and-anxiety-in-new-study/
12) Mental and physical illnesses go hand in hand. A new genetic study explains why
https://medicalxpress.com/news/2026-04-mental-physical-illnesses-genetic.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
13) Disrupted sleep is the primary pathway linking problematic social media use to reduced wellbeing
https://www.psypost.org/disrupted-sleep-is-the-primary-pathway-linking-problematic-social-media-use-to-reduced-wellbeing/
14) Waking at 3 am every night? Here's what may be going on
https://medicalxpress.com/news/2026-04-night.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
15) Can red light therapy really deliver a beauty and health glow-up? Here's the science
https://www.npr.org/2026/04/13/nx-s1-5759287/red-light-therapy-science-skin-hair
16) Making music to treat symptoms of psychosis
https://medicalxpress.com/news/2026-04-music-symptoms-psychosis.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
17) More time spent on social media is linked to a thinner cerebral cortex in young adolescents
https://www.psypost.org/more-time-spent-on-social-media-is-linked-to-a-thinner-cerebral-cortex-in-young-adolescents/
SARS-CoV-2
1) Long COVID is associated with increased risk of cardiovascular disease
https://medicalxpress.com/news/2026-04-covid-cardiovascular-disease.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
2) Concerning COVID Variant Shows Up in 29 States — Despite BA.3.2's spread, XFG variants remain the overwhelming threat in 2025-2026 season
https://www.medpagetoday.com/infectiousdisease/covid19/120519?xid=nl_mpt_InfectiousDisease_update_2026-04-01&mh=b472702379519ab6c5a3eb368b1e37ec&zdee=gAAAAABm4vkSlHpatgJA9AhGC93ytnmIdH-i7GN6G83LoYaCXzzN3GR13pz08dfUAsGcfRwkA6zRU5qff2DB2Sn7gqSHqv0DW1XSfoM8sHdL5vtF6nsNhwI%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=Automated%20Specialty%20Infectious%20Diseases%20%202026-04-01&utm_term=NL_Spec_Infectious_Disease_Update_Active
3) Long COVID Prevalence Decreases as Recovery Rates Improve
https://jamanetwork.com/journals/jama/fullarticle/2846856?guestAccessKey=cb6710c2-e53d-412c-bd6d-cc11680940b7&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=etoc-tfl_&utm_term=041426#google_vignette
YOUTH
1) How unsupervised screen time harms vulnerable preschoolers
https://medicalxpress.com/news/2026-04-unsupervised-screen-vulnerable-preschoolers.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
2) Insufficient Sleep Among US Adolescents Across Behavioral Risk Groups
https://jamanetwork.com/journals/jama/fullarticle/2845759?guestAccessKey=147743e3-a31d-4fcb-988d-8e184d217644&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=etoc-tfl_&utm_term=040726
3) Stacking bad habits triples the risk of co-occurring anxiety and depression in teenagers
https://www.psypost.org/stacking-bad-habits-triples-the-risk-of-co-occurring-anxiety-and-depression-in-teenagers/
4)
THC CBD PSYCHEDELICS
1) Cannabis intoxication broadly impairs multiple memory types, new study shows
https://www.psypost.org/cannabis-intoxication-broadly-impairs-multiple-memory-types-new-study-shows/
2) Psilocybin Failed to Live Up to Hype for Treatment-Resistant Depression — Researchers questioned psychedelic's true efficacy in unblinded trials
https://www.medpagetoday.com/psychiatry/depression/120375?xid=nl_mpt_Psychiatry_update_2026-03-25&mh=b472702379519ab6c5a3eb368b1e37ec&zdee=gAAAAABm4vkSlHpatgJA9AhGC93ytnmIdH-i7GN6G83LoYaCXzzN3GR13pz08dfUAsGcfRwkA6zRU5qff2DB2Sn7gqSHqv0DW1XSfoM8sHdL5vtF6nsNhwI%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=Automated%20Specialty%20Update%20Psychiatry%202026-03-25&utm_term=NL_Spec_Psychiatry_Update_Active
3) Psychedelic Eased Symptoms of Treatment-Resistant Depression
— Findings should be interpreted with caution, given the lack of placebo effect, expert says
https://www.medpagetoday.com/psychiatry/depression/120489?xid=nl_mpt_Psychiatry_update_2026-03-25&mh=b472702379519ab6c5a3eb368b1e37ec&zdee=gAAAAABm4vkSlHpatgJA9AhGC93ytnmIdH-i7GN6G83LoYaCXzzN3GR13pz08dfUAsGcfRwkA6zRU5qff2DB2Sn7gqSHqv0DW1XSfoM8sHdL5vtF6nsNhwI%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=Automated%20Specialty%20Update%20Psychiatry%202026-03-25&utm_term=NL_Spec_Psychiatry_Update_Active
4) This is your brain on psychedelics: Neuroimaging study sheds light on cortical network effects
https://medicalxpress.com/news/2026-04-brain-psychedelics-neuroimaging-cortical-network.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
5) Can a psychedelic journey change what you value most?
https://www.psypost.org/psilocybin-triggers-lasting-changes-in-personal-values-for-healthy-volunteers/
6) CBD found to reverse brain damage in mouse model of Alzheimer's disease
https://medicalxpress.com/news/2026-04-cbd-reverse-brain-mouse-alzheimer.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter#google_vignette
7) Scientists uncover the neurological mechanisms behind cannabis-induced “munchies”
https://www.psypost.org/scientists-uncover-the-neurological-mechanisms-behind-cannabis-induced-munchies/
8) Psychedelic therapy and traditional antidepressants show similar results under open-label conditions
https://www.psypost.org/psychedelic-therapy-and-traditional-antidepressants-show-similar-results-under-open-label-conditions/
9) Low doses of LSD alter emotional brain responses in people with mild depression
https://www.psypost.org/low-doses-of-lsd-alter-emotional-brain-responses-in-people-with-mild-depression/
AI
1) AI May Drive Health Costs Up, Doc-Economist Says — Series poses questions about healthcare costs to top economists and policy experts
https://www.medpagetoday.com/special-reports/features/120480?xid=nl_mpt_DHE_2026-03-25&mh=b472702379519ab6c5a3eb368b1e37ec&zdee=gAAAAABm4vkSlHpatgJA9AhGC93ytnmIdH-i7GN6G83LoYaCXzzN3GR13pz08dfUAsGcfRwkA6zRU5qff2DB2Sn7gqSHqv0DW1XSfoM8sHdL5vtF6nsNhwI%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Evening%20-%20Randomized%202026-03-25&utm_term=NL_Daily_DHE_dual-gmail-definition
2) Americans may be losing trust for AI in health care, survey suggests
https://medicalxpress.com/news/2026-04-americans-ai-health-survey.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
3) AI remains lacking in clinical reasoning abilities, according to study of 21 large language models
https://medicalxpress.com/news/2026-04-ai-lacking-clinical-abilities-large.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
4) Popular AI chatbots are confidently dispensing medical misinformation, analysis shows
https://medicalxpress.com/news/2026-04-popular-ai-chatbots-confidently-medical.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
5) Poll reveals millions of Americans consult AI before, after—and sometimes instead of—seeing a doctor
https://medicalxpress.com/news/2026-04-poll-reveals-millions-americans-ai.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
6) Top AI models fall short on true clinical reasoning despite diagnostic strength
https://ntk-institute.org/article/top-ai-models-fall-short-on-true-clinical-reasoning-despite-diagnostic-strength
7) Can AI Fix the Mental Health Crisis?
https://www.medscape.com/viewarticle/can-ai-fix-mental-health-crisis-2026a1000bcn?ecd=WNL_trdalrt_pos1_260413_etid8263879&uac=528002PJ&impID=8263879
"The ISNR listserv is a platform for professional discussion and the exchange of information relevant to the field of neuroregulation. ISNR does not endorse or support any specific political, ideological, or policy agenda, nor does it take responsibility for the accuracy, opinions, or implications of any content shared by members. Posts reflect the views of individual contributors and not those of ISNR as an organization. While we encourage the sharing of information from reputable sources, members are responsible for critically evaluating all content. ISNR reserves the right to moderate discussions to ensure a respectful and professional exchange of ideas."
END
Be Well, Stay Safe
Rob
CONFIDENTIALITY NOTICE ~ HIPAA Privacy Notification: The information contained in this e-mail message may be privileged, confidential, and/or protected from disclosure. This e-mail message may contain protected health information (PHI); dissemination of PHI should comply with applicable federal and state laws. If you are not the intended recipient, or an authorized representative of the intended recipient, any further review, disclosure, use, dissemination, distribution, or copying of this message or any attachment (or the information contained therein) is strictly prohibited. If you think that you have received this e-mail message in error, please notify the sender by return e-mail and delete all references to it and its contents from your systems.