The IP : 127.0.0.1 which you are referring to is the hardware loopback IP.
Every Hardware irrespective of vendor have its fixed loopback IP globally constant as 127.0.0.1.
lo0: flags=8049<UP,LOOPBACK,RUNNING,MULTICAST> metric 0 mtu 16384
inet6 ::1 prefixlen 128 zone 1
inet6 fe80::1%lo0 prefixlen 64 scopeid 0x5 zone 1
inet 127.0.0.1 netmask 0xff000000 zone 1
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This loopback IP is been used for the internal hardware communication and even also for the local replications too.
The file : /etc/resolv.conf, is similar to the host entry that we have on server and desktop [C:\Windows\System32\drivers\etc].
Isilon OS will created a host entry automatically for the localhost [node] for internal communication within hardware and cluster.
Because of this also you are not getting Host-A entry on AD-DNS on your network through nslookup.
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It seems your problem is not with the IP 127.0.0.1, for me it seems to be routeing issue, number of hopes count is high due to this you may be facing the latency issue.
Please check the trace-route of your Isilon Node IP from your desktop\server and check the hop count at different subnet level.