Ebola
virus disease (EVD) is a complex zoonosis that is highly virulent in
humans. The largest recorded outbreak of EVD is ongoing in West Africa,
outside of its previously reported and predicted niche. We assembled
location data on all recorded zoonotic transmission to humans and Ebola
virus infection in bats and primates (1976-2014). Using species
distribution models, these occurrence data were paired with
environmental covariates to predict a zoonotic transmission niche
covering 22 countries across Central and West Africa. Vegetation,
elevation, temperature, evapotranspiration, and suspected reservoir bat
distributions define this relationship. At-risk areas are inhabited by
22 million people; however, the rarity of human outbreaks emphasises the
very low probability of transmission to humans. Increasing population
sizes and international connectivity by air since the first detection of
EVD in 1976 suggest that the dynamics of human-to-human secondary
transmission in contemporary outbreaks will be very different to those
of the past.