ODBC is not connecting in my localhost itself.

[Navin Kumar G]

Driver = C:\Program Files\Common Files\InterSystems\Cache\CacheODBC35.dll

Driver Version = 2015.1.0.429.0

Data Source Name = CACHE10 User

Host (IP Address) = 127.0.0.1

Port = 56775

Caché Namespace = USER

Authentication Method = 0  - Password

User Name = _system

Description = Cache Configuration and Namespace - CACHE10 USER

Cache ODBC Logging = No

Use Locale Decimal symbol = No

Disable Query Timeout = 0

Static Cursors Support = 0

Unicode SQLTypes = 0

Connect Error: See CacheODBC.log for details

[Cache ODBC][State : HY000][Native Code 417]

[C:\Windows\system32\odbcad32.exe]

Access Denied

[Alexander Koblov]

For "Access Denied" cases it is useful to enable Audit in Caché, enable loggin of LoginFailure event, reproduce the problem and then check Audit log for more details.
http://docs.intersystems.com/latest/csp/docbook/DocBook.UI.Page.cls?KEY=GCAS_audit#GCAS_audit_basics