IGB match wrong coordinate on GRCh37

[Robersy Sanchez]

For some reason that I do not know, IGB (9.1.8) is matching the wrong coordinate on GRCh37. After load WIG files there is shift of 1bp. 

For example:

You can check the track: 'pall_tv_pall_chr1-11.wig' at https://github.com/genomaths/genomaths.github.io/tree/master/ScientificReports_10(1)_2020

1. For coordinate chr9:139563066 (score = -0.60119) an hypomethylated DMP is reported (in the WIG file), which is shown in the IGB at coordinate chr9:139563065.

2.  For coordinate chr9:139563098 (score = -0.45) an hypomethylated DMP is reported, which is  shown in the IGB at coordinate chr9:139563097 

Would you please help me with this small issue?

Best regards,

Robersy

[Nowlan Freese]

Hi Robersy,

Thank you for pointing this out, I will take a look right away and see what I can find. 

Best,

Nowlan

[Nowlan Freese]

I double-checked the file on IGB and UCSC, the locations specified in the wig files are correct relative to the GRCh37 sequence.

The reason that IGB shows the coordinates as one less than expected is because IGB is 0-based, so the first base position of the genome sequence is 0 (instead of 1). This is compared to UCSC (for example) that displays as 1-based.