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Testosterone undecanoate injection (Aveed) may cause serious breathing problems and allergic reactions, during or immediately after the injection. The injection should be given by a doctor or nurse in a healthcare setting where these problems or reactions can be treated. You will need to remain in the healthcare setting for at least 30 minutes after you receive your injection. Tell your doctor or nurse immediately if you experience any of the following symptoms during or after your injection: tightening of your throat, difficulty breathing, difficulty swallowing, shortness of breath, cough or urge to cough, chest pain, dizziness, fainting, sweating, rash, hives, or itching.

A program has been set up to limit the use of testosterone undecanoate injection (Aveed) and to inform people about the increased risk of breathing problems and allergic reactions while receiving this medication. The program also makes sure that everyone who received this medication understands the risks and benefits from this medication and receives the medication in a setting where they can be monitored for serious reactions.

Testosterone enanthate injection (Xyosted) and other testosterone products may cause an increase in blood pressure which can increase your risk of having a heart attack or stroke that may be life-threatening. Tell your doctor if you have or have ever had high blood pressure, heart disease, a heart attack, or a stroke. Tell your doctor and pharmacist if you are taking medications for blood pressure, pain, or cold symptoms. If you experience any of the following symptoms, call your doctor immediately: chest pain; shortness of breath; pain in the arms, back, neck, or jaw; slow or difficult speech; dizziness or faintness; or weakness or numbness of an arm or leg.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with testosterone undecanoate injection or testosterone enanthate injection (Xyosted). Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( ) or the manufacturer's website to obtain the Medication Guide.

Testosterone cypionate (Depo-Testosterone), testosterone enanthate (Xyosted, available generically), testosterone undecanoate (Aveed), and testosterone pellet (Testopel) are forms of testosterone injection used to treat symptoms of low testosterone in men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland (a small gland in the brain), or hypothalamus (a part of the brain) that cause hypogonadism. Your doctor will order certain lab tests to check your testosterone levels to see if they are low before you begin to use testosterone injection. Testosterone enanthate (available generically) and testosterone pellet (Testopel) are also used to stimulate puberty in males with delayed puberty. Testosterone enanthate (available generically) injection may be used in certain women with a type of breast cancer called mammary cancer that has spread to other parts of the body. Testosterone should not be used to treat the symptoms of low testosterone in men who have low testosterone due to aging ('age related hypogonadism'). Testosterone is in a class of medications called androgenic hormones. Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone injection works by supplying synthetic testosterone to replace the testosterone that is normally produced naturally in the body. When used to treat breast cancer, testosterone works by stopping the release of estrogen.

Testosterone cypionate, testosterone enanthate (available generically), and testosterone undecanoate injection come as a solution (liquid) to be injected into a muscle and as a pellet to be injected under the skin by a doctor or nurse in an office setting or clinic. Testosterone enanthate injection (Xyosted) comes as a solution (liquid) to be injected subcutaneously (under the skin) once a week by yourself or a caregiver.

Testosterone injection may control your symptoms but will not cure your condition. Your doctor may adjust your dose of testosterone depending on the amount of testosterone in your blood during your treatment and your reaction to the medication.

Always look at your testosterone enanthate (Xyosted) solution before you inject it. It should be clear to light yellow in color and free of visible particles. Do not use it if it is cloudy, contains visible particles, or if the expiration date on the package has passed.

You can inject testosterone enanthate injection (Xyosted) in the left or right side of your abdomen (stomach) except your navel and the area 2 inches around it. Do not inject into an area where the skin is tender, bruised, red, or hard or where you have scars, tattoos, or stretch marks.

Testosterone injection may cause a decrease in the number of sperm (male reproductive cells) produced, especially if it is used at high doses. Talk to your doctor about the risks of using this medication if you are a man and would like to have children.

Testosterone injection may cause the bones to mature more quickly than normal in children who receive the medication. This means that the children may stop growing sooner than expected and may have a shorter than expected adult height.

Keep testosterone enanthate injection (Xyosted) in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). Do not refrigerate or freeze.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( ) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Do not let anyone else use your testosterone enanthate injection (Xyosted). Testosterone is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Smoking is a hard habit to break because tobacco contains the very addictive chemical nicotine. As with heroin or other addictive drugs, the body and mind quickly get used to the nicotine in cigarettes. Soon, a person needs to have it just to feel normal.

People start smoking for different reasons. Some think it looks cool. Others start because their family members or friends smoke. Almost all adult tobacco users started before they were 18 years old. Most never expected to become addicted. That's why it's so much easier to not start smoking at all.

Some people think that e-cigarettes are safer than regular cigarettes because they don't contain tobacco. But the other ingredients in them are dangerous too. In fact, there are reports of serious lung damage and even death among people who use e-cigarettes. So health experts strongly warn against using them.

Hookahs are water pipes used to smoke tobacco through a hose with a mouthpiece. Some people think they're safer than cigarettes because the smoke cools when it passes through the water. But look at the black gunk that builds up in a hookah hose. Some of that gets into users' mouths and lungs. And since they don't have filters and people often use them for long periods, their health risks might be even greater. Hookahs are usually shared, so there's the added risk from germs being passed around along with the pipe.

Many of the chemicals in cigarettes, like nicotine and cyanide, are poisons that can kill in high doses. The body is smart. It goes on the defense when it's being poisoned. First-time smokers often feel pain or burning in their throat and lungs, and some even throw up the first few times they try tobacco.

Smoking can affect sexual health in both men and women. Girls who smoke and are on hormone-based birth control methods like the Pill, the patch, or the ring have a higher risk of serious health problems, like heart attacks. And if a woman wants to get pregnant, smoking can make that harder.

The only thing that really helps is staying away from all these products. This isn't always easy, especially if everyone around you is smoking or vaping. It may help to have your reasons for saying no ready for times you may feel the pressure. Try "I just don't like it" or "I want to stay in shape for soccer" (or football, basketball, or other sport).

If you do smoke or vape and want to quit, you have lots of information and support available. Different approaches to quitting work for different people. For some, quitting cold turkey is best. Others find that a slower approach is the way to go. Some people find that it helps to go to a support group especially for teens.

Note: All information on Nemours KidsHealth is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor. 1995-2024. The Nemours Foundation. Nemours Children's Health, KidsHealth, and Well Beyond Medicine are registered trademarks of The Nemours Foundation. All rights reserved. Images sourced by The Nemours Foundation and Getty Images.

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