Table of Contents Alert: EMBO reports, Vol. 22, No. 2, 03 February 2021
EMBO reports
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EMBO reports Volume 22, Issue 2 03 February 2021 |
On the cover: HAT1 succinylates histones and non-histones. In this issue of EMBO Reports, Guang Yang, Xiaodong Zhang and colleagues report on the novel tumor promoting succinyltransferase function of HAT1, in addition to its acetyltransferase activity. Cover illustration by SciStories LLC.
Opinion
Free AccessDo scientists read enough fiction?
David R SmithEMBO Rep (2021) 22: e52206 | First Published: 04 January 2021
Reading the academic literature is an essential part of a scientist’s job. David Smith argues that reading fiction can be even more important for creativity and productivity than papers and reviews.
News & Views
Connecting autoimmune disease to Bardet–Biedl syndrome and primary cilia
Tomoharu Kanie, Peter K JacksonEMBO Rep (2021) 22: e52180 | First Published: 28 January 2021
Bardet‐Biedl syndrome is a genetic disorder caused by the dysfunction of the primary cilium. A study in this issue now sheds new light on the potential role of primary cilia in controlling immune function in disease.
Science & Society
A method to the madness : Disentangling the individual forces that shape the rumen microbiome
Itzhak Mizrahi, Elie JamiEMBO Rep (2021) 22: e52269 | First Published: 02 February 2021
The rumen microbiome ‐ a remarkable example of obligatory symbiosis with high ecological and social relevance
Portugal’s prominence in malaria research : How a small country became a key player in European research on one of the world’s deadliest diseases
Miguel PrudêncioEMBO Rep (2021) 22: e51692 | First Published: 10 January 2021
Despite its limited resources, Portugal has gained a prominent position in research on malaria. Several historical and personal factors have contributed to this achievement.
Technical bias and the reproducibility crisis : The problem of systemic errors resulting from artifacts of equipment, methods or dataset has been underappreciated
Philip HunterEMBO Rep (2021) 22: e52327 | First Published: 25 January 2021
Technical bias can cause lack of reproducibility. While harder to identify than other bias, it can cause consistent systemic errors in experimental data and analysis.
Review
Open AccessChromatin accessibility dynamics during cell fate reprogramming
Dongwei Li, Xiaodong Shu, Ping Zhu, Duanqing PeiEMBO Rep (2021) 22: e51644 | First Published: 22 January 2021
This review discusses how chromatin binary on/off switches are linked to cell identity in iPSC reprogramming, with closing and opening loci occupied by somatic and pluripotent transcription factors, respectively.
Reports
Rab11‐FIP1 mediates epithelial‐mesenchymal transition and invasion in esophageal cancer
Qiaosi Tang, Ashley Lento, Kensuke Suzuki, Gizem Efe, Tatiana Karakasheva, Apple Long, Véronique Giroux, Mirazul Islam, E Paul Wileyto, Andres J Klein‐Szanto, Hiroshi Nakagawa, Adam Bass, Anil K RustgiEMBO Rep (2021) 22: e48351 | First Published: 06 January 2021
Loss of the Rab coupling protein Rab11‐FIP1 fosters disruption of epithelial stratification, tumor cell invasion and EMT in esophageal squamous cell carcinoma.
FAM111A induces nuclear dysfunction in disease and viral restriction
Minghua Nie, Martina Oravcová, Yasaman Jami‐Alahmadi, James A Wohlschlegel, Eros Lazzerini‐Denchi, Michael N BoddyEMBO Rep (2021) 22: e50803 | First Published: 28 December 2020
The protease FAM111A was identified as an antiviral restriction factor, and as the gene mutated in two multisystem human syndromes, KCS2 and OCS. Patient mutations and polyomavirus replication in restrictive cells hyperactivate FAM111A, resulting in compromised nuclear barrier function, DNA replication, and cell viability.
Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly
Hugo Wioland, Stéphane Frémont, Bérengère Guichard, Arnaud Echard, Antoine Jégou, Guillaume Romet‐LemonneEMBO Rep (2021) 22: e50965 | First Published: 04 January 2021
The oxidation of actin filaments by MICAL1 triggers their rapid disassembly by cofilin‐1, even when cofilin‐1 is at very low concentration or is inhibited by phosphorylation, and when filaments are protected by Tropomyosin 1.8.
Open AccessGradual centriole maturation associates with the mitotic surveillance pathway in mouse development
Cally Xiao, Marta Grzonka, Charlotte Meyer‐Gerards, Miriam Mack, Rebecca Figge, Hisham BazziEMBO Rep (2021) 22: e51127 | First Published: 07 January 2021
This study shows that the de novo formed centrioles in the early developing mouse gradually mature to participate in mitosis and cilia formation around gastrulation, when the mitotic surveillance pathway is activated.
Articles
Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis
Guang Yang, Ying Yuan, Hongfeng Yuan, Jiapei Wang, Haolin Yun, Yu Geng, Man Zhao, Linhan Li, Yejing Weng, Zixian Liu, Jinyan Feng, Yanan Bu, Lei Liu, Bingnan Wang, Xiaodong ZhangEMBO Rep (2021) 22: e50967 | First Published: 29 December 2020
Histone acetyltransferase 1 is a succinyltransferase for histone H3 and PGAM1, thereby contributing to epigenetic regulation and glycolysis to promote tumor growth.
Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self‐tolerance
Oksana Tsyklauri, Veronika Niederlova, Elizabeth Forsythe, Avishek Prasai, Ales Drobek, Petr Kasparek, Kathryn Sparks, Zdenek Trachtulec, Jan Prochazka, Radislav Sedlacek, Philip Beales, Martina Huranova, Ondrej StepanekEMBO Rep (2021) 22: e50785 | First Published: 11 January 2021
Bardet‐Biedl Syndrome is a pleiotropic genetic disease caused by the dysfunction of primary cilia. BBS is associated with altered hematopoiesis and homeostasis of the immune system in patients and mouse models.
Open AccessUSP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination
Jens Roedig, Lisa Kowald, Thomas Juretschke, Rebekka Karlowitz, Behnaz Ahangarian Abhari, Heiko Roedig, Simone Fulda, Petra Beli, Sjoerd JL van WijkEMBO Rep (2021) 22: e50163 | First Published: 28 December 2020
Ubiquitin‐specific protease 22 (USP22) controls necroptotic cell death by regulating RIPK3 phosphorylation and RIPK3 K518 ubiquitination in human tumor cell lines.
Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet‐Polycomb‐Octβ2R cascade
Zhangwu Zhao, Xianguo Zhao, Tao He, Xiaoyu Wu, Pengfei Lv, Alan J Zhu, Juan DuEMBO Rep (2021) 22: e47910 | First Published: 07 January 2021
An epigenetic regulatory mechanism regulates sleep homeostasis through an octopamine‐responsive Stuxnet‐Pc‐Octβ2R cascade reducing Octβ2R receptor levels, thus avoiding unfavorable effects of octopamine on sleep.
Open AccessEVL regulates VEGF receptor‐2 internalization and signaling in developmental angiogenesis
Joana Zink, Maike Frye, Timo Frömel, Claudia Carlantoni, David John, Danny Schreier, Andreas Weigert, Hebatullah Laban, Gabriela Salinas, Heike Stingl, Lea Günther, Rüdiger Popp, Jiong Hu, Benoit Vanhollebeke, Hannes Schmidt, Amparo Acker‐Palmer, Thomas Renné, Ingrid Fleming, Peter M BenzEMBO Rep (2021) 22: e48961 | First Published: 29 January 2021
This study reveals that the Ena/VASP protein family member EVL is a regulator of endothelial cell proliferation and sprouting in the postnatal retina.
Open AccessCoordinated control of adiposity and growth by anti‐anabolic kinase ERK7
Kiran Hasygar, Onur Deniz, Ying Liu, Josef Gullmets, Riikka Hynynen, Hanna Ruhanen, Krista Kokki, Reijo Käkelä, Ville HietakangasEMBO Rep (2021) 22: e49602 | First Published: 28 December 2020
This study demonstrates that the atypical MAP kinase ERK7 reduces adiposity and inhibits growth of Drosophila larvae. ERK7 acts in the fat body by inhibiting chromatin binding protein PWP1 and transcription factor Sugarbabe.
Open AccessPaladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis
Anja Nitzsche, Riikka Pietilä, Dominic T Love, Chiara Testini, Takeshi Ninchoji, Ross O Smith, Elisabet Ekvärn, Jimmy Larsson, Francis P Roche, Isabel Egaña, Suvi Jauhiainen, Philipp Berger, Lena Claesson‐Welsh, Mats HellströmEMBO Rep (2021) 22: e50218 | First Published: 28 December 2020
This study identifies Paladin as a vascular PI(4,5)P2 phosphatase, which restricts VEGFR2 internalization and activation of downstream signaling, thereby dampening angiogenesis.
Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR
Lang Rao, Indhira De La Rosa, Yi Xu, Youbao Sha, Abhisek Bhattacharya, Michael J Holtzman, Brian E Gilbert, N Tony EissaEMBO Rep (2021) 22: e50613 | First Published: 20 December 2020
Virulence of Pseudomonas aeruginosa depends on its ability to reside and replicate unchallenged inside airway epithelial cells. The type III secretion system effector ExoS enables this bacterial survival by inhibiting autophagy and mTOR.
Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion
Shun Akaeda, Yasushi Hirota, Yamato Fukui, Shizu Aikawa, Ryoko Shimizu‐Hirota, Tetsuaki Kaku, Mona Gebril, Tomoyuki Hirata, Takehiro Hiraoka, Mitsunori Matsuo, Hirofumi Haraguchi, Mayuko Saito‐Kanatani, Norihiko Takeda, Tomoyuki Fujii, Yutaka OsugaEMBO Rep (2021) 22: e50927 | First Published: 05 January 2021
Uterine Rb1‐induced cell cycle arrest is involved in TNFα‐primed epithelial necroptosis at the implantation site, and these processes are critical for embryo invasion. These findings may help to better understand the molecular factors underlying human recurrent implantation failure.
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity
Jia Song, Tongtong Liu, Yue Yin, Wei Zhao, Zhiqiang Lin, Yuxin Yin, Dan Lu, Fuping YouEMBO Rep (2021) 22: e51162 | First Published: 04 January 2021
OTUD1 stabilizes IREB2 and enhances TFRC‐mediated iron uptake in intestinal epithelial cells. OTUD1 increases cell susceptibility to ferroptosis and is essential for T cell surveillance against cancer.
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