Table of Contents Alert: The EMBO Journal, Vol. 40, No. 19, 01 October 2021
The EMBO Journal
If you no longer wish to receive these alerts, unsubscribe here.
 |
 |
The EMBO Journal Volume 40, Issue 19 01 October 2021 |
On the cover: Nanobodies targeting SARS-CoV-2 variants. In this issue of The EMBO Journal, Thomas Güttler, Metin Aksu, Matthias Dobbelstein, Dirk Görlich and colleagues developed single-domain antibodies of camelid (alpaca) origin, dubbed "nanobodies", that potently neutralize SARS-CoV-2 by blocking the Spike's receptor-binding domain (RBD). Image concept by the authors; illustration by SciStories LLC.
Review
Open Access
HighlightAutophagy in major human diseases
EMBO J (2021) 40: e108863 | First Published: 30 August 2021
This review provides an exhaustive overview of the contribution of autophagy to multiple pathological phenotypes in vivo, and discusses the therapeutic potential of autophagy modulation in disease prevention and treatment.
Articles
Open AccessHighlightNeutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies
EMBO J (2021) 40: e107985 | First Published: 24 July 2021
Single-domain camelid antibodies that neutralize a range of common and emerging immune-escape mutant strains of SARS-CoV-2 may constitute an easily-producible option for treatment of COVID-19 patients.
Open AccessIdentification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites
EMBO J (2021) 40: e108375 | First Published: 10 August 2021
The lectin receptors Clec4g and CD209c bind to the glycosylated SARS-CoV-2 Spike protein to interfere with Spike binding to cell surfaces and SARS-CoV-2 infection.
Open AccessMitotic WNT signalling orchestrates neurogenesis in the developing neocortex
EMBO J (2021) 40: e108041 | First Published: 25 August 2021
WNT/STOP (STabilization Of Proteins) signalling is the primary driver of neuronal differentiation of progenitor cells, while WNT/β-catenin signalling predominantly regulates progenitor cell self-renewal.
Open AccessNDST3 deacetylates α‐tubulin and suppresses V‐ATPase assembly and lysosomal acidification
EMBO J (2021) 40: e107204 | First Published: 25 August 2021
NDST3-dependent deacetylation of α-tubulin prevents lysosomal hyperacidification and proteotoxicity associated with C9orf72 hexanucleotide repeat expansion in neurodegenerative disorders.
Open AccessA Brucella effector modulates the Arf6‐Rab8a GTPase cascade to promote intravacuolar replication
EMBO J (2021) 40: e107664 | First Published: 23 August 2021
Brucella abortus effector protein BspF binding to host GTPase-activating protein ACAP1 facilitates intracellular bacterial growth by decreasing retrograde vesicular transport to the trans-Golgi network.
Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross‐linking enzymes in Escherichia coli
EMBO J (2021) 40: e108126 | First Published: 12 August 2021
Peptidoglycan expansion requires a minimum set of dual specificity endopeptidases that hydrolyse both the most abundant D,D-transpeptidase crosslinks, but also alternative crosslinks formed by L,D-transpeptidases.
Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL
EMBO J (2021) 40: e107988 | First Published: 23 August 2021
Replication of human mitochondrial DNA involves transcript slippage and RNA primer handover/protection within a primosome formed by mtRNAP and DNA polymerase PolG.
SNP rs4971059 predisposes to breast carcinogenesis and chemoresistance via TRIM46‐mediated HDAC1 degradation
EMBO J (2021) 40: e107974 | First Published: 30 August 2021
Enhanced tumor cell proliferation upon HDAC1 downregulation, induced by enhanced TRIM46 E3 ligase expression due to a cancer-associated polymorphic switch, exemplifies a tumor-suppressive role of HDAC1 in this context.
Open AccessMsps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells
EMBO J (2021) 40: e104549 | First Published: 09 August 2021
The microtubule regulator Mini Spindles (Msps)/XMAP215 promotes Drosophila neural stem cell activation, by targeting adhesion molecule E-cadherin via Kinesin-2 motors to neural stem cell-neuropil contact sites.
Open AccessMulti‐modal adaptor‐clathrin contacts drive coated vesicle assembly
EMBO J (2021) 40: e108795 | First Published: 06 September 2021
Single particle cryo-EM analysis reveals how Adaptor Protein 2 promotes clathrin assembly during endocytosis by crosslinking clathrin triskelia at different locations in the cage.
Cryo‐EM analysis provides new mechanistic insight into ATP binding to Ca2+‐ATPase SERCA2b
EMBO J (2021) 40: e108482 | First Published: 30 August 2021
Structural analysis shows human SERCA2b ATPase to adopt an unexpectedly compact functional state prior to ATP binding, suggesting a new mechanism of ATP binding to SERCA family members.
Resource
Open AccessHighlightFluc‐EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease
EMBO J (2021) 40: e107260 | First Published: 19 August 2021
In vivo expression of conformationally unstable EGFP-fused firefly luciferase, which forms intracellular foci and exhibits reduced activity upon proteotoxic stress, elucidates the occurrence of proteostasis decline in mouse models of aging and tauopathy but not Huntington's disease.
Corrigendum
Free AccessComplete suppression of Htt fibrillization and disaggregation of Htt fibrils by a trimeric chaperone complex
EMBO J (2021) 40: e109413 | First Published: 04 October 2021
This article is a correction.
You are receiving this content alert because you are subscribed to
The EMBO Journal as
inn...@googlegroups.com.
If you no longer wish to receive these alerts you can
unsubscribe here.
You can manage all of your EMBO Press content alerts at https://www.embopress.org.
