Table of Contents Alert: The EMBO Journal, Vol. 39, No. 24, 15 December 2020
The EMBO Journal
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The EMBO Journal Volume 39, Issue 24 15 December 2020 |
On the cover: Elevator mechanism of a mammalian sodium/proton exchanger. In this issue of The EMBO Journal, Iven Winkelmann, Rei Matsuoka, Pascal F. Meier, David Drew and colleagues detail the structure of the horse sodium/proton exchanger NHE9 dimer embedded into a membrane bilayer using MD simulations. Image credit: Ricky Sexton.
News & Views
The last wall of defense to prevent extreme and deleterious mitochondrial fusion
Luis Carlos Tábara, Julien PrudentEMBO J (2020) 39: e107326 | First Published: 09 December 2020
A new study identifies mitochondrial safeguard mechanisms that compensate unbalanced mitochondrial dynamics and preserve respiratory functions in mammalian cells.
Rebellious autophagy proteins bypass ATG8 lipidation, taking their own path to autophagic degradation
Thanh Ngoc Nguyen, Michael LazarouEMBO J (2020) 39: e106990 | First Published: 23 November 2020
A new study characterises a pathway that drives autophagy‐dependent degradation of NBR1‐positive cargos in the absence of LC3/GABARAP lipidation.
Immune subversion by HIV: part B
Christophe Vanpouille, Leonid MargolisEMBO J (2020) 39: e107167 | First Published: 08 December 2020
HIV‐1 evades the immune system through multiple strategies involving direct killing of infected CD4 T cells and suppression of B cell maturation to prevent the production of neutralizing antibodies.
Articles
Open AccessStructure and elevator mechanism of the mammalian sodium/proton exchanger NHE9
Iven Winklemann, Rei Matsuoka, Pascal F Meier, Denis Shutin, Chenou Zhang, Laura Orellana, Ricky Sexton, Michael Landreh, Carol V Robinson, Oliver Beckstein, David DrewEMBO J (2020) 39: e105908 | First Published: 29 October 2020
Cryo‐EM structures reveal conserved architecture and exchange mechanism of the horse endosomal Na+/H+ exchanger NHE9.
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering‐induced Oma1 activation
Daisuke Murata, Tatsuya Yamada, Takeshi Tokuyama, Kenta Arai, Pedro M Quirós, Carlos López‐Otín, Miho Iijima, Hiromi SesakiEMBO J (2020) 39: e105074 | First Published: 17 November 2020
Short pulses of membrane depolarization drive a mitochondrial stress response, named mitochondrial safeguard, that maintains mitochondrial function in response to excessive organelle connectivity.
Open AccessReceptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy
Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J ShoemakerEMBO J (2020) 39: e104948 | First Published: 23 November 2020
TAX1BP1‐dependent clustering of the autophagy protein RB1CC1/FIP200 around its cargo promotes autophagosome formation and enforces selective cargo incorporation in the absence of core ATG factors and LC3 lipidation.
Open AccessHIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function
Sheetal Kaw, Swetha Ananth, Nikolaos Tsopoulidis, Katharina Morath, Bahar M Coban, Ralph Hohenberger, Olcay C Bulut, Florian Klein, Bettina Stolp, Oliver T FacklerEMBO J (2020) 39: e105594 | First Published: 04 November 2020
Prevention of polarized cytokine secretion at the immune synapse of infected helper T cells reduces B cell activation, providing a basis for impaired neutralizing antibody responses observed in HIV‐1 patients.
Free Access
HighlightBlood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage
Yan‐Mei Chen, Yuanting Zheng, Ying Yu, Yunzhi Wang, Qingxia Huang, Feng Qian, Lei Sun, Zhi‐Gang Song, Ziyin Chen, Jinwen Feng, Yanpeng An, Jingcheng Yang, Zhenqiang Su, Shanyue Sun, Fahui Dai, Qinsheng Chen, Qinwei Lu, Pengcheng Li, Yun Ling, Zhong Yang, Huiru Tang, Leming Shi, Li Jin, Edward C Holmes, Chen Ding, Tong‐Yu Zhu, Yong‐Zhen ZhangEMBO J (2020) 39: e105896 | First Published: 03 November 2020
Proteomics, metabolomics and RNAseq data map immune responses in COVID‐19 patients with different disease severity, revealing molecular makers associated with disease progression and alterations of tissue‐specific proteins.
Open AccessSARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
Theodora Myrto Perdikari, Anastasia C Murthy, Veronica H Ryan, Scott Watters, Mandar T Naik, Nicolas L FawziEMBO J (2020) 39: e106478 | First Published: 17 November 2020
The nucleocapsid protein from SARS‐CoV‐2 undergoes liquid‐liquid phase separation with RNA and can partition into droplets formed by TDP‐43, FUS or hnRNPA2.
Open AccessHighlightCryo‐EM structure of native human uromodulin, a zona pellucida module polymer
Alena Stsiapanava, Chenrui Xu, Martina Brunati, Sara Zamora‐Caballero, Céline Schaeffer, Marcel Bokhove, Ling Han, Hans Hebert, Marta Carroni, Shigeki Yasumasu, Luca Rampoldi, Bin Wu, Luca JovineEMBO J (2020) 39: e106807 | First Published: 16 November 2020
Insights into the architecture of uromodulin filaments involved in the capture of uropathogenic bacteria, and structurally‐related vertebrate egg coat material, suggest how a widespread extracellular polymerization module can support multiple functions.
Open AccessDistinct retrograde microtubule motor sets drive early and late endosome transport
Giulia Villari, Chiara Enrico Bena, Marco Del Giudice, Noemi Gioelli, Chiara Sandri, Chiara Camillo, Alessandra Fiorio Pla, Carla Bosia, Guido SeriniEMBO J (2020) 39: e103661 | First Published: 20 November 2020
Differential engagement of STIM1/dynein and the kinesin‐14 KIF1C motor protein complexes regulates distinct subcellular distribution of early and late endosomes.
HighlightSite‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling
Lilian M Fennell, Carlos Gomez Diaz, Luiza Deszcz, Anoop Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkruys, Josef Penninger, Fumiyo IkedaEMBO J (2020) 39: e103303 | First Published: 20 November 2020
Ubiquitination of the catalytic subunit of the linear ubiquitin chain assembly complex LUBAC is required for full induction of the NF‐κB pathway and TNF‐induced inflammatory signalling in mice.
Open AccessAn alternative miRISC targets a cancer‐associated coding sequence mutation in FOXL2
Eunkyoung Shin, Hanyong Jin, Dae‐Shik Suh, Yongyang Luo, Hye‐Jeong Ha, Tae Heon Kim, Yoonsoo Hahn, Seogang Hyun, Kangseok Lee, Jeehyeon BaeEMBO J (2020) 39: e104719 | First Published: 20 November 2020
A cancer mutation introduces a novel miR‐1236 target site in FOXL2 mRNA, causing its miRNA‐mediated decay and leading to FOXL2 tumor suppressor haploinsufficiency.
HighlightBCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage
Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas StrasserEMBO J (2020) 39: e105561 | First Published: 25 November 2020
Genetic loss of anti‐apoptotic BCL‐XL causes fatal kidney damage and secondary anemia in adult mice subjected to total body irradiation.
Open AccessInteractions between lineage‐associated transcription factors govern haematopoietic progenitor states
Iwo Kucinski, Nicola K Wilson, Rebecca Hannah, Sarah J Kinston, Pierre Cauchy, Aurelie Lenaerts, Rudolf Grosschedl, Berthold GöttgensEMBO J (2020) 39: e104983 | First Published: 26 October 2020
Functional definition of a transcription factor network reveals regulatory interdependencies during early blood development.
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