As an in-house art director for a large commercial printer for the 1980s, I can say that your real problem is going to be your printer. You are talking about images on different sides of a huge sheet of paper, and maybe even two different sheets of paper. That is incredibly difficult to get lined up.
The only thing we found that worked was to have two copies of the image and put them in the two locations. Other than the center spread (and where is that in a perfect bound book) you are always going to have printing problems. In a perfect bound book both of the images must bleed off the spine side, and be trimmed out.
We solved it by tripling our printing costs for those spreads. That usually solved our problem. We could still make a little money if we had to print it—not much. But mainly the designers backed off at the price. We were the best in town, so they had no where else to go.
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David Bergsland
Bergsland Design & Hackberry Font Foundry [now a peripheral part of The Skilled Workman]