Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France.
Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. A member of the American Society for Biochemistry and Molecular Biology, Grisham held the Knapp Chair in Chemistry in 1999 at the University of San Diego; was Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark, for two years; and received a Research Career Development Award from the National Institutes of Health.
Careers in Chemistry features showcase various career paths readers can take after studying biochemistry. Featuring a diverse, inclusive and equitable chemical community, these examples help inspire all readers to see a future for themselves in chemistry-related careers.
A number of new and updated Deeper Look and Critical Developments in Biochemistry features expand on key topics or experimental observations while addressing the latest developments in biochemistry, such as human preteome, NMR, Cryo-EM, AlfaFold and CRISPR-Ca-9.
A new, semester-long Protein Structure and Function Exploration Project invites readers to study a protein and use protein-modeling software to learn biochemistry actively in an in-depth research and writing project.
Human Biochemistry essays emphasize the central role of basic biochemistry in medicine and the health sciences. These essays often present clinically important issues such as diet, diabetes and cardiovascular health.
This biochemistry textbook is designed to communicate the fundamental principles upon which all life is based to students encountering biochemistry for the first time. We aim to bring an appreciation of biochemistry to a broad audience that includes undergraduates majoring in the life sciences, physical sciences, or premedical programs as well as medical students and graduate students in the various health sciences for whom biochemistry is an important route to understanding human physiology.