Recently I've been frustrated by ROI's being limited to 2D. With the
emerging utility of the 3D viewer and the proposal that ImageJ 2.0
handles N-dimensional data, it makes sense that ROIs should keep up
with this development.
In other words, in an N-dimensional image, one should be able to
specify and visualise an N-dimensional ROI. So you can have a 3D VOI,
and a 4D VOI with time limits (or even changing shape over time), or
limit the ROI to a channel (5D).
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