Hi Francesco,
I have to amend my answer a bit. It looks like this issue only arises when VPAID mode is set to ENABLED, or not set at all. Everything works fine with VPAID mode set to INSECURE. I realize now that my Advanced Example based test page was INSECURE, while the Simple Example test page did not have a VPAID mode set. Our team also determined that when the issue does arise, the ad is still rendering it's click elements, it's just rendering them with size 0x0. This is an issue with the ad itself, which you'll have to resolve with your creative provider.
To get this working right now, you have a two options. You can either use INSECURE mode for VPAID, or if that isn't an option, you can use ENABLED mode if you keep init and start together. Is there a reason you have to have the two calls separate? You could delay both and then call them back to back at a later time.
Let me know if you continue to have issues.