Pro Poster 2.02.15.serial Key.ra
Randell Magtoto
Authored by leading experts in the field, and summarizing key areas of research, the following range of life science posters provide a colorful and informative source of information. We invite you to request* or download your copy today.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Multiple sclerosis (MS) is an autoimmune disease that is characterized by focal demyelination and axon degeneration in the central nervous system. This poster summarizes the neurobiology and current therapies of MS.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Biology undergraduates and Masters students are invited to present a poster based on research they are conducting while at UC San Diego. At the showcase, students are expected to present their research to attendees and faculty judges. Top posters receive awards at the conclusion of the event.
It is a great opportunity to make connections with faculty, practice communicating science to the public, and network with fellow students. The showcase is open to the public. Faculty, staff, students, and even industry representatives come to check out the research our students are conducting.
Top posters in each category (or combined category) will win a gift card award. Awards are presented to students after poster judging. Student posters are scored based on content (innovation, creativity, quality and originality) and communication (how well did the poster present the central theme and results of research, student communicates concisely and clearly, poster covers key points of research and includes important data, student answered questions effectively).
Rheumatoid arthritis involves a disease process (like cancer or diabetes) where the body's immune system mistakenly attacks its own healthy joints. It is a relatively common disease-approximately 1 in 100 people get it-and is often devastating to a person's body if not treated properly. Within ten years of the onset of the disease, up to 50% of people living with RA are work disabled if untreated. For those living with RA, related inflammation in the arteries result in an increased risk of mortality. When moderate to severe, the disease reduces a person's life span by as much as a dozen years. Today, effective RA treatments exist, which can change these outcomes.
If you are a loved one, friend, co-worker of a person with RA, you likely have been struck by a range of traits and characteristics that reflect their resilience and adaptation to the disease. People living with RA are some of the most resilient, perseverant, patient, and compassionate people you will ever meet.
Those qualities are reflected by the member organizations of the GRAN who together, through collaboration, develop, test, and deliver solutions to address the unmet needs of RA patients in Europe and the Americas.
This holiday season, the Global RA Network is looking back at another year of significant achievements that had a positive impact on RA patient lives. We are also looking ahead to work in 2024 that will help advance RA treatment and care in Global RA Network member countries in Europe and the Americas.
Looking ahead to 2024, the Global RA Network is focussing on learning about the lived experiences of RA patients accessing care in Europe and the Americas. This work will significantly contribute to a better understanding of current RA care models and the identification of emerging public policy priorities. The GRAN will share this valuable data with healthcare providers and policymakers to help improve RA care models, arthritis health policies, and overall patient outcomes.
To all our brothers and sisters living with RA around the world, we wish you a safe and healthy holiday season. We hope you will come back to visit us in the coming months and learn more about how you can help support our activities to dramatically change the lives of people living with RA in your country.
Our Secretariat delegates from ACE attended the ACR Convergence meeting in San Diego, California from November 10 to 15, 2023. They have returned with valuable insights and the latest advancements in rheumatoid arthritis (RA) research. The annual scientific gathering, hosted by the American College of Rheumatology, offered hundreds of sessions about the latest research, advancements, and breakthroughs in arthritis to educate arthritis patients and professionals in every segment of rheumatology including clinicians, researchers, academicians, practice managers, pediatric rheumatologists, fellows in training, advance practice nurses, physician assistants, physical or occupational therapists from around the world. The meeting provided participants with access to in-person sessions, as well as on-demand recordings of each lecture and the 10-minute Q&A that followed most lectures, which were available to those joining remotely.
At a special session called the ACR Global Summit, Dr. Jayasree K. Iyer, CEO of the Access to Medicine Foundation, highlighted that despite advancements in drug development, nearly 2 billion people lack regular access to essential medicines, impacting health and increasing mortality. The focus on medicine access tends to prioritize diseases causing death, leaving chronic diseases like inflammatory arthritis, neglected.
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