癌症 - 教授莊祖儀談皮膚癌的預防和治療

[Howard Peng]

On Thursday, October 8, 2015 at 12:30:00 PM UTC-7, Wuhow Peng wrote:

  
   https://zh.wikipedia.org/zh-tw/%E7%99%8C
   癌（Carcinoma），有翻譯為惡性上皮細胞腫瘤，是癌症的一種。在醫學上專指
   由上皮組織來源的惡性腫瘤，其它由結締組織來源的惡性腫瘤只稱作惡性腫瘤，
   如：肌肉或骨骼的惡性肉瘤（Sarcoma）、黑色素細胞的惡性黑色素瘤（Melanoma）、
   生殖細胞的畸胎瘤（Teratoma），而血液科的惡性腫瘤則使用白血病及淋巴瘤的名稱。
   隨著病毒學的發展，至今已發現有百分之20左右的癌症為病毒所引起的。

   由於絕大多數惡性腫瘤病例是惡性上皮腫瘤，因此在一般用途上癌已成為惡性腫瘤的
   同義詞，其它種類的惡性腫瘤也常被稱為癌或癌症，例如白血病就被稱為血癌。

   在全球範圍內，各類癌症是人類第三大的死因，僅次於心血管疾病和各類感染和
   寄生蟲類疾病；在臺灣，自1982年起，癌症就一直是臺灣人第一大的死因。

  https://en.wikipedia.org/wiki/Carcinoma
 
    http://www.newhopecancer.org/
    
    莊醫師講座內容講義資料請按此連結：Skin Cancer- Many Faces

    五月是皮膚癌防治月，我們十分榮幸，邀請到南加州知名的皮膚科醫師
    也是教授莊祖儀談皮膚癌的預防和治療，座無虛席。

    皮膚癌的“大三元”是基底細胞癌，鱗狀細胞癌，及人人談虎色變的黑素瘤。
   卡特總統正是黑素瘤的受害者。美國平均一年有三百五十萬皮膚癌患者。
   莊醫師也回答了許多的問題，包括痣的觀察，在接受治療時的皮膚變化等等，

   莊祖儀醫師是加州洛杉磯縣北嶺市(Northridge), 合夥醫療網(Healthcare Partners)
   皮膚科醫師。他也是南加大(USC) 皮膚科臨床教授。莊醫師曾任台大及芝加哥大學
   皮膚科總醫師,擔任過三所大學的教授(威斯康新大學,俄州萊特大學及印地安那大學),
   二所大學的臨床教授(南佛大及南加大)。在印地安那大學期間(1995-2004),
    任羅倫思講座教授及黑素瘤癌症中心主任。他的專長是皮膚癌及皮膚病流行病學。
    http://www.newhopecancer.org/wp-conten/uploads/Skin-Cancer-Many-Faces.ppt
    Dear All, 諸位同學們，
 
  
　　看一看此電話訪問，easy to understand.
    Tomas Lindahl of the Francis Crick Institute
    Francis Crick (Francis Harry Compton Crick) was born on June 8th,
    1916, at Northampton, England, being the elder child of Harry Crick
    and Annie Elizabeth Wilkins. A co-discoverer of the structure of
    the DNA molecule in 1953 with James Watson.　
　  四十年前，我就對 DNA 感到興趣，真的嗎？真的！
　　誰要去學，沒有人要去學，不好玩！
　　誰要來去美國(台灣)玩？　哈！哈！哈！

 
  ------ Tomas Lindahl的電話談話　-----

　   "I feel very lucky and privileged"

    Telephone interview with Tomas Lindahl following the announcement 
    of the 2015 Nobel Prize in Chemistry, 7 October 2015.
    The interviewer is Adam Smith, Chief Scientific Officer of Nobel Media.

    [Tomas Lindahl] Tomas here.

    [Adam Smith] Oh hello, my names Adam Smith, calling from
         Nobelprize.org, the official website of the Nobel Prize
         in Stockholm.

    [TL] Hello.

    [AS] Hello. Many congratulations on the award of the Nobel Prize.

    [TL] Thanks very much. 

    [AS] Could you tell me, how did you hear the news?

    [TL] I had a phone call early this morning, just a couple of
         hours ago I guess, or an hour ago, from the Swedish Academy
         telling me this very good news.

    [AS] An amazing phone call to get. What was your first reaction?

    [TL] Well, surprise to some extent, not 100% surprise because
         Im getting up in the years and I know that I have been 
         one of the well known scientists in my field of science,
         which is DNA repair for many years. So the question was
         will there be a Prize for DNA repair, and I think many
         people have now realised its a very important topic of
         research, and if so there would be 10, 15 excellent 
         people you could choose from, and you cant give the Nobel Prize
         to more than three people. So I feel very lucky and
         privileged to be included in the top class that was awarded.

    [AS] And it must be very special because I think youre
         the first Swede to receive the Chemistry Prize for 67 years,
         since Tiselius ...

    [TL] That may well be, yes.

    [AS] Does that make it more special?

    [TL] Yes, I think so because I got my initial training in Sweden,
         and I also had the difficult decision to do there, in that
         I was studying medicine, and research started looking very
         interesting and intriguing, so should I put aside my clinical
         studies for some time and concentrate on the research instead.
         And thats a risky decision to make for a young fellow, 
         but I took the chance and I think it has worked out. 

    [AS] It has paid off, yes. As you say the Prize is for
         the field of DNA repair and youre considered a father
         figure in the field, and youve devoted your life also 
         to cancer research for some decades, and ...

    [Phone beeps]

    [TL] Pardon.

    [Phone beeps]

    [TL] Im not a politician, Im not used to talking on two phones
         at the same time, sorry ...

    [AS] I was just saying youve devoted your career to cancer
         research for some decades also, and these DNA repair mechanisms,
         they help protect our DNA but they also in some ways help
         protect cancer cells dont they?

    [TL] Yes, thats an important topic of modern research. We want to
         understand repair mechanisms in some detail so that we can
         prevent the cancer cells from repairing DNA when we, for example,
         expose them to radiotherapy. But we do need the repairs to
         protect us against DNA damage that occurs inevitably.

    [AS] Lastly, would you say the prospects for cancer research,
         for treating cancer or at least for turning cancer into
         a chronic disease, are good at the moment?

     [TL] Yes, that is a very good and hot topic, not only for
          cancer but I think for many diseases. In this case 
          we are getting away a little bit of trying to find
          a cure for everything and convert diseases into 
          something we can live with. The reason weve had for
          a long time with diabetes. Its difficult to cure diabetes 
          but we have good ways of treating diabetic patients. 
          And I think with regard to DNA damage that will be 
          increasingly important aspect of it. Im home now because 
          I was going to do some writing at home today, but after 
          this message it was decided that a driver will 
          take me out to the laboratory where the work has been done
          in North London.

    [AS] Yes

    [TL] Thats the Clare Hall Laboratories.

    [AS] Are you enjoying this? This attention?

    [TL] Of course. Its always nice at the end of your career 
         to have recognition that what you have done is actually
         important.

    [AS] Indeed, indeed. Well how lovely to speak to you,  
         thank you. I look forward to seeing you again in Stockholm
         in December and hopefully sooner in London.

    [TL] OK.

    [AS] Thank you. Bye bye, congratulations.

   敬祝天天開開心心的玩！


 Best Regards,
 物理科學小學生
　wu how On Thursday, October 8, 2015 at 8:09:49 AM UTC-7 ,Wuhow Peng wrote:

    何兄 Wayne, and Dear All, 諸位同學們，

　　
　　謝謝，我愛讀很艱深(hard to understand) 科學(我是小學生程度)的文章，
　　對一般的文獻則不見得會注重。

　　　我有許多親戚和患癌症，經過痛苦的治療過程，治癒多年，
　　我對癌症知道的東西太少太少了，不妨害我愛讀很艱深科學的文章，
　　我會看一看的
     2.4.1  Endogenous causes
       2.4.1.1  Inherited germ line mutations
          As  mentioned, only a minority (5–10 per cent) of cancers are
          linked to single inherited genes.
　     
        2.4.1.2
        Oxidative stress
         Reactive oxygen species generated through normal oxidative
         metabolism have the potential to cause extensive DNA dam-
         age. The body has several mechanisms, which can scavenge
         reactive oxygen species to prevent such damage occurring,
         or block the effects.
   2.4.2 Exogenous causes
　　句
　　讀ㄉㄡˋ　　
　　　
　　　
　　這是我主動發這個
   Subject: 今年 2015 諾貝爾獎化學的得獎人三位：Tomas Lindahl, Paul Modrich and
           Aziz Sancar 與他們的貢獻　　

　　希望我們大家對今年諾貝爾獎化學的三位得獎人的研究成果與癌症治癒的
   概念(concept)有所知悉，是我寫　email 的主要意思也。

 　今年六月住在台灣，參與三位近親晚輩的喜事，真高興，最高興的事情是
　　一位妹妹說將要來美國玩！

　今天下午，到老人中心，唱歌跳舞，老人家(該像小孩子一樣)，好好去玩！　　

　
  
　敬祝天天開開心心的玩！

 Best Regards, 物理科學小學生
　wu how　

 　　　　　
   On Wednesday, October 7, 2015 at 9:53:55 PM UTC-7, wayne ho wrote:

    Dear WH,

    because of your long time as a volunteer for cancer patients, I believe you will be interested in the following latest reference book. Food, Nutrition, Physical activity and the Prevention of Cancer: a Global Perspective (2007 edition)
    http://www.wcrf.org/int/research-we-fund/continuous-update-project-cup/second-expert-report

    Down load is free, in chapter 2 :cancer process: you will find at least 3 DNA repair mechanisms, 3 scientists share the 2015 Nobel prize for their respective discoveries.
     
    wayne


    On Wed, Oct 7, 2015 at 7:18 AM, 'Wuhow' via CD1968 <cd1...@googlegroups.com> wrote:

    Dear All, 諸位同學們，

 
   



　　　　2015 CHEMISTRY QUESTION
　　　　Did you know that your DNA is constantly in need of repair?
　　　　77%　　　22%
　　　　Yes　　　No
   

        CTUAA › 科學報導
　   　 http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2015/press.html

　　　　今年諾貝爾獎化學的得獎人三位：Tomas Lindahl, Paul Modrich and
       Aziz Sancar
　　　　他們的貢獻　　：　
　
　　　　↓
       The cells’ toolbox for DNA repair

　　　The Nobel Prize in Chemistry 2015 is awarded to Tomas Lindahl,
　　　Paul Modrich and Aziz Sancar for having mapped, at a molecular level,
　　　how cells repair damaged DNA and safeguard the genetic information.
      Their work has provided fundamental knowledge of how a living 
      cell functions and is, for instance, used for the development of
      new cancer treatments.
      Each day our DNA is damaged by UV radiation, free radicals and other
      carcinogenic substances, but even without such external attacks,
      a DNA molecule is inherently unstable. Thousands of spontaneous

       changes to a cell’s genome occur on a daily basis. Furthermore,

       defects can also arise when DNA is copied during cell division,

       a process that occurs several million times every day in the human body.　　　　　　　

 　-------
  飲水思源
  --------
   You received this message because you are subscribed to the Google Groups "CD1968" group. 

   To post to this group, send email to cd1...@googlegroups.com.
   Visit this group at http://groups.goo...com/group/cd1968